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Table A8–1 Disease Scenarios for Hepatitis C Infection

 

No. of Cases

% of Cases

Committee HUI Values

Duration (years)

Total Cases (new symptomatic and asymptomatic infections)

150,000

 

Acute Hepatitis

45,000

30%

 

jaundice, malaise, etc.

 

0.90

0.0384 (2 weeks)

Chronic Hepatitis: Slow course—No complications

75,600

50%

 

low-grade symptoms

 

0.97

20.3164 (quality-adjusted life expectancy at onset). 43.3484 (unadjusted life expectancy at onset)

Chronic Hepatitis: Slow course—Cirrhosis to liver failure

3,780

3%

 

low-grade symptoms

 

0.97

20.0000

symptomatic phase

 

0.90

4.0000

terminal cirrhosis; liver failure

 

0.59

1.0000

premature death

 

0.00

12.3902 (quality-adjusted life expectancy at onset+25 years). 21.3870 (unadjusted life expectancy at onset+25 years)

Chronic Hepatitis: Slow course—Cirrhosis to carcinoma

15,120

10%

 

low-grade symptoms

 

0.97

30.0000

symptomatic phase

 

0.90

4.0000

terminal carcinoma

 

0.59

1.0000

premature death

 

0.00

8.7664 (quality-adjusted life expectancy at onset +35 years). 14.4048 (unadjusted life expectancy at onset+35 years)

Chronic Hepatitis: Rapid, progressive course

10,500

7%

 

liver failure: symptomatic

 

0.90

6.0000

liver failure: terminal

 

0.59

1.0000

premature death

 

0.00

18.5549 (quality-adjusted life expectancy at onset+7 years). 36.8422 (unadjusted life expectancy at onset+7 years)



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