. "Overview of Analytic Approach and Results." Vaccines for the 21st Century: A Tool for Decisionmaking. Washington, DC: The National Academies Press, 2000.
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Vaccines for the 21st Century: A Tool for Decisionmaking
Cost per QALY gained with vaccine
a.
Immediately available vaccine (100% efficacy and use, no development cost or time)
$89,660
b.
Immediately available vaccine with likely effect and use (no development cost or time)
$123,816
c.
Vaccine available with addition of development cost and time
$125,980
QALYs to Be Gained
Net Cost
Cost of Care Saved
Delivery Costs
Development Costs
a.
Baseline
Immediately available vaccine (100% efficacy and use, no development cost or time)
7,026.64
$630,009,848
$89,990,152
$720,000,000
$240,000,000
b.
Adjustments for Vaccine Efficacy and Utilization
Anticipated vaccine efficacy: 75%
5,269.98
$67,492,614
N/A
N/A
Anticipated vaccine utilization: 90%
4,742.98
$587,256,647
$60,743,353
$648,000,000
N/A
c.
Adjustment for Vaccine Development Costs and Time
Vaccine available with addition of development cost and time
aNot applicable for Vaccine X-1; relevant for other Vaccine X examples.
bAnnualize present value=(adjusted baseline)/(l+r)Tuse , where Tuse is the time to adoption at the anticipated utilization rate plus time to vaccine licensure.
