Below is the uncorrected machine-read text of this chapter, intended to provide our own search engines and external engines with highly rich, chapter-representative searchable text of each book. Because it is UNCORRECTED material, please consider the following text as a useful but insufficient proxy for the authoritative book pages.
Appendix F EFFECTS OF ADMINISTERING ASBESTIFORM FIBERS TO ANNALS Content s . Table F-1: Respiratory Tract Tumors in Rodents after Inhalat ion of Asbestos and Ocher Asbestifo~ Fibers Table F-2: Tumors in Rodents After Inhalation or Intratrachea1 Instillation of Asbestos in Combination with Other Chemicals Table F-3: Mesotheliomas in Rodents Appearing After Injection of Asbestiform Fibers Table F-4: Development of Fibrosis in Animals After Inhalation, Intratracheal Instillation, or Pleural Injection of Asbestos and other Asbestiform Fibers The references given on these tables can be found on the list for Chapter 6. 300 ..
301 ~: : . a, 4~1 at ~"i "~ " ~-1 ~ "1' ~ ~ ~ ~ ~i. o ~ 0 ~> - ~a ~a ~- - . - - - V ~ g ~I ~ ~1 8 ° I ~S ~, ~ D `,, ~ ~ ~ ~V ~ a ~ ~ O c) v ~ ~ ~ ~ ~v -= I ~ = a 3 ~^ ~-= - 8 0 ° ° 0 ~ v 3 ~ 0 ~ 0 ° ~1 9° 0 ~ ~ He -~ ~ 8 °a a a a ~a ~ of 0 o ~ 0 c,~c D ~ C 0 ~ O e ~e a 8 ~0 0 · 0 0 c z _ ~ 0 ~ - ~8~ ~ 0 - 0 ~ ¢ 0 0 · ~0 E" Z ~ _ at. v a cat on I ^ At. J 00 ~ ~O ~ E" 0` 1 Cat l _1 Cot ~ a ~ - c~ - o ~- to ~ ~ - ~ o ~ o - ~ ~ ~ - m - o - - o ~ ~ ~ ~g ~ ^ m ~ ~ ~^cr' ^o o~s^ - ~. ~ - ~+ ~-~ o ~- ~- o- - ~ ~ ~ ~ ~ ~ o u-' - ~ - ov - ~x ~- ~ ~c~ ~ c ^ to s Do ~e ~ - ~ ~ ^ - ^ - - ^~~ - o ~ - ~ ~ - M eJ O -D t~ V C' ~ ~ ~4 D - ~· ~ :^ . ~ ^~ - ~O `0 ~ ·^ 0 ~_ ~ - _ 0 _:o ~-0 ~~~ am_ ~ ~ O- ~- ~ 0 ~ - _ ~ ~ ~ :~ <:_ CL<: S: ~ 00 ~^ ~CO C~ ~ O ~ __ · ~ 0 ~ - 0 · __ O ~ s0 00 ~ - 0 8 D . ~ r~ :^ e~ O · · ~ ~ O O ·- ·,t ^ ~ ~ ~ D D -- ~ ~ :^ ~ ~ ~ "^ C" - __ _ ~ . O~ O . _ O ~ C, ~^ C · ~"CO· ~ O ~O~~0 ~ .