Vaccines for the 21st Century: A Tool for Decisionmaking

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Vaccines for the 21st Century: A Tool for Decisionmaking (2000)
Institute of Medicine (IOM)

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. "Appendix 17: Neisseria gonnorrhea." Vaccines for the 21st Century: A Tool for Decisionmaking. Washington, DC: The National Academies Press, 2000.

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Vaccines for the 21st Century: A Tool for Decisionmaking

Table A17–1 Incidence of N.gonorrhea Infection in Women and Men

Age Groups	Female Population	Incidence Rates (per 100,000)	% Distribution of Cases	Cases
<1	1,933,000	0.00	0.0000	0
1–4	7,905,000	29.10	0.0050	2,300
5–14	18,554,000	111.57	0.0450	20,700
15–24	17,747,000	1,555.19	0.6000	276,000
25–34	20,835,000	662.35	0.3000	138,000
35–44	21,238,000	75.81	0.0350	16,100
45–54	15,447,000	29.78	0.0100	4,600
55–64	11,140,000	20.65	0.0050	2,300
65–74	10,544,000	0.00	0.0000	0
75–84	6,814,000	0.00	0.0000	0
85+	2,593,000	0.00	0.0000	0
Total	134,750,000	341.37	1.0000	460,000
Age Groups	Male Population	Incidence Rates (per 100,000)	% Distribution of Cases	Cases
<1	2,030,000	0.00	0.0000	0
1–4	8,314,000	32.48	0.0050	2,700
5–14	19,502,000	124.60	0.0450	24,300
15–24	18,516,000	1,749.84	0.6000	324,000
25–34	20,835,000	777.54	0.3000	162,000
35–44	20,911,000	90.38	0.0350	18,900
45–54	14,777,000	36.54	0.0100	5,400
55–64	10,101,000	26.73	0.0050	2,700
65–74	8,420,000	0.00	0.0000	0
75–84	4,274,000	0.00	0.0000	0
85+	1,005,000	0.00	0.0000	0
Total	128,685,000	419.63	1.0000	540,000

For the purposes of the calculations in this report, the committee assumed that 15% of cases in men are asymptomatic and untreated. The overwhelming utility index and length of time spent in the health state range from .85 HUI for 7 days (cervicitis) to .46 HUI for 2 days (surgery for PID) to .6 HUI for more than 20 years (chronic pelvic pain).

For the purposes of the calculations in this report, the committee assumed that 15% of cases in men are asymptomatic and untreated. The overwhelming proportion of symptomatic cases involve urethritis, which was assumed to be associated with an HUI of .84 and 7 days duration. A small percentage of men infected with gonorrhea experience epididymitis. The HUI and length of time spent in the health state for these manifestations range from .84 HUI for 7 days (urethritis) to .3 HUI for 3 days (hospitalization for epididymitis).

A small fraction of both men and women infected with gonorrhea experience disseminated infections. Hospitalization for these patients is associated with an HUI of .52 for 4 days; outpatient treatment is associated with a week of a higher HUI state. See Table A17–2 for a summary of the disease states associated with gonorrhea infections.