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Index A AAAAI. See American Academy of Allergy, Asthma, and Immunology Abscesses, 34 Access control barriers, 108-109, 126 Accidents, 15, 25 Accountability and responsibility, 4, 15-17 Acoustical hazards. See Hazards, physical Administration and management, 2, 4, 8, 16-18, 22, 121. See also Commitment, element of consistency in, 4, 13, 15, 124 procedures, 6, 107 style and structure of, 23 Adverse-reaction report data, 27, 29 Aerosol transmission, 45, 48-49, 55-56, 73, 76, 85 African green monkeys, 46, 70, 78 Agricultural Research Service (ARS), 26 AIDS. See Susceptibility of employees Airborne exposures. See Aerosol transmission Air hoods. See Respirators Airway hyperresponsiveness. See Asthma Allergens. See Hazards Allergic conjunctivitis, 53 147 Allergic rhinitis, 53-54, 59-60 Amebiasis, 98-99 American Academy of Allergy, Asthma, and Immunology (AAAAI), 64 American National Standards Institute (ANSI), 117 Amphibians, 60 Anaphylaxis, 52-53, 64 Anesthetic gases, 42-43 Animal and Plant Health Inspection Service (APHIS), 26 Animal biosafety levels, 45, 81 Level 2 practices, 49, 72, 77, 80, 88, 90, 92, 94, 100-101 Level 3 practices, 49, 68, 73, 83, 86, 91 Level 4 practices, 48, 70 Animal care and use programs, 4, 18-20, 22, 112. See also Site inspections addressing occupational health in, 8 progress in, 1 Animal-control measures, 79 Animals. See also individual species species-specific responses to, 12, 107 wild, 13, 66-67, 79-81, 101-102 (~See also Rodents, wild)

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148 ANSI. See American National Standards Institute (ANSI) APHIS. See Animal and Plant Health Inspection Service (APHIS) Approvals required, 21, 39, 48 Arboviral infections, 45-46, 80-81 ARS. See Agricultural Research Service Arthritis, septic, 34 Arthropod-borne viruses. See Arboviral infections Arthropod infestations, 101 - 102, 104- 105 Asthma, 51, 53-54, 57-63 Atopy, 54 Authorizations required. See Approvals required B Back injuries, 40 Bacterial pathogens, 46-47, 85-95 Balantidiasis, 99 Benign epidermal monkeypod, 73-74 Biological hazards. See Hazards Biological safety cabinets, 109- 111, 117 Biosafety in Microbiological and Biomedical Laboratories, 45, 48, 125 Biosafety in the Laboratory: Prudent Practices for the Handling and Disposal of Infectious Materials, 48 Biosafety levels. See Animal biosafety levels Birds, 46, 59, 81-82, 85, 87-88, 93, 104 Bites and scratches. See Hazards, physical Bloodborne pathogens. See Hazards, biological Breathing, difficulty in, 53 Brucellosis, 34, 46, 90-91 Bubonic plague, 89-90 Bursitis, 40 B-virus infection, 27, 34, 46, 66-68 C Cage cleaning. See Housekeeping practices INDEX Cages, 62, 109-110 Campylobacteriosis, 46, 92 Cardiopulmonary resuscitation, 64 Carpal-tunnel syndrome, 40 Cats, 57-58, 71, 79, 81, 83-85, 95-97, 99 100, 102-104 Cat-scratch fever, 34, 83-84 Cattle, 46, 58-59, 85, 91 Cellulitis, 34 Centers for Disease Control and Prevention (CDC), 5, 25, 45, 66, 68, 72 Cercopithecine herpesvirus 1 (CHV1~. See B-virus infection Chemical fume hoods. See Respirators Chemical inventory data, 25 Chemical restraint, 15, 33, 35, 68 Chemicals, hazardous. See Hazards, chemical Chemoprophylaxis, 86, 88 Chlamydiosis. See Psittacosis Choriomeningitis, lymphocytic. See Lymphocytic choriomeningitis CHV1. See B-virus