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Table A18–2 Disease Scenarios for Neisseria meningitidis B Infection

 

No. of Cases

% of Cases

Committee HUI Values

Duration (years)

MENINGITIS

780

65.00%

 

Meningitis (ICU)

624

52.00%

 

ICU

 

0.24

0.0055 (2 days)

inpatient after ICU

 

0.28

0.0137 (5 days)

Meningitis (no ICU)

156

13.00%

 

inpatient

 

0.39

0.0137 (5 days)

Meningitis—complications

117

9.75%

 

acute complications (gangrene, arthritis, heart failure, etc.)

 

0.27

0.0274 (10 days)

Meningitis—sequelae

39

3.25%

 

neurologic sequelae (cranial nerve damage, deafness, etc.)

 

0.60

23.2209 (discounted quality adjusted life expectancy at average age at onset) (average age at onset=18.3)

BACTEREMIA/SEPSIS

420

35.00%

 

Bacteremia/Sepsis

210

17.50%

 

ICU (Waterhouse Friederichsen)

 

0.16

0.0110 (4 days)

inpatient after ICU

 

0.44

0.0274 (10 days)

Bacteremia/Sepsis (hospitalization; no ICU)

210

17.50%

0.71

0.0137 (5 days)

Bacteremia/Sepsis—complications

63

5.25%

0.59

0.0274 (10 days)

acute complications (cardiac, DIC, pneumonia, etc.)

 

Bacteremia/Sepsis—sequelae

13

1.05%

0.63

23.2209 (discounted quality adjusted life expectancy at age 18) (average age at onset)

COST INCURRED BY DISEASE

Table A18–3 summarizes the health care costs incurred by NMB infections. For the purposes of the calculations in this report, it was assumed that patients with meningitis incur costs associated with hospitalization (hospital costs, specialist physicians, diagnostics). Patients who experience complications incur additional hospitalization costs. The small percentage of patients who



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