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Vaccines for the 21st Century: A Tool for Decisionmaking (2000)
Institute of Medicine (IOM)

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. "Appendix 8: Hepatitis C." Vaccines for the 21st Century: A Tool for Decisionmaking. Washington, DC: The National Academies Press, 2000.

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Vaccines for the 21st Century: A Tool for Decisionmaking

Table A8–2 Health Care Costs Associated with Hepatitis C Infection

 

Duration (years)

% with Care

Cost per Unit

Units per Case

Form of Treatment (per year for chronic phases)

Acute Hepatitis

 

 

0.0384

20%

$50

2.0

physician a

0.0384

5%

$2,000

1.0

hospitalization

0.0384

5%

$100

2.0

physician b

0.0384

5%

$100

2.0

diagnostics b

0.0384

5%

$150

1.0

medication c

Chronic Hepatitis: Slow course—No complications

 

low-grade symptoms

43.3484

10%

$50

1.0

physician a

Chronic Hepatitis: Slow course—Cirrhosis to liver failure

 

low-grade symptoms

20.0000

10%

$100

0.5

physician visit

symptomatic phase

4.0000

100%

$100

4.0

physician b

 

4.0000

10%

$12,000

0.25

biopsy (1 in 4 years)

4.0000

100%

$5,000

0.5

hospitalization (1 in 2 years)

terminal cirrhosis; liver failure

1.0000

100%

$5,000

1.0

hospitalization

 

1.0000

100%

$100

12.0

physician b

Chronic Hepatitis: Slow course—Cirrhosis to carcinoma

 

low-grade symptoms

30.0000

10%

$100

0.5

physician a

symptomatic phase

4.0000

10%

$12,000

0.25

biopsy

 

4.0000

100%

$100

4.0

physician b

4.0000

100%

$5,000

0.5

hospitalization

terminal carcinoma

1.0000

100%

$5,000

1.0

hospitalization

 

1.0000

100%

$100

12.0

physician b

Chronic Hepatitis: Rapid, progressive course

 

liver failure: symptomatic

6.0000

100%

$150

12.0

medication c

 

6.0000

100%

$100

6.0

physician b

6.0000

100%

$1,000

2.0

diagnostics

6.0000

100%

$12,000

0.2

hospitalization

liver failure: terminal

1.0000

100%

$5,000

1.0

hospitalization

 

1.0000

100%

$100

12.0

physician b

Page
192
Front Matter (R1-R12)
Executive Summary (1-10)
Introduction (11-16)
Progress in Vaccine Development (17-38)
Considerations of Candidate Vaccines (39-52)
Overview of Analytic Approach and Results (53-92)
Review of the Analytical Model (93-108)
Ethical Considerations and Caveats (109-122)
Observations (123-132)
References (133-142)
Appendix 1: Borrelia burgdorferi (143-148)
Appendix 2: Chlamydia (149-158)
Appendix 3: Coccidioides Immitis (159-164)
Appendix 4: Cytomegalovirus (165-172)
Appendix 5: Enterotoxigenic E. coli (173-176)
Appendix 6: Epstein-Barr Virus (177-180)
Appendix 7: Helicobacter pylori (181-188)
Appendix 8: Hepatitis C (189-194)
Appendix 9: Herpes Simplex Virus (195-206)
Appendix 10: Histoplasma capsulatum (207-212)
Appendix 11: Human Paillomavirus (213-222)
Appendix 12: Influenza A and B (223-232)
Appendix 13: Insulin-Dependent Diabetes Mellitus (233-238)
Appendix 14: Melanoma (239-244)
Appendix 15: Multiple Sclerosis (245-250)
Appendix 16: Mycobacterium tuberculosis (251-256)
Appendix 17: Neisseria gonnorrhea (257-266)
Appendix 18: Neisseria meningitidis (267-272)
Appendix 19: Parainfluenza Virus (273-278)
Appendix 20: Respiratory Syncytial Virus (279-284)
Appendix 21: Rheumatoid Arthritis (285-290)
Appendix 22: Rotavirus (291-294)
Appendix 23: Shigella (295-298)
Appendix 24: Streptococcus, Group A (299-304)
Appendix 25: Streptococcus, Group B (305-312)
Appendix 26: Streptococcus pneumoniae (313-322)
Appendix 27: Information on accessing Electronic Spreadsheets (323-324)
Appendix 28: Summary of Workshops (325-434)
Appendix 29: Questions Posed to Outside Experts and List of Responders (435-442)
Index (443-460)