infection Cleaning hazards. See Housekeeping practices Collaboration. See Coordination within programs Commitment, element of, 4, 8, 13, 15, 23 24, 121 Compliance Database data, 29-30 Compliance issues, 17, 23, 107. See also Approvals required; Regulatory requirements Compressed-gas cylinders, 36 Computer links, 120 Confidentiality, 118 Conjunctivitis, allergic, 53 Consultants, using, 30-31, 64, 129, 132 Contagious ecthyma, 34, 74-75 Coordination within programs, 2-5, 8, 13, 15, 18,21,65 Coxiella burnetii. See Q fever Coyotes, 46 Credibility issues, 15 Cryptosporidiosis, 97-98

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INDEX Custodial service. See Housekeeping practices Cylinders, compressed-gas, 36 D Deer, 59 Dermatitis atopic, 54 contact, 59 contagious pustular (See Orf disease) Dermatomycosis, 47, 99- 100 Disinfectants, 42-43 Documentation, 118 Dogs, 46-47, 58, 79, 81, 84-85, 90-91, 95, 97, 99-100, 102-105 Dust-mist respirators. See Respirators E Ebola-Reston virus, 69 Ebola-virus infection, 68-70 Ecthyma, contagious. See Orf disease Ectoparasitic infestations, 34, 74-75 Eczema. See Dermatitis, atopic Edema, laryngeal, 53 Education and training, 4, 6, 12-14, 17, 34, 39-40, 62-63, 65, 114-116 Electric hazards. See Hazards, physical Electromagnetic radiation. See Ionizing radiation ELISA. See Enzyme-linked immunosorbent assay Emergency procedures, 6, 120-121. See also Accidents Employees defined (See Occupational health and safety programs, participation in) et risk, 4, 12, 17, 22, 111, 120, 129- 130 (See also Hazards, perceived; Screening programs; Susceptibility of employees) Endocarditis, 34 Engineering controls, 108- 110 Enteric yersiniosis, 95 149 Envenomation, 34 Environmental health and safety programs, 2, 4, 6-7, 9, 18, 21-22, 29, 106 Environmental Protection Agency, 2 Enzyme-linked immunosorbent assay (ELISA), 61 Epinephrine, self-administered, 64 Episodic health evaluations, 10, 29, 131 Equipment, dangerous, 40-41 Equipment performance, 6, 25, 116-118 Ergonomic hazards, 40, 108. See also Hazards, physical Evaluation program, 6, 121-122, 133-134 of workers, 63-64, 124, 130-131, 133 (See also Episodic health evaluations) Experimentation. See Research Exposure, 4, 13-14, 43, 55, 125, 127 controlling, 4, 25, 108-114 F Facilities, 17, 107-108 design, 6, 62 operation, 6 Federal Bureau of Labor Statistics data, 27-28 Ferrets, 80, 85 Filoviruses. See Ebola-Reston Filter-top cages, 62, 109-110 Fires. See Hazards, physical First-aid log data, 27, 29, 134 First Report of Injury or Illness data, 27- 28 Fish, 60 Flammable materials, classes of, 35 Flea-control measures, 84 Fleas. See Insects Flight zone, 33 Fowl. See Birds Fume hoods. See Respirators Funding agencies, requirements of, 2 Fungal pathogens, 34, 47, 99- 101

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150 G Gene therapy research, 48. See also Guidelines for Research Involving Recombinant DNA Molecules Gerbils, 56 Giardiasis, 97 Goats, 46-47, 74-75, 85 Guide for the Care and Use of Laboratory Animals, 63 Guidelines. See Rules and guidelines Guidelines for Research Involving Recombinant DNA Molecules, 48, 124 Guinea pigs, 46-47, 56, 95, 104 H Hamsters, 46, 102 Hantavirus infection, 34, 71-72 Hazard Communication Standard, 42 Hazard information, sources of, 25-26 Hazards. See also Laboratory safety allergens, 3, 5-6, 24, 26, 