A
Workshop Agenda

Xenograft Transplantation: Science, Ethics, And Public Policy

June 25-27, 1995

Bethesda Hyatt Regency Hotel—Crystal Ballroom

1 Bethesda Metro Center, Bethesda, Maryland

Sunday, June 25

9:30 a.m.

Welcome and Introduction;

Kenneth I. Shine, IOM President;

Karen Hein, IOM Executive Officer;

Norman Levinsky, Committee Chair

Session I: Assessing the Science Base

9:45

Moderator's overview of session; Keith Reemtsma

10:00

Immunology: The Early Responses; Jeffrey Platt

10:15

Immunology: The Long-Term Responses; Thomas Starzl

10:30

Issues; Olga Jonasson

10:45

Discussion

11:00

Potential Therapeutic Approaches; Moderator: Denise Faustman



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OCR for page 103
--> A Workshop Agenda Xenograft Transplantation: Science, Ethics, And Public Policy June 25-27, 1995 Bethesda Hyatt Regency Hotel—Crystal Ballroom 1 Bethesda Metro Center, Bethesda, Maryland Sunday, June 25 9:30 a.m. Welcome and Introduction; Kenneth I. Shine, IOM President; Karen Hein, IOM Executive Officer; Norman Levinsky, Committee Chair Session I: Assessing the Science Base 9:45 Moderator's overview of session; Keith Reemtsma 10:00 Immunology: The Early Responses; Jeffrey Platt 10:15 Immunology: The Long-Term Responses; Thomas Starzl 10:30 Issues; Olga Jonasson 10:45 Discussion 11:00 Potential Therapeutic Approaches; Moderator: Denise Faustman

OCR for page 103
-->   Genetic Engineering Overview; Denise Faustman 11:15 Transgenic and Knockout; Beverly Koller 11:30 Transgenic Pigs; Steven Squinto 11:45 Discussion 12:15 p.m. LUNCH BREAK 1:00 Recipient Modification; Cellular Modification/Chimerism; Suzanne Ildstad 1:15 Nonmodification; Camillo Ricordi 1:30 Immunosuppression; Barry Kahan 1:45 Respondents and Discussion; David K.C. Cooper Ali Naji 2:15 Panel Status of Human Trials; Moderator: Nancy Ascher   David L. Cooper Keith Reemstma David Sharp 2:45 Discussion 3:00 BREAK

OCR for page 103
--> Session II: Infectious Issues—Moderator: Stephen Morse 3:15 Overview; Frederick Murphy 3:45 Emerging Pathogens; Stephen Morse 4:00 Discussion 4:20 Risk Assessment; Jonathan Richmond 4:30 Infectious Risk and Risk Assessment; Jonathan Allan Jay A. Fishman 4:50 Discussion 5:15 Adjourn Monday, June 26 8:30 a.m. Specific Pathogen-Free Environments and Nonhuman Primates; Michael Keeling 8:40 Specific Pathogen-Free Environments and Swine; Michael Swindle 8:50 Panel Discussion; (all speakers) 10:15 BREAK 10:30 Applications to Humans; Moderator: Marian Michaels 11:00 Surveillance and Public Health; Louisa Chapman

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--> 11:30 Detection Methods; David Persing 12:00 LUNCH BREAK 1:00 p.m. Panel Discussion (all speakers); Respondents: Jonathan Allan, Steven Deeks Session III: Ethics and Public Policy Moderator: Harold Vanderpool 2:00 Social and Political Issues; Moderator: David Rothman   Addressing Questions Raised by Xenograft Transplantation; Renee Fox   Commentary and Response; David Rothman Stuart Youngner 2:45 Discussion 3:15 BREAK 3:30 Economics and Allocation of Organs and Tissues   Economic Impact of Xenograft Transplantation: Lessons from Heart Transplantation; Roger Evans 3:50 Macroeconomic Aspects of Xenograft Transplantation; Paul Menzel 4:10 Who Gets Which Organs? Questions of Justice; James Bowman 4:30 Discussion

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--> 4:45 Clinical Trials Panel Discussion; Moderator: Clive Callender   Robert Arnold James Bowman Rebecca Dresser Stuart Youngner 5:30 Discussion 5:45 Adjourn Tuesday, June 27 8:30 a.m. Value and Use of Animals Panel Moderator: Ralph Dell   Susan Leaderer Justin Leiber Andrew Rowan James Walters 9:30 Discussion 9:45 Issues for Regulatory Review; Moderator: Robert Burt   Richard Merrill 10:15 Discussion 10:30 BREAK 10:45 The Patients' Views Panel; Moderator: John Robinson (counselor)   Gloria B. Liver transplant patient Brenda L. Project Inform Calvin W. Multiple transplant patient, and his mother, Evelyn W. Len K. Potential kidney transplant patient

