Agent

IARC Classificationb

Occurrencec

TD01d (mg/kg-d)

N-Nitrosodiethanolamine

2B

S: Impurity in herbicide atrazine; contaminant in cutting fluids and some cosmetics

3.57E-03

N-Nitrosomethyl-vinylamine

2B

N: Derived

6.25E-05

N-Nitroso-N-methylurethane

2B

N: Derived

9.09E-05

Polybrominated biphenyls

2B

S: was flame retardant; now minimal and localized food chain contaminant

3.33E-04

Ponceau MX

2B

S: Was drug and cosmetic color in US; used as a food colorant elsewhere

2.22E+00

beta-Propiolactone

2B

S: Industrial use

7.14E-04

Reserpine

3

N: Indirectly added veterinary drug

9.09E-04

o-Toluidine

2B

S: Chemical intermediate (e.g., pesticides, dyes); N: constitutive

5.56E-02

o-Toluidine hydrochloride

(2B)

S

7.69E-02

a Agents identified by IARC as known (1), probable (2A), or possible (2B) human carcinogens or by the NTP as known or reasonably anticipated to be carcinogens (NTP K or NTP R, if the agent has not been classified as 1, 2A, or 2B by IARC).

b For definition of terms and overall evaluations, see Preamble, pp.28-29 (IARC 1993).

c Where possible, synthetic agents (S) are distinguished from naturally occurring (N) (as defined in Chapter 1). Naturally occurring agents are subclassified into constitutive, derived, acquired, or added (as defined in Chapters 1 and 2).

d The TD01 is the chronic dose in mg/kg/day causing a 1% increase in tumors in experimental animals.



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