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Table A10–1 Incidence and Mortality Rates for Histoplasma Infection

Age Groups

Population

Incidence Rates (per 100,000)

% Distribution of Cases

<1

3,963,000

79.28

0.0063

1–4

16,219,000

79.28

0.0257

5–14

38,056,000

105.11

0.0800

15–24

36,263,000

348.84

0.2530

25–34

41,670,000

325.17

0.2710

35–44

42,149,000

161.33

0.1360

45–54

30,224,000

163.78

0.0990

55–64

21,241,000

174.19

0.0740

65–74

18,964,000

102.83

0.0390

75–84

11,088,000

54.47

0.0121

85+

3,598,000

54.47

0.0039

Total

263,435,000

189.80

1.000

 

500,000 cases

 

Age Groups

Population

Mortality Rates (per 100,000)

% Distribution of Deaths

<1

3,963,000

0.04

0.0114

1–4

16,219,000

0.01

0.0093

5–14

38,056,000

0.01

0.0290

15–24

36,263,000

0.03

0.0918

25–34

41,670,000

0.03

0.0983

35–44

42,149,000

0.08

0.2467

45–54

30,224,000

0.08

0.1796

55–64

21,241,000

0.09

0.1342

65–74

18,964,000

0.10

0.1415

75–84

11,088,000

0.05

0.0438

85+

3,598,000

0.05

0.0142

Total

263,435,000

0.05

1.0000

 

138 deaths

 

Disease Scenarios

For the purposes of the calculation in this report, the committee assumed that most infections are asymptomatic. Half of symptomatic infections were presumed to be associated with a mild flu-like illness. Other manifestations include pneumonitis, disseminated disease, and chronic pulmonary disease. Outpatient treatment of pneumonitis was associated with both inpatient and outpatient treatment. Disseminated histoplasma was associated with an acute and severe phase of illness followed by a more moderate but lengthy recovery. Health utility indexes associated with histoplasma disease range from .9 for a mild flu-like illness to .39 for the acute illness associated with disseminated disease. Table A10–2 shows the HUI and duration associated with the disease scenarios used in the calculations for the report.



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