LABORATORY CHEMICAL INFORMATION SUMMARY: TRIMETHYLTIN CHLORIDE

(AND OTHER ORGANOTIN COMPOUNDS)

Substance

Trimethyltin chloride

(chlorotrimethylstannane)

CAS 1066-45-1

Other organotin compounds: tributyltin chloride, tributyltin hydride

 

Formula

C3H9ClSn

 

Physical Properties

White crystalline solid

mp 37 to 39 °C

Insoluble in water

 

Odor

Strong unpleasant stench; no threshold data available

Flash Point

97 °C

 

Toxicity Data

LD50 oral (rat)

12.6 mg/kg

 

PEL (OSHA)

0.1 mg tin/m3

 

The ACGIH has established the following uniform exposure limits for all organotin compounds based on the concentration of tin in air:

 

TLV-TWA (ACGIH)

0.1 mg tin/m3

 

STEL (ACGIH)

0.2 mg tin/m3

Major Hazards

Trimethyltin chloride is highly toxic by all routes of exposure.

Toxicity

Trimethyltin chloride and other organotin compounds are highly toxic by ingestion, inhalation, or skin contact. Trimethyltin chloride can cause irritation and burns of the skin and eyes. Organotin compounds can affect the central nervous system. The degree of toxicity is greatest for compounds with three or four alkyl groups attached to tin. Diand monoalkyltin compounds are moderately toxic. The toxicity diminishes as the size of the alkyl groups increases. Thus, the oral LD50s in rats are as follows: dimethyltin dichloride, 74 to 237 mg/kg; tributyltin chloride, 122 to 349 mg/kg; dibutyltin oxide, 487 to 520 mg/kg; trioctyltin chloride, >4000 mg/kg.

Organotin compounds have been shown to cause reproductive effects in laboratory animals.

Flammability and Explosibility

Not a significant fire hazard. Emits toxic fumes in fire.

Reactivity and Incompatibility

Trimethyltin chloride and other organotin halides react with water to produce hydrogen halides. Organotin hydrides react with water to produce hydrogen gas, which is flammable and explosive.



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