51-64 (See also Evaluation, of workers) mechanisms of, 53-54 preventive measures, 60-64 biological, 7, 127 (See also Approvals required) infectious agents, 2, 7, 12-13, 44-48, 124 radiation sources, 12, 20-21, 36-39 chemical, 2, 5, 12-14, 24, 42-44 defined, 26 identifying (See Risk Assessment) novel, 47 perceived, 24 physical, 3, 5, 7, 24, 26, 32-41, 127 (See also Housekeeping practices) bites and scratches, 33-34, 44, 52-53 electricity, 36 fires, 35, 118 noise, 41 trauma, 40 protocol-related (See Research, protocol-related hazards of) INDEX undetected, 14, 31 unknown, 44, 66 zoonoses, 3, 6, 14, 20, 44-45, 65-105 HBV. See Hepatitis-B virus (HBV) Health and safety risks. See Hazards Health Research Extension Act of 1986, 124 Helminth-parasite infections, 101-103 Hemorrhagic fever. See Hantavirus infection; Lymphocytic choriomeningitis (LCM) virus infection HEPA filtration. See High-efficiency- particulate-air-filtered (HEPA- filtered) laminar-flow ventilation Hepatitis A virus, 46, 76-77 Hepatitis B virus (HBV), 7, 77-78, 124 Hepatitis C, D, and E viruses, 77-78 High efficiency-particulate-air-filtered (HEPA-filtered) laminar-flow ventilation, 62, 110- 112, 117 High-pressure lines, 36 Hives. See Anaphylaxis; Edema, laryngeal; Uticaria, contact Hoods. See Respirators Horses, 59 Housekeeping practices, 39, 110, 112-113 Human-influenza viruses, 80 Human-resources function, 22 Husbandry, animal. See Animal care and use programs Hygiene, personal, 48-50, 63, 65, 111 - 112 Hypersensitivity, 54, 59 I IACUC. See Institutional animal care and use committee ILAR. See Institute of Laboratory Animal Resources Immunizations. See Vaccinations Immunotherapy, 64 Influenza-virus infections, 80 Information management, 6, 118- 120. See also Occupational health and safety information, sources of

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INDEX Insects, 58, 60, 83-84 Inspections. See Site inspections Institute of Laboratory Animal Resources, 25 Institutional animal care and use committee (IACUC), 2, 5, 18-21, 107, 121 Institutions categories of, 1-2 functional parts of, 4, 16-22 mission, 4, 123 obligations of, 1, 16, 124 Interactions between departments, 18-19, 130, 134. See also Coordination within programs Ionizing radiation, 38-39. See also Hazards, biological IPAC. See Public Health Service Advisory Committee on Immunization Practices Irradiation. See Ionizing radiation J Janitorial service. See Housekeeping practices Job descriptions, 12, 22 L Laboratory safety, 2, 42, 65, 85, 110-114 Laboratory Safety: Principles and Practices, 48 Laboratory standard. See Occupational Exposure to Hazardous Chemicals in Laboratories Laryngeal edema, 53 Laser radiation, 37-38. See also Hazards, biological Lassa fever, 72 LCM. See Lymphocytic choriomeningitis (LCM) virus infection Lentivirus infections. See Simian immunodeficiency virus (SIV) infection Leptospirosis, 47, 91-92 151 Lifting injuries, 40 Lighting, low, 36 Livestock, 46, 99. See also individual species Lymphocytic choriomeningitis (LCM) virus infection, 14, 46, 65, 72-73 M Macaques, 46, 69, 74, 78, 85, 125 Machinery, dangerous, 40-41 Management. See Administration and management Marburg-virus disease, 46, 70 Material-Safety Data Sheets (MSDSs), 25, 35, 127 Measles, 75-76 Medical-surveillance programs, 78, 124, 134 Meningitis, 34 Mice, 46-47, 55-56, 91, 102, 104 Monitoring, 