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Vaccines for the 21st Century: A Tool for Decisionmaking (2000)
Institute of Medicine (IOM)

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Vaccines for the 21st Century: A Tool for Decisionmaking

Biotechnology, 26, 30, 33–34, 90, 379, 381–386

attenuated live viruses, 19, 20, 24–25, 328–329, 352, 379

Epstein-Barr virus, 332–333, 334

hepatitis B virus, 18, 379

hepatitis C virus, 337

herpes simplex virus, 327–328

Histoplasma capsulatum 358

hybridoma, 30

monoclonal antibodies, 29–30

mycobacterium tuberculosis, 355

papillomaviruses, 339–340

risk capital, 125

Salmonella, 31–32

see also DNA; Genomes; RNA

Bordetella pertussis, 11, 18, 19, 20, 28, 30, 46

Borrelia burgdorferi, 7, 44, 54, 88, 91, 100, 143–148

Burkitt’s lymphoma, 330, 331, 332, 333

C

Canada, 49, 62, 66, 68, 96, 99

Cancer, 1, 12, 185, 189, 190, 194, 213–219, 381, 411, 415–433

autoimmune therapy, 427–429, 431

Epstein-Barr virus, 330–333

melanoma, 6, 54, 88, 89–90, 239–243, 421

papillomaviruses, 338–342

Caribbean region, 343

Centers for Disease Control and Prevention, 14, 28, 50, 100, 125, 126

Central nervous system, 67, 399–403

herpes simplex virus, 196–200 (passim), 202, 204, 328

multiple sclerosis, 6, 35, 54, 87, 245–249, 397, 399–400

see also Neisseria meningitidis

Children, 7, 8–9, 45–47, 60, 69, 72, 80–82, 91, 99, 100, 101, 111, 130, 377

American Academy of Pediatrics, 45, 126

CDC recommendations, 28

chlamydia, 6, 88, 157

combination vaccines, 9, 18, 38, 46–47, 75, 130

contraceptive vaccines, health effects, 76

cytomegalovirus, 6, 90, 167

dengue virus, 343, 345

Epstein-Barr virus, 7, 88, 177, 179, 330–331, 333

gonorrhea, 6, 88

Helicobacter pylori, 181

herpes simplex virus, 6, 88, 196, 203, 329

influenza virus, 223–224

liability issues, 128–129

meningitis, 267

National Childhood Vaccine Injury Act, 20–21, 128–129, 258

papillomaviruses, 6, 88, 219, 342

pregnant, 51

polio, 24

record-keeping, 46, 47, 49

respiratory syncytial virus, 88, 279, 280, 281

rotavirus, 291–292

school entry immunizations, 7, 8–9, 20, 49, 90, 130

Shigella, 295

streptococcus, group A, 299, 363

streptococcus, group B, 6, 93, 310, 311–312

Streptococcus pneumoniae 313, 314, 315

Vaccines for Children Program, 47, 131

see also Infants

Children’s Vaccine Initiative, 127–128

China, 334

Chlamydia, 6, 54, 67, 88, 89–90, 97, 149–158, 347–351, 368

Cholera, see Vibrio cholerae

Clinical trials, 9, 19, 70, 105, 126, 406, 417, 424, 430–431, 436

djuvants, 373, 374

AIDS, 373, 379

Bordetella pertussis, 30

Page
445
Front Matter (R1-R12)
Executive Summary (1-10)
Introduction (11-16)
Progress in Vaccine Development (17-38)
Considerations of Candidate Vaccines (39-52)
Overview of Analytic Approach and Results (53-92)
Review of the Analytical Model (93-108)
Ethical Considerations and Caveats (109-122)
Observations (123-132)
References (133-142)
Appendix 1: Borrelia burgdorferi (143-148)
Appendix 2: Chlamydia (149-158)
Appendix 3: Coccidioides Immitis (159-164)
Appendix 4: Cytomegalovirus (165-172)
Appendix 5: Enterotoxigenic E. coli (173-176)
Appendix 6: Epstein-Barr Virus (177-180)
Appendix 7: Helicobacter pylori (181-188)
Appendix 8: Hepatitis C (189-194)
Appendix 9: Herpes Simplex Virus (195-206)
Appendix 10: Histoplasma capsulatum (207-212)
Appendix 11: Human Paillomavirus (213-222)
Appendix 12: Influenza A and B (223-232)
Appendix 13: Insulin-Dependent Diabetes Mellitus (233-238)
Appendix 14: Melanoma (239-244)
Appendix 15: Multiple Sclerosis (245-250)
Appendix 16: Mycobacterium tuberculosis (251-256)
Appendix 17: Neisseria gonnorrhea (257-266)
Appendix 18: Neisseria meningitidis (267-272)
Appendix 19: Parainfluenza Virus (273-278)
Appendix 20: Respiratory Syncytial Virus (279-284)
Appendix 21: Rheumatoid Arthritis (285-290)
Appendix 22: Rotavirus (291-294)
Appendix 23: Shigella (295-298)
Appendix 24: Streptococcus, Group A (299-304)
Appendix 25: Streptococcus, Group B (305-312)
Appendix 26: Streptococcus pneumoniae (313-322)
Appendix 27: Information on accessing Electronic Spreadsheets (323-324)
Appendix 28: Summary of Workshops (325-434)
Appendix 29: Questions Posed to Outside Experts and List of Responders (435-442)
Index (443-460)