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Vaccines for the 21st Century: A Tool for Decisionmaking (2000)
Institute of Medicine (IOM)

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. "Appendix 26: Streptococcus pneumoniae." Vaccines for the 21st Century: A Tool for Decisionmaking. Washington, DC: The National Academies Press, 2000.

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Vaccines for the 21st Century: A Tool for Decisionmaking

 

No. of Cases

% of Cases

Committee HUI Values

Duration (years)

Bacteremia/Sepsis—inpatient (no ICU)

10,749

1.01%

0.71

0.0110 (4 days)

Bacteremia/Sepsis—inpatient, complications

3,583

0.34%

0.59

0.0137 (5 days)

PNEUMONIA

179,145

16.8840%

 

Pneumonia—outpatient care only

71,658

6.75%

0.82

0.0274 (10 days)

Pneumonia

107,487

10.13%

 

inpatient

 

0.71

0.0137 (5 days)

outpatient after inpatient

 

0.81

0.0137 (5 days)

Pneumonia with emphysema

2,687

0.25%

 

inpatient

 

0.64

0.0384 (14 days)

outpatient after inpatient

 

0.82

0.0384 (14 days)

OTHER RESPIRATORY

861,667

81.2103%

 

Sinusitis, bronchitis

 

0.90

0.0274 (10 days)

MENINGITIS

2,306

0.2173%

 

Meningitis

1,845

0.17%

 

ICU

 

0.24

0.0055 (2 days)

inpatient after ICU

 

0.28

0.0274 (10 days)

Meningitis—inpatient (no ICU)

461

0.04%

0.39

0.0137 (5 days)

Meningitis—inpatient, acute complications

346

0.03%

0.27

0.0384 (14 days)

Meningitis—neurologic sequelae

692

0.07%

0.60

19.8289 (quality adjusted life expectancy at onset); 43.3814 (unadjusted life expectancy at onset)

65 YEARS AND OLDER

 

Total Deaths (from acute infection)

29,592

 

Total Cases

397,808

 

BACTEREMIA/SEPSIS

23,555

5.92%

 

Bacteremia/Sepsis

4,711

1.18%

 

outpatient care only

 

0.93

0.0274 (10 days)

ICU

 

0.16

0.0055 (2 days)

inpatient after ICU

 

0.46

0.0137 (5 days)

Bacteremia/Sepsis

14,133

3.55%

 

inpatient (no ICU)

 

0.71

0.0110 (4 days)

Bacteremia/Sepsis—inpatient; complications

4,711

1.18%

0.59

0.0137 (5 days)

PNEUMONIA

235,550

59.21%

 

Pneumonia—outpatient care only

141,330

35.53%

0.82

0.0274 (10 days)

Page
316
Front Matter (R1-R12)
Executive Summary (1-10)
Introduction (11-16)
Progress in Vaccine Development (17-38)
Considerations of Candidate Vaccines (39-52)
Overview of Analytic Approach and Results (53-92)
Review of the Analytical Model (93-108)
Ethical Considerations and Caveats (109-122)
Observations (123-132)
References (133-142)
Appendix 1: Borrelia burgdorferi (143-148)
Appendix 2: Chlamydia (149-158)
Appendix 3: Coccidioides Immitis (159-164)
Appendix 4: Cytomegalovirus (165-172)
Appendix 5: Enterotoxigenic E. coli (173-176)
Appendix 6: Epstein-Barr Virus (177-180)
Appendix 7: Helicobacter pylori (181-188)
Appendix 8: Hepatitis C (189-194)
Appendix 9: Herpes Simplex Virus (195-206)
Appendix 10: Histoplasma capsulatum (207-212)
Appendix 11: Human Paillomavirus (213-222)
Appendix 12: Influenza A and B (223-232)
Appendix 13: Insulin-Dependent Diabetes Mellitus (233-238)
Appendix 14: Melanoma (239-244)
Appendix 15: Multiple Sclerosis (245-250)
Appendix 16: Mycobacterium tuberculosis (251-256)
Appendix 17: Neisseria gonnorrhea (257-266)
Appendix 18: Neisseria meningitidis (267-272)
Appendix 19: Parainfluenza Virus (273-278)
Appendix 20: Respiratory Syncytial Virus (279-284)
Appendix 21: Rheumatoid Arthritis (285-290)
Appendix 22: Rotavirus (291-294)
Appendix 23: Shigella (295-298)
Appendix 24: Streptococcus, Group A (299-304)
Appendix 25: Streptococcus, Group B (305-312)
Appendix 26: Streptococcus pneumoniae (313-322)
Appendix 27: Information on accessing Electronic Spreadsheets (323-324)
Appendix 28: Summary of Workshops (325-434)
Appendix 29: Questions Posed to Outside Experts and List of Responders (435-442)
Index (443-460)