research with hazardous agents and occupational health and safety are considered in Chapter 1. Recommendations for farm animals are incorporated throughout the text where appropriate.

This edition of the Guide is divided into four chapters and four appendixes. Chapter 1 focuses on institutional policies and responsibilities, including the monitoring of the care and use of animals, considerations for evaluation of some specific research procedures, veterinary care, personnel qualifications and training, and occupational health and safety; the latter section summarizes another National Research Council committee report (NRC In press) and includes information about facilities and procedures for animal research with hazardous agents. Chapter 2 focuses on the animals themselves and provides recommendations for housing and environment, behavioral management, husbandry, and population management, including discussions of identification, records ,genetics, and nomenclature. Chapter 3 discusses veterinary medical care and responsibilities of the attending veterinarian; it includes recommendations relative to animal procurement and transportation, preventive medicine, surgery, pain and analgesia, and euthanasia. Chapter 4 discusses the physical plant, including functional areas and construction guidelines, with expanded discussions of heating, ventilation, and air-conditioning (HVAC) systems and facilities for aseptic surgery.

The appendixes in this edition remain largely the same as in the preceding edition. Appendix A contains an updated bibliography, categorized by topic; Appendix B lists selected organizations related to laboratory animal science; Appendix C presents federal laws relevant to animal care and use; and Appendix D provides the PHS endorsement of the U.S. Government Principles for the Utilization and Care of Vertebrate Animals Used in Testing, Research, and Training (IRAC 1985).

REFERENCES

CFR (Code of Federal Regulations). 1985. Title 9 (Animals and Animal Products), Subchapter A (Animal Welfare). Washington, D.C.: Office of the Federal Register.

Consortium for Developing a Guide for the Care and Use of Agricultural Animals in Agricultural Research and Teaching. 1988. Guide for the Care and Use of Agricultural Animals in Agricultural Research and Teaching. Champaign. Ill.: Consortium for Developing a Guide for the Care and Use of Agricultural Animals in Agricultural Research and Teaching.


IRAC (Interagency Research Animal Committee). 1985. U.S. Government Principles for Utilization and Care of Vertebrate Animals Used in Testing, Research, and Training. Federal Register, May 20.1985. Washington, D.C.: Office of Science and Technology Policy.


Leader, R. W.. and D. Stark. 1987. The importance of animals in biomedical research. Perspect. Biol. Med. 30(4):470-485.


Midwest Plan Service. 1987. Structures and Environment Handbook. 11th ed. rev. Ames: Midwest Plan Service. Iowa State University.


NRC (National Research Council). 1977. The Future of Animals, Cells, Models. and Systems in Research. Development. Education. and Testing. Proceedings of a Symposium of the Institute of Laboratory Animal Resources. Washington, D.C.: National Academy of Sciences. 341 pp.



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