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Cost per QALY gained with vaccine

 

a.

Immediately available vaccine (100% efficacy and use, no development cost or time)

$89,660

b.

Immediately available vaccine with likely effect and use (no development cost or time)

$123,816

c.

Vaccine available with addition of development cost and time

$125,980

 

QALYs to Be Gained

Net Cost

Cost of Care Saved

Delivery Costs

Development Costs

a.

Baseline

 

Immediately available vaccine (100% efficacy and use, no development cost or time)

7,026.64

$630,009,848

$89,990,152

$720,000,000

$240,000,000

b.

Adjustments for Vaccine Efficacy and Utilization

 

Anticipated vaccine efficacy: 75%

5,269.98

 

$67,492,614

N/A

N/A

 

Anticipated vaccine utilization: 90%

4,742.98

$587,256,647

$60,743,353

$648,000,000

N/A

c.

Adjustment for Vaccine Development Costs and Time

 

Vaccine available with addition of development cost and time

3,326.63b

$419,089,997

$42,604, 166b

$454,494,162b

$7,200,000c

aNot applicable for Vaccine X-1; relevant for other Vaccine X examples.

bAnnualize present value=(adjusted baseline)/(l+r)Tuse , where Tuse is the time to adoption at the anticipated utilization rate plus time to vaccine licensure.

cAmortized development cost=Development costs×r.



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