^ · 0 ~ - ~00 ~V O ~ C ~ ·_ ~ __ 0 ·0 C .0_ ~ O ~ #~ - _ E" D id D .~m dV c~em-_ o.~o . c~ · - _ ~o 0 0 ~ :' _, _ ~o _ ~ _ 0 oo oo ^o 8 · - ~- J~ . 1 am 1 ~ ~_ _ ~ aC "S · C~ a ooe ~ ~ ~ z
302 ~. 0 - ,g j ·1 ~ouII a~ ~ a ,, ~00 at @ - a. ~ 0 elm - - ~ ~ - o0 - > - O ~ ~"0 a: ~O ~ ~=0 ~ I,, O O 10 ~ ~U :^ ~ ~ ~ ~ ~" - ~ ~ ~ 8 c ~ o ° ~ ~0 ~ ~o ~o - " ~o ~ ~ ~ ~ e I: ,,, ~ At, ,, u ~ 63 0 ~,, - , D ~ C) C) 00 Ad: ~or 0 a ~3 0 ~ so ~" - cat v 0 0 To ", ~Ye ~0 0 ~ ~:, ~ 2 ~3: ~: ~ O 80 00 -. O ~' o ~o ~ _ O ~ ~·^ ~O ~ O- Z ~3 ~·^ 0 0 U O ~ ~ ~ OC ~0 ~ 64 V - 1 0id 0a ~ O~ ~ql O ~o~ ~ E"~ ~ CJ 0 ~ o00 O ~ ~ ~ ~O O O ~ _ . ~-- ~+= ~·- ~^O~m o ~mm ~ ~ za ~= 0 .0. ~ ~ cn. 0D D ~ 1` Q al ~ ~ 00 - ~ _. _ ~a,0 _ :^ 0 ~ I C ^ ~ ~0 0 t. ~ "~ a1 ~ ~ · ~ ~21 .2 ·~m ~0 a OO ~ ~ O . ~ ~ 0 0 ·- _ oa ~ "~ ~ ~ ~ 0 o ~ 0 ~1= . · ^ ~ 0 C ~ C, ~g t' 0 - v 3 st3 ~ `' ~ ~ s ~c, ~ ~ ~
303 0 C) tic i it -;1 i i -;1' ~ 4~" ~"i . ~0~ ~ ~- O ~ ~ I.4 I~l A; ~1 ~ (V or to or ~ or ~ cr. 3 ~ ~a ~ - o c al ~Hi 0 ~ O O ^ ~ ~ ~3 ~ ~g ~: o o, ° ° g o c~ V ~ -~ 8 _t ~ ~ 0 0 O ~ O ~0* ~ 0 0 V 0 - 1 ~tS1 ~0 ~ 0 0 ~ _1 {a, ~ c~ s0 °e ~o C~ 8 v e ~ ~ `, E ~O ~ ~ ~ ~0 ~0 V ~O c o ~ v ~ ~ ~a~ o O L ~O ~O ~O ~, ao V& a ~a~ cv a~ ~ 0 o O =0 Y C ~ ~ 8 C" C~ ~ z a a+ ~ ~ =+~ + + +, ~ _ + +_= _ - - ~- ~ ~ D _1 ~_1 -~ · ~_tC~ ~O -~ _1_ ~J ~_~- O _ ~ts - - -O _ _~ ~ ~_ 0 ~cr 0 ~_ u^, ~ O ~0 o 0 ~ ~a ~ 20 ~o ~ ~ ~ O 0 8 P ~4 Pc C~ ~1 Z 0 ~- ~0 e _ _ - - ~ ~ ~ 0 . ~O ~ . ~ 0 ~0 ~ 0 z eo O r ~a e ~;~; ~0 ~ ~ ~ _~_ C ~0 ~ ~° ~ ~ ~ g o Zl~l ~o 0 0 _- c ~ _ -- ~o o1 ~ 1~1 1= oo -~| ~ 1~1 tOa . i l l ; - .,
