TABLE A3-1 In Vitro Assays of Electric-and Magnetic-Field Exposure and Genotoxicity

Study

Cell Type

Exposure Characteristics

Electric-Field Strength of Culture Media

End Points Evaluated

Outcome

Hungate et al. 1979

Salmonella TA100 or TA98 exposed 20 hr in liquid nutrient broth suspension

200-800 kV/m electric field in air

Cannot be determined from report

Mutation

1.5-3-fold increase in mutation frequency in TA100 at 800,000 V/m

Moore 1979

Salmonella TA98 and TA100 tester strains exposed during growth in nutrient broth for 5-24 hr

0.3-Hz triangular magnetic field at 0.015 and 0.03 T

Induced electric field cannot reliably be estimated from report

Reverent assay

No significant effects observed

Wolff et al. 1980

CHO cells exposed 4 hr (SCEs) or 13 hr (chromosomal aberration)

NMR gradient field; 1.82 pulses/sec, 4.6 T/sec; coexposed 0.352-T static magnetic field and 5-mW/cm2 magnetic field at 15 MHz

Cannot be determined from report

Chromosomal aberrations and SCEs

No significant effects observed

Wolff et al. 1980

CHO cells exposed 4 hr (SCEs) or 13 hr, 40 min (chromosomal aberration)

0.35 T plus coexposure to RF field at 15 MHz, 5 mW/cm2 and time-varying magnetic-field changes at 4.6 T/sec and 1.82 T/sec

0

Chromosomal aberrations and SCEs

No significant effects observed

Cooke and Morris 1981

Human lymphocytes exposed 1 hr

0.5-1.0 T

0

Chromosomal aberrations and SCEs

No significant effects observed



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