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Vaccines for the 21st Century: A Tool for Decisionmaking (2000)
Institute of Medicine (IOM)

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. "Overview of Analytic Approach and Results." Vaccines for the 21st Century: A Tool for Decisionmaking. Washington, DC: The National Academies Press, 2000.

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Vaccines for the 21st Century: A Tool for Decisionmaking

condition, but is delayed 1 or more years beyond the onset of the condition. For example, some infants infected with group B streptococcus at birth survive with neurologic impairment for several years but die by about age 10.

BOX 4–2 HUI-based Quality-adjustment Weight for Ectopic Pregnancy

Attribute

Description

 

Utility Function

 

1. Sensory

1. Able to see, hear, and speak normally for age

1.00

 

 

2. Requires equipment to see or hear or speak

 

0.95

 

 

3. See, hears, or speaks with limitations, even with equipment

 

0.86

 

 

4. Blind, deaf, or mute

 

0.61

 

1. Sensory Total

b1=1.0

2. Mobility

1. Able to walk, bend, lift, jump and run normally for age

 

1.00

 

 

2. Walks, bends, lifts, jumps, or runs with some limitations, but does not require help

 

0.97

 

 

3. Requires mechanical equipment (such as canes, crutches, braces, or wheelchair) to walk or get around independently

 

0.84

 

 

4. Requires the help of another person to walk or get around and requires mechanical equipment as well

0.73

 

 

5. Unable to control or use arms and legs

 

0.58

 

2. Mobility Total

b2=.73

3. Emotion

1. Generally happy and free from worry

 

1.00

 

 

2. Occasionally fretful, angry, irritable, anxious, or depressed (or suffering night terrors—for children)

 

0.93

 

 

3. Often fretful, angry, irritable, anxious, depressed, (or suffering night terrors—for children)

 

0.81

 

 

4. Almost always fretful, angry, irritable, anxious, or depressed

0.70

 

 

5. Extremely fretful, angry, irritable, or depressed, usually requiring hospitalization or psychiatric institutional care

 

0.53

 

3. Emotion Total

b3=.7

4. Cognitive

1. Learns and remembers normally for age (e.g. schoolwork—for children)

 

1.00

 

 

2. Learns and remembers more slowly than normally for age (e.g. schoolwork, for children)

0.95

 

Page
64
Front Matter (R1-R12)
Executive Summary (1-10)
Introduction (11-16)
Progress in Vaccine Development (17-38)
Considerations of Candidate Vaccines (39-52)
Overview of Analytic Approach and Results (53-92)
Review of the Analytical Model (93-108)
Ethical Considerations and Caveats (109-122)
Observations (123-132)
References (133-142)
Appendix 1: Borrelia burgdorferi (143-148)
Appendix 2: Chlamydia (149-158)
Appendix 3: Coccidioides Immitis (159-164)
Appendix 4: Cytomegalovirus (165-172)
Appendix 5: Enterotoxigenic E. coli (173-176)
Appendix 6: Epstein-Barr Virus (177-180)
Appendix 7: Helicobacter pylori (181-188)
Appendix 8: Hepatitis C (189-194)
Appendix 9: Herpes Simplex Virus (195-206)
Appendix 10: Histoplasma capsulatum (207-212)
Appendix 11: Human Paillomavirus (213-222)
Appendix 12: Influenza A and B (223-232)
Appendix 13: Insulin-Dependent Diabetes Mellitus (233-238)
Appendix 14: Melanoma (239-244)
Appendix 15: Multiple Sclerosis (245-250)
Appendix 16: Mycobacterium tuberculosis (251-256)
Appendix 17: Neisseria gonnorrhea (257-266)
Appendix 18: Neisseria meningitidis (267-272)
Appendix 19: Parainfluenza Virus (273-278)
Appendix 20: Respiratory Syncytial Virus (279-284)
Appendix 21: Rheumatoid Arthritis (285-290)
Appendix 22: Rotavirus (291-294)
Appendix 23: Shigella (295-298)
Appendix 24: Streptococcus, Group A (299-304)
Appendix 25: Streptococcus, Group B (305-312)
Appendix 26: Streptococcus pneumoniae (313-322)
Appendix 27: Information on accessing Electronic Spreadsheets (323-324)
Appendix 28: Summary of Workshops (325-434)
Appendix 29: Questions Posed to Outside Experts and List of Responders (435-442)
Index (443-460)