4, 13, 15, 22, 61, 116. See also Recordkeeping of effluent, 118 Monkeypox, 73-74 Monkeys, various, 76-78. See also African green monkeys; Macaques Morbidity and Mortality Weekly Report, 66 MSDSs. See Material-Safety Data Sheets Multidisciplinary approaches, 9 N National Animal Disease Center (NADC), 26 National Center for Infectious Diseases, 72-73 National Fire Protection Association (NFPA), 35 National Institute for Occupational Safety and Health (NIOSH), 25, 40, 63 National Institutes of Health (NIH), 5, 26, 45, 68, 124-125 National Research Council, 1, 5 recommendations by, 8-10

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152 National Safety Council (NSC), 38 National Sanitation Foundation (NSF), 117 Near-miss reports, 131 - 132 Neuropathia endemica. See Hantavirus infection Newcastle disease, 76 NFPA. See National Fire Protection Association NIH. See National Institutes of Health NIOSH. See National Institute for Occupational Safety and Health Noise. See Hazards, physical Nonparticulate radiation. See Ionizing radiation NSC. See National Safety Council NSF. See National Sanitation Foundation o Occupational Exposure to Hazardous Chemicals in Laboratories, 42 Occupational health and safety information, sources of, 26-30 Occupational health and safety programs, 18, 22 costs of, 5, 30-31 developing, 4-5, 17, 23-31 elements of, 6, 106-122 participation in, 9, 11 - 13, 123- 124 Occupational health and safety risks. See Hazards Occupational health-care service, 6-7, 123-134 activities of, 129-133 limitations of, 133 responsibilities of, 125-129 Occupational health log data, 27, 29, 119 Occupational Safety and Health Administration (OSHA), 2, 7, 21, 25, 35, 41, 114, 121, 124 Occupations, categories of, 2 Orf disease, 34, 74-75 Orientation. See Education and training Ornithosis. See Psittacosis Orthopox virus. See Monkeypox INDEX OSHA. See Occupational Safety and Health Administration (OSHA) OSHA Form 101. See Supplementary Record of Occupational Injury or Illness (OSHA Form 101) data OSHA 200 log data, 27-29, 119-120, 127, 134 Osteomyelitis, 34 p Paramyxovirus infection. See Newcastle disease Parrot fever. See Psittacosis Personal protective equipment, 14, 17, 41, 49, 63, 111-114 Pesticides, 42-43 Physical examinations, 7, 9-10. See also Evaluation, of workers Physical hazards. See Hazards Pigs. See Swine Plague, 89-90 Pneumonitis, 59 Poxvirus diseases. See Benign epidermal monkeypod; Monkeypox; Orf disease Preexisting conditions, 60-61 Primates (nonhuman), 33, 46-47, 58, 76- 77, 85-87, 94-95, 97, 99, 102-103 Priority-setting of hazards, 24 Professional societies, 25 Protective equipment. See Personal protective equipment Protozoal pathogens, 95-99 Prudent Practices in the Laboratory: Handling and Disposal of Chemicals, 42, 44 Psittacosis, 46, 87-88 Public Health Service, 7 Advisory Committee on Immunization Practices (IPAC), 132 Public Health Service Policy on Humane Care and Use of Laboratory Animals, 124 Pulmonary function, monitoring, 61, 64 Pustular dermatitis. See Orf disease