:^ 0 b ~0 · - ~0 ~E ~ · - C CL- o o r, O K . o Z L _ 0 D ~ . - O E ~ :^ ~ _ o 0 · o o E Z _ 0 c · - E o - - s o oo ~C ~_ ~·V 1 O 0 ~0 t~_E ^ ~ V ·t ·64 _ ~ ~_ Ev _ <:_~ "= _ ~C C- o CO~ C,, o ~ oo o C: ~ o ~ o . -_ ~o V O _ o ·- Ev c o ~C ~o ~: 0 ~ - ~ ~ ·^ ~· - o E K E o · - 0 om E · - C o C ~· - U~ f ~E o .~ E ~ E - ^ ~ ~ 0 e' ~ ~ o ~ ~ ·-d E ~^ 0 0 ~ ~C,'- - ~ ~ ~ E t" ~ _ ~ ~ ~ "" ~^ E e ~ ~^ :~:= tn . _ U~ 00 0 V ^V ~e~ _ - 304 o~ - v v v E · - so C~ IL,
305 _ ,` ~o _ ~_ ~_ o, ~o~ _ '% _ ~v ~_ ~-1 o ~. q, j D V0` C ~_C ~C ^ C q, 0 ~,c {:C ~00 C,} ~ b0CO ~.- t~O ~O O E ~:3 ~t~ _ _ v _ Ll u J 1 . ~bO o ~ v Otn _ ~C ~~ v O D I ~ ~ ~g _ ~ o0 E C ~ . ~ ~O 0 ~ _ Z ~ _ ` ~c~_ _ ~ _ _ E v E ~v v ~v v 0E <1 ~= ~4 | to o o, ',, ~ ~ ~E c E O _ _ ~v ~ ~ ~ E E ^ v ~ .- X .. ~I ~ r r ~ c ~c v ~ ~.u E o O _ O u~ S O E ~ E r 2 ~ ~t: O '~ t O ~·- C ._ ~ ~ _ _- v c 0 0 Z ~ I ~ O ~r s c c C ~ .- v- ~ ~, O ~ _ O ~ O _ v' ~r E >, I ~ ·c Co ~c _ ~ v c ~. 'q ~t~ ~ ~ ~_ ~ ~0 = ~ ~ O ~ ~ ° ~r o I ° ~ ~ r ~ 0 . - ~_ _ . - ~ ~o ~ ~ E-- ^ ~ ^ O- ^ E 0 ~.= ~ E ~ ~ 3 v ~ + v ~- ~ ~_ ~ ~ ~ ~ v E E ~- o OE 3 u, a ~ ~ ~ ~ ~ ~=. - ~ ~ ~ ~ ~ ~ O ^. - v ~ _ Z ~X ~- {, ~ _ C ~ 1 o ~ ~_ - ~E ~ E . - ~E ,E E v ~~~ 0 ~v _ 0 _ _ E _ _ O C ~ ~_ 0 ~_. - -~_ . ~ O O ·- O o O C ~_ ~C ~_ o' ol °I--l v -1 -1 ~1 ~ ~ o 1 v ~ ~ . ~-o.-l -~1~1- ~ c ~ v 0 _ ~-- ~ ~ ~ ~o ~ ~ ~ _ 0 ~ _
306 D to 0` 0 C) 0 ~ S C C O _ o 0 L. 0 O O X D - 0 o to · O O Z ~ E 1 o ~O Cat 0 ·e · - ·. Pe Cat :~^ ~0 0^ 0 · O ;' · ~ - 1 - 1 ~1 ~1 - 1 ~1 ~1 ~1 V ~ ~: ~N U) ~U) `0 ~~ to ~ 0 _ _ .~ S At: I.. ~C ~ o Cal LIZ ~ CI, CO o o ~ i., · C:' ~ ~ o ·~" ~ ~ a, ~ . JO ~ ~ ~ Let · ·. ~ _ BE O · ~ ~ "~ O on O ~ e ~ ~ - . ~ ·- ·. ~ · - ^ · ~ ~ oco - ~ o o ~ c~ - ~ - ~ ~ u o o ~: JJ o ~ o 0m o ~ ~o . :o Ld s c, o 0 o ~ s 1 0 ~: :, o ~4 D v e °C C) 0 ~o ~_ 0 o 0 ^ ^_ C' ~ U. - r~ ~C ~^ ^ ~ -1 -1 -1 ~ ~, ~ "1 - 1 "1 c ~1 ~1 ~1 ~ 0 0 0 P4 P4 ~0 tlo ~ ~ r~ ~ ~ ~ C~ ~-1 ~: ~ ~S ~ S ~. - _ ~ _ -~ 13 ~- .