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Vaccines for the 21st Century: A Tool for Decisionmaking (2000)
Institute of Medicine (IOM)

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. "Appendix 3: Coccidioides Immitis." Vaccines for the 21st Century: A Tool for Decisionmaking. Washington, DC: The National Academies Press, 2000.

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Vaccines for the 21st Century: A Tool for Decisionmaking

Using committee assumptions of time and costs until licensure, the fixed cost of vaccine development has been amortized and is $10.8 million for a C. immitis vaccine.

If a vaccine program were implemented today and the vaccine were 100% efficacious and utilized by 100% of the target population, the annualized present value of the cost per QALY gained is $85,000. Using committee assumptions of less-than-ideal utilization and including time and monetary costs until a vaccine program is implemented, the annualized present value of the cost per QALY gained is $240,000.

See Chapters 4 and 5 for details on the methods and assumptions used by the committee for the results reported.

READING LIST

Byerly E, Deardorff K. National and State Population Estimates: 1990 to 1994, U.S. Bureau of the Census, Current Population Reports, pp. 25–1127, U.S. Government Printing Office, Washington, DC, 1995.


California Department of Finance. Population of California Counties and the State and Components of Change [WWW document]. URL http://library.ca.gov/california/4e2tabl.html (accessed January 24, 1997).

CDC. Compressed Mortality Database. WONDER (wonder.cdc.gov). 1997. ICD-9, Number 114.


Dugger KO, Villareal KM, et al. Cloning and Sequence Analysis of the cDNA for a Protein from C.immitis with Immunogenic Potential. Biochemical and Biophysical Research Communications 1996; 218:485.


Galgiani JN, Catanzaro A, Cloud GA, et al. Fluconazole Therapy for Coccidioidal meningitis—The NIAID—Mycoses Study Group. Annals of Internal Medicine 1993; 19:28–35.


Hansen KA. Geographical Mobility: March 1993 to March 1994, U.S. Bureau of the Census, Current Population Reports, pp. 20–485, U.S. Government Printing Office, Washington, DC, 1995.


Kirkland TN, Fierer J. Coccidioidomycosis: a Reemerging Infectious Disease. Emerging Infectious Diseases 1996; 2:192–9.


Libke RD, Granoff DM. Coccidioidomycosis. In: Textbook of Pediatric Infectious Diseases. RD Feigin and JD Cherry eds. Philadelphia, PA: WB Saunder Company, 1992, pp. 1916–1928.


Pappagianis D. Evaluation of the Protective Efficacy of the Killed C.immitis Spherule Vaccine in Humans. American Review of Respiratory Disease 1993; 148:656–660.

Pappagianis D. Marked Increase in Cases of Coccidioidomycosis in California: 1991, 1992, and 1993. Clinical Infectious Diseases 1994; 19(Suppl 1):S14–8.


Stevens DA. C.immitis. In: Principles and Practice of Infectious Diseases. GL Mandell, JE Bennett, R Dolin, eds. New York, NY: Churchill Livingstone, 1995, pp. 2365–2374.


Texas Agricultural Experiment Station, Department of Rural Sociology. 1994 Total Population Estimates for Texas Counties [WWW document]. URL http://www-txsdc.tamu.edu/txpop94.html (accessed February 13, 1997).

Texas Department of Health. Bureau of Vital Statistics Annual Report 1994.

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164
Front Matter (R1-R12)
Executive Summary (1-10)
Introduction (11-16)
Progress in Vaccine Development (17-38)
Considerations of Candidate Vaccines (39-52)
Overview of Analytic Approach and Results (53-92)
Review of the Analytical Model (93-108)
Ethical Considerations and Caveats (109-122)
Observations (123-132)
References (133-142)
Appendix 1: Borrelia burgdorferi (143-148)
Appendix 2: Chlamydia (149-158)
Appendix 3: Coccidioides Immitis (159-164)
Appendix 4: Cytomegalovirus (165-172)
Appendix 5: Enterotoxigenic E. coli (173-176)
Appendix 6: Epstein-Barr Virus (177-180)
Appendix 7: Helicobacter pylori (181-188)
Appendix 8: Hepatitis C (189-194)
Appendix 9: Herpes Simplex Virus (195-206)
Appendix 10: Histoplasma capsulatum (207-212)
Appendix 11: Human Paillomavirus (213-222)
Appendix 12: Influenza A and B (223-232)
Appendix 13: Insulin-Dependent Diabetes Mellitus (233-238)
Appendix 14: Melanoma (239-244)
Appendix 15: Multiple Sclerosis (245-250)
Appendix 16: Mycobacterium tuberculosis (251-256)
Appendix 17: Neisseria gonnorrhea (257-266)
Appendix 18: Neisseria meningitidis (267-272)
Appendix 19: Parainfluenza Virus (273-278)
Appendix 20: Respiratory Syncytial Virus (279-284)
Appendix 21: Rheumatoid Arthritis (285-290)
Appendix 22: Rotavirus (291-294)
Appendix 23: Shigella (295-298)
Appendix 24: Streptococcus, Group A (299-304)
Appendix 25: Streptococcus, Group B (305-312)
Appendix 26: Streptococcus pneumoniae (313-322)
Appendix 27: Information on accessing Electronic Spreadsheets (323-324)
Appendix 28: Summary of Workshops (325-434)
Appendix 29: Questions Posed to Outside Experts and List of Responders (435-442)
Index (443-460)