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INDEX Q Q fever, 14, 46, 65, 81-83 R Rabbits, 47, 56, 85, 95, 99, 103-105 Rabies virus, 34, 79-80 Radiation, ionizing. See Ionizing radiation Radioallergosorbent test (RAST), 61 Radioisotopes. See Hazards, biological Ranking hazards, 26 RAST. See Radioallergosorbent test Rat-bite fever, 34, 47, 88-89 Rats, 47, 54-55, 91, 102, 104 Recordkeeping, 4, 13, 15, 116, 132 Refresher training. See Education and . . trammg Regulatory requirements, 2, 5, 7, 24, 112, 127 Reporting requirements, 15, 20, 131-132 Reptiles, 60, 93. See also Envenomation Research,4,18,21 complexity of, 43-44 protocol-related hazards of, 5, 7, 43-50 reviews of protocols, 25, 115-116 Resource development. See Occupational health and safety programs, costs of Respirators, 63, 109-111, 114 Responsibility and accountability, 4, 15 17 Restraint, 68, 113. See also Chemical restraint Rhesus monkeys, wild-caught, 67 Rhinitis, allergic, 53-54, 59-60 Rickettsial pathogens, 46, 81-85 Risk assessment of, 4-9, 13-14, 20, 24-30, 125, 127 defined, 26 Rodents, 99. See also Guinea pigs; Mice; Rats wild, 71-72, 84, 89-90, 104-105 Rubeola. See Measles Rules and guidelines, 4, 13- 15 153 S Safety awards, 23 Safety bulletins and reports, 25 Safety cabinets, 109-111, 117 Salmonellosis, 47, 92-94 SALS. See Subcommittee on Arbovirus Laboratory Safety Scratches. See Hazards, physical Screening programs, 60-61, 126 SDS. See Supplementary Data System (SDS) data Sedation. See Chemical restraint Septic arthritis, 34 Serum collection, 7, 9-10, 126, 132-133 Sharps, controlling, 34-35, 48, 111 Sheep, 46, 59, 74-75, 81-82, 85 Shigellosis, 47, 94 Simian immunodeficiency virus (SIV) infection, 46, 78-79 Site inspections, 20-21, 25, 116, 134. See also Animal care and use programs SIV. See Simian immunodeficiency virus (SIV) infection Snake bite, 34 Sporotrichosis, 47, 100-101 Stomatitis virus, 46 Subcommittee on Arbovirus Laboratory Safety (SALS), 45, 70 Supplementary Data System (SDS) data, 27-28 Supplementary Record of Occupational Injury or Illness (OSHA Form 101) data, 28-29 Surveillance programs. See Medical- surveillance programs Susceptibility of employees, 7, 127-128 AIDS-related, 98 Swine, 46, 58, 85, 90-91, 97, 99, 103-104 T Tanapox. See Benign epidermal monkeypod Tennis elbow, 40 Tenosynovitis, 34 Tetanus, 34

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154 Tissue-preserving chemicals, 42-43 Toxic chemicals, 42. See also Hazards, chemical Toxoplasmosis, 95-97 Training. See Education and training Transgenic animals, 48 Transplantation, 66 Tuberculosis, 47, 85-87 Tularemia, 34 U Ultrasonography, hazards associated with, 41 Ultraviolet (UV) radiation. See also Hazards, biological biocidal use of, 117 classification of, 36-37 Urticaria, contact, 52-53, 60 U.S. Army Medical Research Institute for Infectious Disease (USAMRIID), 83 U.S. Nuclear Regulatory Commission, 39 USAMRIID. See U.S. Army Medical Research Institute for Infectious Disease (USAMRIID) U V. See Ultraviolet (UV) radiation V Vaccinations, 74, 76-80, 87, 90, 124, 126, 132 Ventilation systems, 62, 107- 108, 117- 118 INDEX Vesicular stomatitis virus, 46 Veterinarian, staff, 18, 20-21, 115, 127 Viral pathogens, 46, 66-81. See also individual viruses Visibility, impaired, 36 W Walk-through. See Site inspections Welts. See Urticaria, contact Wheezing. See Edema, laryngeal Work environment. See Exposure, controlling Worker compensation data, 26-28, 119, 127, 132, 134 Workplace diversity. See Occupational health and safety programs, participation in Work practices. See Laboratory safety X Xenograft transplantation, 66 y Yersinia infection, 95 z Zoonoses. See Hazards