- ^o ~ o 0 O - ) V b b ~1 _ _4 D O _ O - C~ O Z a0 0 ^ ~C~ ^ ~:' _ ~ ~ · ~ - ~ ^ C O ~_ ^ ~ _ =, ~ ~ _ V _ ~-~ O O~ _ - ~· ~ C O O V _~ _ ~_ ~C~ ~ 0 _' ^ `= V ~ ~- ~ s0 - - _ ~^ ~ ~0 O · - ~ O O ~ _ 3 0 1` ~, ~ _' u~ ~ O _1 ~-* ~ ~ ~ ~ _ o ~ ~_ _ ~ ~C. C ~ ~C- =: ~: ~S: ~ ~-: ~ v o ,' . ~D ' :^ o 0 0 0 ~ Ck 0 90 ~ ~0 ·.b U~ _ C~ O ~ _ 5: _ C~ s0 ~ ;3 00 _ so s: ~ b D · O t0 ~D - 0` - :~: ~e 00 ~ V V so ~ ~ ~~_ _ 1 ^o 0 0 ~^ ^ 0 ~00
307 c e~ o~ - . -1 ~1 vl ~1 v v o C~ - C) t: V C ~ 8 ~ =_ Z - E . - ~ C q5 o a, - E · - <: ~ 0 o K · o Z ~ _ s" 0 ~ D O · - E ~ :- O o' o 8 Z ~ - . V C o o ~ · - _ 1 o ~ ~ C _ ~ · - D ~ E ~ o ~ o~ - -1 '11 vl ~1 o v y E~ ~ V tC · - ~ o3 ~ ~V `.1= 0 ~ ~ O 0 ~ ·~= Z D ~C: · - ~D C 0 _ ~ S~ ql _ O E ~ E ~.- . - o E u~ ~ _ o ~ · U oo C V O :^ . - v ~ ~ . - · tJ 0 E 0 . - o ~o E _ 0 o - o c o v _ C O _ C oo o :^ - · - _ o ~ _ _ ~E oo o - _ ~4 _ _ r~ ~4 _ - c~ ~ ~ ~ - c., ~D ~ - ~e X · - · - ~ ~ ~ L~ e - 4 _ _ _ O _ _ __ - 0 ~ _ _ Z ~ O _ )- ~ V C ~ ~e 10 o eo e~ · - ~D 0 o o ~D 0 e, o C es D U) e~l e$ - ~e 0 00 eO ~ ~ · - _ 0 tI0 ~ 80 0 C ~ ~ _ ·~4 - .e4 0 ~d (U · - - e. O ~ E e ~O |D ~ O · - E 0 11 e ~ 0 _ ~ ~ _ e. eho p~e e E" ~ ~ C 3 ~ ~ E- , . - _ o o E e~ U) · _ _ ~ ~ 0 V D 0 ·64 0 11_ ~S~e _ 3 e._ CID cn sc 0 _ ~ D E E ~ _ o o ~ o eCl · - U O e. 3 ~ e" · - 0 t, L 0 V be 0 -0 ~ ·~4 00 ~ _ "~4 ~ O ~ _ · - ·rl Sle _ O O eD E E ~ ^, 3 ke ~C ~ t., _ n E 0 - e. ~ C · - ·rl _ O eO ~ 4 e~e eD o 0 C) o e~e ~e e" ~ ^ ·" o E ·- (U e~ U ere L' c,, v E C~ U~ H en . o . - ·-1 c -4 c · - ~o ee ~ ~ie_ 0 _ ~ ~ V _ e4 eD . -e. O t*4 ~ e~e 0 0 e~ :^ 0 ~ t3D ~ ~ ~ ~ C Ze 0 D ~ O _~ - _ Z tlO 1 0 U 5e. .rl E u eD .. l
