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Vaccines for the 21st Century: A Tool for Decisionmaking (2000)
Institute of Medicine (IOM)

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. "Appendix 25: Streptococcus, Group B." Vaccines for the 21st Century: A Tool for Decisionmaking. Washington, DC: The National Academies Press, 2000.

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Vaccines for the 21st Century: A Tool for Decisionmaking

 

% with Care

Cost per Unit

Units per Case

Form of Treatment

 

100%

$500

1.0

diagnostic c

permanent impairment normal lifespan*

100%

$225

365.0

long-term care*/per year

Meningitis with early death

 

acute care

50%

$12,000

1.0

hospitalization NICU

 

50%

$7,000

1.0

hospitalization NICU

50%

$150

10.0

physician c

50%

$500

1.0

diagnostic c

permanent impairment for 10-year period**

100%

$225

365.0

long-term care*/per year

PREGNANT WOMEN

 

Maternal Infection (chorioamnionitis, endometritis, bacteremia)

additional inpatient treatment at time of delivery

100%

$1,000

1.0

hospitalization (in addition to normal delivery)

 

100%

$150

1.0

physician c

100%

$50

1.0

medication b

outpatient treatment

100%

$100

1.0

physician b

screening

90%

$50

1.0

diagnostic a

intrapartum chemoprophylaxis

25%

$50

1.0

medication b

NONPREGNANT ADULTS

 

Invasive disease

 

soft tissue, bone infection bacteremia; urosepsis; pneumonia

100%

$4,000

1.0

hospitalization

 

100%

$150

19.0

physician c

100%

$500

1.0

diagnostic c

outpatient

100%

$100

2.0

physician b

NOTE: *long-term care—$225/day is maintenance expenditure per resident for residential facilities for persons with mental retardation.

**cost per case is calculated as “present value” of annual cost for remaining life time (life expectancy at birth or 10 years, depending on scenario); additional discounting for immunization interval

development of a vaccine for use in pregnant women is discussed within the body of the report. Table 4–1 summarizes vaccine development assumptions for all vaccines considered in this report.

Page
309
Front Matter (R1-R12)
Executive Summary (1-10)
Introduction (11-16)
Progress in Vaccine Development (17-38)
Considerations of Candidate Vaccines (39-52)
Overview of Analytic Approach and Results (53-92)
Review of the Analytical Model (93-108)
Ethical Considerations and Caveats (109-122)
Observations (123-132)
References (133-142)
Appendix 1: Borrelia burgdorferi (143-148)
Appendix 2: Chlamydia (149-158)
Appendix 3: Coccidioides Immitis (159-164)
Appendix 4: Cytomegalovirus (165-172)
Appendix 5: Enterotoxigenic E. coli (173-176)
Appendix 6: Epstein-Barr Virus (177-180)
Appendix 7: Helicobacter pylori (181-188)
Appendix 8: Hepatitis C (189-194)
Appendix 9: Herpes Simplex Virus (195-206)
Appendix 10: Histoplasma capsulatum (207-212)
Appendix 11: Human Paillomavirus (213-222)
Appendix 12: Influenza A and B (223-232)
Appendix 13: Insulin-Dependent Diabetes Mellitus (233-238)
Appendix 14: Melanoma (239-244)
Appendix 15: Multiple Sclerosis (245-250)
Appendix 16: Mycobacterium tuberculosis (251-256)
Appendix 17: Neisseria gonnorrhea (257-266)
Appendix 18: Neisseria meningitidis (267-272)
Appendix 19: Parainfluenza Virus (273-278)
Appendix 20: Respiratory Syncytial Virus (279-284)
Appendix 21: Rheumatoid Arthritis (285-290)
Appendix 22: Rotavirus (291-294)
Appendix 23: Shigella (295-298)
Appendix 24: Streptococcus, Group A (299-304)
Appendix 25: Streptococcus, Group B (305-312)
Appendix 26: Streptococcus pneumoniae (313-322)
Appendix 27: Information on accessing Electronic Spreadsheets (323-324)
Appendix 28: Summary of Workshops (325-434)
Appendix 29: Questions Posed to Outside Experts and List of Responders (435-442)
Index (443-460)