91. Roberts, G. C. K. (1993) NMR of Macromolecules (Oxford Univ. Press, New York).

92. Cohen, F. E. & Moos, W., eds. (1993) Perspect. Drug Discovery Des. 1, 391-417.

93. Olson, G. L., Bolin, D. R., Bonner, M. P., Bos, M., Cook, C. M., Fry, D. C., Braves, B. J., Hatada, M., Hill, D. E., Kahn, M., Madison, V. S., Rusiecki, V. K., Sarabu, R., Sepinwall, J., Vincent, G. P. & Voss, M. E. (1993) J. Med. Chem. 36, 3039-3049.

94. Smith, A. B., Hirschmann, R., Pasternak, A., Akaishi, R., Guzman, M. C., Jones, D. R., Keenan, T. P., Sprengeler, P. A., Darke, P. L., Emini, A., Holloway, M. K. & Schleif, W. A. (1994) J. Med. Chem. 37, 215-218.

95. Hirschmann, R., Sprengeler, P.A., Kawasaki, T., Leahy, J. W., Shakespeare, W. C. & Smith, A. B., III (1992) J. Am. Chem. Soc. 114 , 9699-9701.

96. Bunin, B. A., Plunkett, M. J. & Ellman, J. A. (1994) Proc. Natl. Acad. Sci. USA 91, 4708-4712.

97. Zahner, H., Anke, H. & Anke, T. (1983) in Secondary Metabolism and Differentiation in Fungi, eds. Bennett, J. W. & Ciegler, A. (Dekker, New York), pp. 153-171.

98. Doolittle, R. & Bork, P. (1993) Sci. Am. 269, 50-56.

99. Caporale, L. H. (1973) Ph.D. Thesis (Univ. of California, Berkeley).

100. Hozumi, N. & Tonegawa, S. (1976) Proc. Natl. Acad. Sci. USA 73, 3628-3632.

101. Rossman, M. G. (1981) Philos. Trans. R. Soc. London B. 293, 191-203.

102. Gilbert, W. (1978) Nature (London) 271, 501.

103. Sudhof, T. C., Goldstein, J. L., Brown, M. S. & Russell, D. W. (1985) Science 228, 815-822.

104. Patthy, L. (1993) Methods Enzymol. 222, 10-28.

105. Irwin, D. M., Robertson, K. A. & MacGillivray, R. T. A. (1988) J. Mol. Biol. 200, 31-45.

106. Hays, S. P. (1957) The Response to Industrialism 1885-1914 (Univ. of Chicago Press, Chicago).

107. Caporale, L. H. (1984) Mol. Cell. Biochem. 64, 5-13.

108. Graham, L. D., Haggett, K. D., Jennings, P. A., De Brocque, D. S. & Whittaker, R. G. (1993) Biochemistry 32, 6250-6258.

109. Kunkel, T. A. (1992) J. Biol. Chem. 267, 18521.

110. Woodward, S. R., Cruz, L. J., Olivera, B. M. & Hillyard, D. R. (1990) EMBOJ.9, 1015-1020.

111. Myers, R. A., Cruz, L. J., Rivier, J. E. & Olivera, B. M. (1993) Chem. Rev. 93, 1923-1930.

112. Pease, L. R., Schulze, D. H., Pfaffenbach, G. M. & Nathenson, S. G. (1983) Proc. Natl. Acad. Sci. LISA 80, 242-246.

113. Pech, M., Höchtl, J., Schnell, H. & Zachau, H. (1981) Nature (London) 291, 668-670.

114. Gordon, E. M., Barrett, R. W., Dower, W. J., Fodor, S. P. A. & Gallop, M. A. (1994) J. Med. Chem. 37, 1385-1401.

115. Merrifield, B., (1986) Science 232, 341-347.

116. Eiseley, L., (1959) The Immense Journey (Vintage, New York).

117. Linden, E. (1991) Time 9/3/91, 46-55.



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