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alized present value of the QALYs gained would be 27,000. Using committee assumptions of less-than-ideal efficacy and utilization and including time and monetary costs until a vaccine program is implemented, the annualized present value of the QALYs gained would be 14,000.

If a vaccine program for rotavirus were implemented today and the vaccine was 100% efficacious and utilized by 100% of the target population, the annualized present value of the health care costs saved would be $225 million. Using committee assumptions of less-than-ideal efficacy and utilization and including time and monetary costs until a vaccine program is implemented, the annualized present value of the health care costs saved would be $120 million.

If a vaccine program for rotavirus were implemented today and the vaccine was 100% efficacious and utilized by 100% of the target population, the annualized present value of the program cost would be $720 million. Using committee assumptions of less-than-ideal efficacy and utilization and including time and monetary costs until a vaccine program is implemented, the annualized present value of the program cost would be $510 million.

Using committee assumptions of time and costs until licensure, the fixed cost of vaccine development has been amortized and is $3.6 million for a rotavirus vaccine.

If a vaccine program were implemented today and the vaccine was 100% efficacious and utilized by 100% of the target population, the annualized present value of the cost per QALY gained is $20,000. Using committee assumptions of less-than-ideal utilization and including time and monetary costs until a vaccine program is implemented, the annualized present value of the cost per QALY gained is $30,000.

See Chapters 4 and 5 for details on the methods and assumptions used by the committee for the results reported.

During the time the data for this report was being analyzed and written, a rotavirus vaccine was licensed. The calculated cost per QALY saved for a vaccine strategy for a currently licensed rotavirus vaccine (assuming 75% effectiveness and 90% utilization and all other disease burden and costs as described above) decreases slightly to approximately $26,500.

READING LIST

Glass RI, Kilgore PE, Holman RC, et al. The Epidemiology of Rotavirus Diarrhea in the United States: Surveillance and Estimates of Disease Burden. The Journal of Infectious Diseases 1996; 174:S5–11.


Matson DO. Potential Impact of Rotavirus Vaccines. URL http://rotavirus.com/potential_impact_of_rota.html (accessed August 8, 1996).


Offit PA, Clark HF. Rotavirus. In: Principles and Practice of Infectious Diseases. GL Mandell, JE Bennett, Dolin R eds. New York, NY: Churchill Livingstone, 1995, pp. 1448–1455.



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