Cover Image


View/Hide Left Panel

Using committee assumptions of time and costs until licensure, the fixed cost of vaccine development has been amortized and is $11 million for a Chlamydia vaccine.

If a vaccine program were implemented today and the vaccine were 100% efficacious and utilized by 100% of the target population, the annualized present value of the cost per QALY gained is -$350. A negative value represents a saving in costs in addition to a saving in QALYs. Using committee assumptions of less-than-ideal utilization and including time and monetary costs until a vaccine program is implemented, the annualized present value of the cost per QALY gained is $200.

See Chapters 4 and 5 for details on the methods and assumptions used by the committee for the results reported.


Alexander LL, Treiman K, Clarke P. A National Survey of Nurse Practitioner Chlamydia Knowledge and Treatment Practices of Female Patients. Nurse Practitioner 1996; 21:48, 51–4.

CDC. Ectopic Pregnancy—United States, 1990–1992. Morbidity and Mortality Weekly Report 1995; 44:46–48.

CDC. Evaluation of Surveillance for Chlamydia trachomatis Infections in the United States, 1987 to 1991. Morbidity and Mortality Weekly Report 1993; 42:21–27.

CDC. Recommendations for the Prevention and Management of Chlamydia trachomatis Infections. Morbidity and Mortality Weekly Report 1993; 42:1–4.

Institute of Medicine. The Hidden Epidemic: Confronting Sexually Transmitted Diseases. Eng TR, Butler WT (eds.). Washington, DC: National Academy Press, 1997.

Jones RB. Chlamydia trachomatis (trachoma perinatal infections, lymphogranuloma vernereum, and other genital infections). In: Principles and Practice of Infectious Diseases. GL Mandell,, JE Bennett, Dolin R eds. New York, NY: Churchill Livingstone, 1995, pp. 1679–1693.

Magid D, Douglas JM, Schwartz JS. Doxycycline Compared with Azithromycin for Treating Women with Genital Chlamydia trachomatis Infections: An Incremental Cost-Effectiveness Analysis. Annals of Internal Medicine 1996; 124:389–99.

U.S. Bureau of the Census. Statistical Abstract of the U.S.: 1995 (115th edition). Washington, DC, 1995.

Ventura SJ, Martin JA, Mathews TJ, et al. Advance Report of Final Natality Statistics, 1994. Monthly Vital Statistics Report 1996; 44.

The National Academies | 500 Fifth St. N.W. | Washington, D.C. 20001
Copyright © National Academy of Sciences. All rights reserved.
Terms of Use and Privacy Statement