plant. Responsibilities of institutional officials, institutional animal care and use committees, investigators, and veterinarians are discussed in each chapter.

In 1991, an ad hoc committee appointed by the Institute of Laboratory Animal Resources (ILAR) recommended that the Guide be revised. The Committee to Revise the Guide for the Care and Use of Laboratory Animals was appointed in 1993 by the National Research Council; its 15 members included research scientists, veterinarians, and nonscientists representing bioethics and the public's interest in animal welfare.

Before revision began, written and oral comments on the Guide were solicited widely from the scientific community and the general public. Open meetings were held in Washington, D.C., on December 1, 1993; in San Francisco, California, on February 2, 1994; and in St. Louis, Missouri, on February 4, 1994. Comments made at those meetings and written comments were considered by the committee and contributed substantially to this revision of the Guide.

The committee acknowledges the contributions of William I. Gay and Bennett J. Cohen in the development of the original Guide. In 1959, Animal Care Panel (ACP) President Cohen appointed the Committee on Ethical Considerations in the Care of Laboratory Animals to evaluate animal care and use. That committee was chaired by Dr. Gay, who soon recognized that the committee could not evaluate animal care programs objectively without appropriate criteria on which to base its evaluations; that is, standards were needed. The ACP executive committee agreed, and the Professional Standards Committee was appointed. NIH later awarded the ACP a contract to "determine and establish a professional standard for laboratory animal care and facilities." Dr. Cohen chaired the ACP Animal Facilities Standards Committee, which prepared the first Guide for Laboratory Animal Facilities and Care.

The Committee to Revise the Guide for the Care and Use of Laboratory Animals expresses its appreciation to the Animal Welfare Information Center, National Agricultural Library, U.S. Department of Agriculture, for its assistance in compiling bibliographies and references. This task would have been quite formidable without their help. Appreciation is also extended to the reviewers of the volume, to Norman Grossblatt for editing the manuscript, to Carol Rozmiarek for providing exemplary secretarial assistance and preparing multiple drafts, and to Thomas L. Wolfle, who managed the process from beginning to end.

Readers who detect errors of omission or commission are invited to send corrections and suggestions to the Institute of Laboratory Animal Resources, National Research Council, 2101 Constitution Avenue, NW, Washington, DC 20418.

DERRELL CLARK, Chairman

Committee to Revise the Guide for the Care and Use of Laboratory Animals



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