companion animals, and animals in laboratories and on farms. HSUS publishes a quarterly magazine (The HSUS News), a newsletter (The Animal Activist Alert), and a variety of reports, brochures, and other advocacy materials. The society works actively on issues involving the use of animals in research, safety testing, and education. This work is spearheaded by the HSUS Animal Research Issues Section, with the aid of a Scientific Advisory Council. The aims of this research are to promote the 3 R's of replacement, reduction, and refinement; strong regulations and their enforcement; openness and accountability among research institutions; and an end to egregious mistreatment of animals. HSUS pursues these aims through educational, legislative, legal, and investigative means. Staff are available to give presentations and write articles on these topics.

Institute of Laboratory Animal Resources (ILAR), National Research Council, National Academy of Sciences, 2101 Constitution Avenue, NW, Washington, DC 20418 (phone: 202-334-2590; fax: 202-334-1687; e-mail: ILAR@nas.edu; ILAR Journal e-mail: ILARJ@nas.edu; URL: http://www2.nas.edulilarhome).

ILAR develops guidelines and disseminates information on the scientific, technologic, and ethical use of animals and related biologic resources in research, testing, and education. ILAR promotes high-quality, humane care of animals and the appropriate use of animals and alternatives. ILAR functions within the mission of the National Academy of Sciences as an adviser to the federal government, the biomedical research community, and the public. ILAR Journal is published quarterly and is distributed to scientists, biomedical administrators, medical libraries, and students.

International Council for Laboratory Animal Science (ICLAS), Dr. Steven Pakes, Secretary General, Division of Comparative Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX (phone: 214-648-3340; fax: 214-648-2659; e-mail: spakes@mednet.swmed.edu).

ICLAS is an international nongovernment scientific organization that was founded in 1961 under the auspices of UNESCO and several scientific unions. The aims of ICLAS are to promote and coordinate the development of laboratory animal science throughout the world, to promote international collaboration in laboratory animal science, to promote the definition and monitoring of quality laboratory animals, to collect and disseminate information on laboratory animal science, and to promote the humane use of animals in research, testing, and teaching through recognition of ethical principles and scientific responsibilities.

ICLAS has programs addressing microbiologic and genetic monitoring and standardization, assisting developing countries in pursuing their objectives in improving the care and use of laboratory animals, and improving education and training in laboratory animal science. ICLAS accomplishes its goals through



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