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If a vaccine program for IDDM were implemented today and the vaccine was 100% efficacious and utilized by 100% of the target population, the annualized present value of the health care costs saved would be $2.5 billion. Using committee assumptions of less-than-ideal efficacy and utilization and including time and monetary costs until a vaccine program is implemented, the annualized present value of the health care costs saved would be $550 million.

If a vaccine program for IDDM were implemented today and the vaccine was 100% efficacious and utilized by 100% of the target population, the annualized present value of the program cost would be $45 million. Using committee assumptions of less-than-ideal efficacy and utilization and including time and monetary costs until a vaccine program is implemented, the annualized present value of the program cost would be $25 million.

Using committee assumptions of time and costs until licensure, the fixed cost of vaccine development has been amortized and is $10.8 million for an IDDM vaccine.

If a vaccine program were implemented today and the vaccine were 100% efficacious and utilized by 100% of the target population, the annualized present value of the cost per QALY gained is -$14,500. A negative value represents a saving in costs in addition to a saving in QALYs. Using committee assumptions of less-than-ideal utilization and including time and monetary costs until a vaccine program is implemented, the annualized present value of the cost per QALY gained is -$13,500.

See Chapters 4 and 5 for details on the methods and assumptions used by the committee for the results reported.

READING LIST

DERI Mortality Study Group. International Analysis of Insulin-Dependent Diabetes Mellitus Mortality: A Preventable Mortality Perspective. American Journal of Epidemiology 1995; 142:612–618.


Gorham ED, Garland FC, Barrett-Connor E, et al. Incidence of Insulin-Dependent Diabetes Mellitus in Young Adults: Experience of 1,587,630 US Navy Enlisted Personnel. American Journal of Epidemiology 1993; 138:984–987.


Metcalfe MA, Baum JD. Incidence of Insulin-Dependent Diabetes in Children Aged Under 15 years in the British Isles During 1988. BMJ 1991; 302:443–447.

Mølbak AG, Christau B, Marner B, et al. Incidence of Insulin-Dependent Diabetes Mellitus in Age Groups Over 30 years in Denmark. Diabetic Medicine 1994; 11:650–655.


National Institute of Diabetes and Digestive and Kidney Diseases. Diabetes Statistics [WWW document]. URL http://www.niddk.nih.gov/index.htm (accessed September 23, 1996).


Schoenle EJ, Molinari L, Bagot M, et al. Epidemiology of IDDM in Switzerland. Diabetes Care 1994; 17:955–960.



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