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--> 11:45 Discussion 12:15 p.m. Wrap-Up; Norman Levinsky and Session Chairs 12:45 Adjourn Speakers And Panelists Jonathan Allan, D.V.M. Southwest Foundation for Biomedical Research Department of Virology and Immunology San Antonio, TX Robert Arnold, M.D. Associate Professor of Medicine University of Pittsburgh School of Medicine Pittsburgh, PA James Bowman, M.D. Professor Emeritus Department of Pathology, Medicine, and Committee on Genetics University of Chicago Chicago, IL Gloria Brooks Fort Washington, MD Louisa Chapman, M.D. Medical Epidemiologist National Center for Infectious Diseases Centers for Disease Control and Prevention Atlanta, GA David K.C. Cooper, M.D., Ph.D. Oklahoma Transplantation Institute Baptist Medical Center of Oklahoma Oklahoma City, OK David L. Cooper, Ph.D., M.D. Associate Professor of Pathology Department of Pathology University of Pittsburgh Pittsburgh, PA Steven Deeks, M.D. Assistant Clinical Professor of Medicine San Francisco General Hospital San Francisco, CA Rebecca Dresser, J.D. The Law School Case Western Reserve University Cleveland, OH Jay A. Fishman, M.D. Chief, Clinical Transplant Infectious Disease Unit Massachusetts General Hospital Boston, MA Suzanne Ildstad, M.D. Professor of Surgery University of Pittsburgh Pittsburgh, PA Olga Jonasson, M.D. Director, Education and Surgical Services American College of Surgeons Chicago, Ill

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--> Barry Kahan, M.D., Ph.D. Director of Immunology and Organ Transplants University of Texas Houston, TX Michale Keeling, D.V.M. Professor of Veterinary Medicine and Surgery University of Texas Cancer Center Bastrop, TX Len Koch The Health, Safety and Research Alliance of New York State New York, NY Beverly Koller, Ph.D. Department of Medicine University of North Carolina Chapel Hill, NC Susan E. Lederer, Ph.D. Associate Professor Pennsylvania State University College of Medicine Hershey, PA Justin Leiber, Ph.D. Professor of Philosophy Department of Philosophy University of Houston Houston, TX Brenda Lein Project Inform San Francisco, CA Paul T. Menzel, Ph.D. Interim Provost Pacific Lutheran University Tacoma, WA Richard A. Merrill, L.L.B. Daniel Caplin Professor of Law University of Virginia School of Law Charlottesville, VA Frederick Murphy, D.V.M., Ph.D. Dean, School of Veterinary Medicine University of California Davis, CA Ali Naji, M.D. Professor of Surgery The University of Pennsylvania Philadelphia, PA David H. Persing, M.D., Ph.D. Director Molecular Microbiology Laboratory Mayo Clinic Rochester, MN Jeffrey L. Platt, M.D. Professor, Department of Surgery Duke University Medical Center Durham, NC Jonathan Y. Richmond, Ph.D. Director, Office of Health and Safety Centers for Disease Control and Prevention Atlanta, GA Camillo Ricordi, M.D. Professor of Surgery Chief, Division of Cellular Transplantation University of Miami School of Medicine Miami, FL

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--> John D. Robinson, Ed.D., MPH Chief, Interdepartmental Treatment Programs Department of Psychiatry Howard University Hospital Washington, DC Andrew Rowan, Ph.D. Associate Professor, Environmental Studies Center for Animals and Public Policy Tufts University School of Veterinary Medicine North Grafton, MA David W. Scharp, M.D. Chief Scientific Officer Neocrin Company Irvine, CA Steven Squinto, Ph.D. Vice-President of Research and Molecular Sciences Alexion Pharmaceuticals, Inc. New Haven, CT Thomas Starzl, M.D. Professor of Surgery Director Pittsburgh Transplantation Institute University of Pittsburgh Pittsburgh, PA M. Michael Swindle, D.V.M. Director, Division of Laboratory Animal Resources Professor and Chairman Department of Comparative Medicine Medical University of South Carolina Charleston, SC James Walters, Ph.D. Professor of Christian Ethics Loma Linda University Claremont, CA Mr. Calvin Wilkins Rumsey Island, MD Mrs. Evelyn Wilkins Rumsey Island, MD Stuart Youngner, M.D. Department of Medicine University Hospitals Cleveland, OH