Analysis of Pooled Data from Different Studies

 

78

   

Model Based on Full Data Set

 

80

   

Model Based on Exposure-Restricted Data

 

81

   

Coherence of Evidence from Miners and from the General Population

 

84

   

BEIR VI Risk Assessment for Lung-Cancer in the General Population

 

85

   

Introduction

 

85

   

Measures of Risk

 

91

   

Relative-Risk Estimates

 

92

   

Population-Risk Estimates

 

93

   

Sources of Uncertainty

 

100

   

Uncertainties in Parameter Estimates Derived from Underground-Miner Data

 

101

   

Uncertainties in Specification of the Lung-Cancer Exposure-Response Model and Its Application to Residential Exposure of the General U.S. Population

 

103

   

Uncertainty Analysis

 

104

   

Comparisons with BEIR IV

 

110

   

BEIR IV and BEIR VI Risk Models

 

110

   

Summary and Conclusions

 

113

4

 

Health Effects of Radon Progeny on Non-Lung-Cancer Outcomes

 

117

   

Doses to Organs Other Than Lung

 

118

   

Nonmalignant Respiratory Diseases

 

119

   

Malignancies Other Than Lung-Cancer

 

120

   

Studies of Underground Miners

 

121

   

Studies of the General Population

 

124

   

Reproductive Outcomes

 

127

   

Conclusions

 

127

 

 

Appendixes

 

 

A

 

Risk Modeling and Uncertainty Analysis

 

129

B

 

Comparative Dosimetry

 

176

C

 

Tobacco-Smoking and Its Interaction with Radon

 

224

D

 

Miner Studies

 

254

E

 

Exposures of Miners to Radon Progeny

 

291

   

Annex 1: Exposures to Miner Cohorts: Review of Estimates for the Studies

 

306

   

Annex 2: Workshop on Uncertainty in Estimating Exposures to Radon Progeny in Studies of Underground Miners

 

331



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