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. "Front Matter." Health Effects of Exposure to Radon: BEIR VI. Washington, DC: The National Academies Press, 1999.
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Extrapolation from Higher to Lower Exposure Rates
32
Interactions of Radon Progeny with Other Agents
Susceptibility
33
Links Between Biologic Evidence and Risk Models
Signatures of Radon Effects
Overview of Committee Risk Assessment
34
2
The Mechanistic Basis of Radon-Induced Lung-Cancer
36
Introduction
Radiation and Oncogenes
38
Tumor-Suppressor Genes
39
Genomic Instability
40
Individual and Genetic Susceptibility
41
Cell-Cycle Effects
44
Apoptosis
45
Radiation-Induced Perturbations of Cellular Proliferation
Cells at Risk
46
Target Size
48
The Special Nature of Biologic Damage Induced by Alpha Particles
49
Biologic Effects of Low Exposure Levels to Alpha Particles
56
Biologic Effects of Alpha Particles at Low Exposure Rates
58
Interactions Between Lung Carcinogens
62
The Dosimetric Approach to Radon Risk Estimation
63
Mechanistic Considerations in Assessing Risks Associated with Radon
64
Biologically-Based Risk Models
Extrapolation From High to Low Radon-Progeny Exposures
65
Effect of Changing Exposure Rate
67
Interaction of Radon Progeny with Other Agents
Biologic Signatures of Alpha-Particle Cancers
68
Individual Susceptibility
3
Models and Risk Projections
69
Risk-Estimation Approaches
70
Dosimetric Approach
Biologically Motivated Approach
Empirical Approach
71
Rationale for the Committee's Chosen Method for Radon Risk Estimation
72
Previous Models
74
BEIR VI Risk Model for Lung-Cancer in Miners
76
Sources of Data
