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Using committee assumptions of time and costs until licensure, the fixed cost of vaccine development has been amortized and is $10.8 million for a C. immitis vaccine.

If a vaccine program were implemented today and the vaccine were 100% efficacious and utilized by 100% of the target population, the annualized present value of the cost per QALY gained is $85,000. Using committee assumptions of less-than-ideal utilization and including time and monetary costs until a vaccine program is implemented, the annualized present value of the cost per QALY gained is $240,000.

See Chapters 4 and 5 for details on the methods and assumptions used by the committee for the results reported.

READING LIST

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CDC. Compressed Mortality Database. WONDER (wonder.cdc.gov). 1997. ICD-9, Number 114.


Dugger KO, Villareal KM, et al. Cloning and Sequence Analysis of the cDNA for a Protein from C.immitis with Immunogenic Potential. Biochemical and Biophysical Research Communications 1996; 218:485.


Galgiani JN, Catanzaro A, Cloud GA, et al. Fluconazole Therapy for Coccidioidal meningitis—The NIAID—Mycoses Study Group. Annals of Internal Medicine 1993; 19:28–35.


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Pappagianis D. Marked Increase in Cases of Coccidioidomycosis in California: 1991, 1992, and 1993. Clinical Infectious Diseases 1994; 19(Suppl 1):S14–8.


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Texas Agricultural Experiment Station, Department of Rural Sociology. 1994 Total Population Estimates for Texas Counties [WWW document]. URL http://www-txsdc.tamu.edu/txpop94.html (accessed February 13, 1997).

Texas Department of Health. Bureau of Vital Statistics Annual Report 1994.



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