o ~ o o ~ = ~ = ~ o lo c = ~ 308 o - C .- , _ HI fly ~- o . ~ . .- ~ e a 0 ~ 'a: .- O m ~ O -- _ ~ > 0 ~ O _ Cal O O 5 ~ ~o
309 c 0 c o e" 0 D o _~ S C O ~ E Q _ Z E C ~e C o ·~4 v V - C ~ ~ E _ C bC o E ~ _ C o _ U c · - - , _ - ~ o E ~ 3 E ~0 3 ~ ~ ~ vl E C o ^ ~ 0 _ C ~ ~ · - ~ D D ~ C3O · - o' O 2: ·. ^ ~D~ - :~ CL r~ o o · - C C · - o O - ~ ~4 :~ . - _ O D · - S CL :^ E N 0 · - U) C ~_ 0 0 ~01 _ _ - . -1 Vl C ~_ 3 I~ eD .." CL E ~ C · - CD ~: I- vl ~)1 ~o oo _ :B V _ o 0 so o~ ~D- · - - c ~ · - - ~ ~e C~ D :^ s 2 E _ bC_ E ~ O . - 0 0 0 ~ O O ~ Y 3 _ "0 ~ ~ K - ~ ~ ~o E C~ U ~0 E 0 _. 0 o _ U, - o _ _ ~ ·- ~ C. · - ~ o o . - E _
310 ~: 0 C 0 0 o . - . - - o o aD D ~. - · - 0 O O O Z Z _~ : - U e ~ ~ C ~ ~ C) Z v ~_ _ ~:^ E . - E c C ~o c o . - dJ ~ D ~ _ C ~ E C} _ 0 ~ - o o o C ~o ~ e _ ~ 0 _ E . E ." 0 ,~ · - _ · ~ E E ~ E ~ ~ C ~ E ·- ~ o ~ _ ,,~ _ ~ ~E E ~ ~ ~_ ~ 1 ~ . ~ E O E ~ o o ~ ~ o ~ ~ ^ _ ~ ~ o ~ -1 - .1 o o ~ ~Y - - E ~_ . - _ O ~ · - ~o o U ~3: _ _ 0 ID ~ :^ o ~ ~ ~ o 0 C~ :^ C, Cd I- .. o ~ _ o ~C o~ _ 0 V S o . - 0 a- - ~· - 0 o~ ~o Dle . - ~O ~ ·- OU C:~ . - 0K '.4 0 00~ 0 IOJ E ~D D O ~ts4 ~ · - ~ vC ~ 0·^ - - Eo E ~o ~ ~ _ __ o C ~o _. - ~CL Oo · - K Z O ~ -0 ~O U 0 C: U) ~e .- ~ ·^ V _ ~ ~o" O O _0 0 O ~ · E ~ o _ CK.- 0 ~ ~D ~ v E ~C o ~ ~·- CL ~ 3 E~ . - 5 _ . - · - · - _ >~ V . - V ~-· - o O ~ E _ 0 e ~ ^ so .,~ 0,! o_ _ so ~Z ~ '- E ~ ~ ~ ~ _ . o ·- ~-~-ua 0 ] tU- 0 ~ ~ · - .," ~ ~ ~· D - C 0 0 V. - O ~ ~ ~V ~ ~ ~ ~ O · - ·~04 id ~ ~ _ U ~ ~ 0 ~ ~ O ~ O ~ - E ~ v U ~ ~ K Cee4 . - ~ ~ . - v 0 ~ C C O C~ ~ ~ · - ~ ~ O ~ · - C .- ", - ~ a0- - ~ _ _ ~ ~ ~ O · - ~ O ~ ·-- - ~ C 0 C :^ ~ O ~ ~ ~ ~ ~ V =_ C e._ _- - O O "" ~ Z 0- - ~ ~ ~ eC ~ ~ 1~ U ~J D U