| ||||||||||||||||||||||||||||||||
|
|
|||||||||||||||||||||||||||||||
Below are the first 10 and last 10 pages of uncorrected machine-read text (when available) of this chapter, followed by the top 30 algorithmically extracted key phrases from the chapter as a whole.
Intended to provide our own search engines and external engines with highly rich, chapter-representative searchable text on the opening pages of each chapter.
Because it is UNCORRECTED material, please consider the following text as a useful but insufficient proxy for the authoritative book pages.
Do not use for reproduction, copying, pasting, or reading; exclusively for search engines.
OCR for page 35
-->
3
Toxicology
This chapter is an update of the toxicological information that appeared in Chapter 4 of Veterans and Agent Orange: Health Effects of Herbicides Used in Vietnam (IOM, 1994). The chapter begins with a summary of the new information presented and a summary of information presented in the previous report. This is followed by an overview of the toxicological profile updates on 2,4-D; 2,4,5-T; cacodylic acid; picloram; and TCDD. The toxicological profile updates on these five substances are a review of the results of experimental studies published during the period 1992-95 and comprise the remainder of this chapter.
Summary
Introduction
In this section, we summarize information on the following:
Toxicokinetics: the way in which dioxin and the herbicides enter and leave the bodies of animals; that is, the way these substances are absorbed, distributed, metabolized, and excreted by animals;
Mechanism of action: the way in which dioxin and the herbicides act on the body to produce a toxic effect; and
Toxicity: the toxic effects from exposure to dioxin and the herbicides on laboratory animals and nonhuman systems.
Understanding how dioxin and the herbicides affect animals and nonhuman
