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Vaccines for the 21st Century: A Tool for Decisionmaking (2000)
Institute of Medicine (IOM)

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. "Appendix 19: Parainfluenza Virus." Vaccines for the 21st Century: A Tool for Decisionmaking. Washington, DC: The National Academies Press, 2000.

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Vaccines for the 21st Century: A Tool for Decisionmaking

Table A19–1 Disease Scenarios for Parainfluenza Virus Infection

 

% of Cases

Committee HUI Values

Duration (years)

Upper Respiratory

70.00%

 

pharyngitis, otitis media

 

0.90

0.0192 (7 days)

Croup

19.20%

 

outpatient only

 

0.75

0.0274 (10 days)

Croup

0.80%

 

inpatient

 

0.50

0.0192 (7 days)

outpatient

 

0.75

0.0082 (3 days)

Bronchiolitis/pneumonia

9.60%

 

outpatient only

 

0.75

0.0274 (10 days)

Bronchiolitis/pneumonia

0.40%

 

inpatient

 

0.50

0.0192 (7 days)

outpatient

 

0.75

0.0082 (3 days)

Upper Respiratory

90.00%

0.90

0.0192 (7 days)

Bronchiolitis/pneumonia

10.00%

0.75

0.0274 (10 days)

Upper Respiratory

90.00%

0.90

0.0192 (7 days)

Bronchiolitis/pneumonia

9.60%

0.75

0.0274 (10 days)

Bronchiolitis/pneumonia

0.40%

 

inpatient

 

0.50

0.0192 (7 days)

outpatient

 

0.75

0.0082 (3 days)

COST INCURRED BY DISEASE

Table A19–2 summarizes the health care costs incurred by PIV infections. For the purposes of the calculations in this report, it was assumed that all children 2 years of age and under with PIV disease receive medical treatment. It was assumed that only 50% of people between the ages of 2 and 64 receive treatment for PIV disease. It was also assumed that only 50% of people 65 years of age and older receive treatment for mild (requiring only outpatient treatment if treated) pharyngitis and bronchiolitis. A small number of people age 65 years of age and older are hospitalized for bronchiolitis and pneumonia.

Pharyngitis, otitis media, croup, and outpatient treatment of bronchiolitis/pneumonia were assumed to be associated with physician visits, diagnostics and medications. The more serious disease incurred more visits to the physician. Hospitalization costs are included for the small number of people with PIV disease who require it.

Page
274
Front Matter (R1-R12)
Executive Summary (1-10)
Introduction (11-16)
Progress in Vaccine Development (17-38)
Considerations of Candidate Vaccines (39-52)
Overview of Analytic Approach and Results (53-92)
Review of the Analytical Model (93-108)
Ethical Considerations and Caveats (109-122)
Observations (123-132)
References (133-142)
Appendix 1: Borrelia burgdorferi (143-148)
Appendix 2: Chlamydia (149-158)
Appendix 3: Coccidioides Immitis (159-164)
Appendix 4: Cytomegalovirus (165-172)
Appendix 5: Enterotoxigenic E. coli (173-176)
Appendix 6: Epstein-Barr Virus (177-180)
Appendix 7: Helicobacter pylori (181-188)
Appendix 8: Hepatitis C (189-194)
Appendix 9: Herpes Simplex Virus (195-206)
Appendix 10: Histoplasma capsulatum (207-212)
Appendix 11: Human Paillomavirus (213-222)
Appendix 12: Influenza A and B (223-232)
Appendix 13: Insulin-Dependent Diabetes Mellitus (233-238)
Appendix 14: Melanoma (239-244)
Appendix 15: Multiple Sclerosis (245-250)
Appendix 16: Mycobacterium tuberculosis (251-256)
Appendix 17: Neisseria gonnorrhea (257-266)
Appendix 18: Neisseria meningitidis (267-272)
Appendix 19: Parainfluenza Virus (273-278)
Appendix 20: Respiratory Syncytial Virus (279-284)
Appendix 21: Rheumatoid Arthritis (285-290)
Appendix 22: Rotavirus (291-294)
Appendix 23: Shigella (295-298)
Appendix 24: Streptococcus, Group A (299-304)
Appendix 25: Streptococcus, Group B (305-312)
Appendix 26: Streptococcus pneumoniae (313-322)
Appendix 27: Information on accessing Electronic Spreadsheets (323-324)
Appendix 28: Summary of Workshops (325-434)
Appendix 29: Questions Posed to Outside Experts and List of Responders (435-442)
Index (443-460)