ALFRED GILMAN

February 5, 1908-January 13, 1984

BY MURDOCH RITCHIE

ALFRED GILMAN, AN INTERNATIONALLY renowned pharmacologist who died on January 13, 1984, will be remembered by countless scholars for his co-authorship of the seminal textbook on the pharmacological basis of therapeutics, by generations of medical students for his brilliant and inspiring lectures, and by his many friends for his warmth and concern for their personal problems. As for his scientific achievements, he played a key role in our understanding of how the ionic milieu of the body is maintained and he pioneered the first clinical trial that established the use of chemotherapy in the treatment of cancer.

Alfred Gilman was born in Bridgeport, Connecticut, on February 5, 1908. He graduated in 1928 from Yale College and remained as a graduate student in the Department of Physiological Chemistry, as many departments of biochemistry were called at that time. In 1931 for his dissertation on ''Chemical and Physiological Investigations on Canine Gastric Secretion," he was awarded a Ph.D. degree in biochemistry. Although his heart was set on taking a medical degree to become a research clinician, the exigencies of the Great Depression led him to postdoctoral fellowships at Yale, first in the Department of Biochemistry for a year in 1931 and



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