|
Items in cart [0] |
Questions? Call 888-624-8373 |
HARDBACK PDF BOOK Free Resources |
||||||||||||||||
|
||||||||||||||||
|
|
|||||||||||||||
| ||||||||||||||||||||||||||||||
|
||||||||||||||||||||||||||||||
| Copyright © 2009. National Academy of Sciences. All rights reserved. Terms of Use and Privacy Statement |
Below are the first 10 and last 10 pages of uncorrected machine-read text (when available) of this chapter, followed by the top 30 algorithmically extracted key phrases from the chapter as a whole.
Intended to provide our own search engines and external engines with highly rich, chapter-representative searchable text on the opening pages of each chapter.
Because it is UNCORRECTED material, please consider the following text as a useful but insufficient proxy for the authoritative book pages.
Do not use for reproduction, copying, pasting, or reading; exclusively for search engines.
OCR for page 161
OCR for page 162
HERBERT McLEAN EVANS
September 23, Z8S2-March 6, 1971
BY GEORGE W. CORNER
HERBERT MCLEAN EVANS, anatomist, endocrinologist, and
bibliophile, was born in Modesto, California, Septem-
ber 23, 1882. His father, Clayburn Wayne Evans, a native of
Alabama, was the leading physician and surgeon in the then-
small town; he is said to have been the first in the upper San
Joaquin Valley to do abdominal surgery. Herbert Evans's
mother, nee Bessie McLean, came of a Virginia family. Her
father practiced medicine in Modesto, and her brother, Robert
McLean, was professor of surgery and dean of the San Francisco
medical faculty of the University of California. Dr. C. W. Evans
was a man of vigorous rather than polished character; Bessie
McLean Evans and her brother Robert were persons of refined
manners and tastes. Herbert Evans thus began life in a strongly
medical family and with a varied store of traits and tem-
peraments.
He attributed much of his early interest in science, literature,
and history to a cultivated high school principal in his home
town and the excellent library at the school. This exposure to
books in boyhood was fortunate, for with his family background
and strong pressure from his father it was inevitable that the
young man should enter the medical profession and that his
college education (at Berkeley) would be directed to that end, at
the expense of cultural interests. Indeed, his father seems to
153
OCR for page 163
154
BIOGRAPHICAL MEMOIRS
have been dubious about letting him have more than the two
years of premedical preparation then required; and young Evans
himself concentrated the rest of his college years on science.
Among his teachers, one who especially won his admiration was
the celebrated paleontologist John C. Merriam, who during
Evans's senior year in college took him on a field trip to Idaho.
Evans's first published contribution to science, about the time of
his graduation from college, was the description of a fossil fish
spine from the Triassic of Idaho, which Merriam encouraged
him to study.
In college, Evans distinguished himself sufficiently to be, at
the commencement of 1904, one of the two students then custo-
marily chosen to deliver brief graduation addresses. He spoke
on the importance of biological research for human welfare.
In the autumn he enrolled in the medical school of the uni-
versity, in whose Berkeley laboratories he pursued the courses
of the first year of professional study. The professor of anatomy
was Joseph Marshall Flint, a surgeon who had done some ana-
tomical research at Johns Hopkins and a stimulating lecturer;
his associates were Irving Hardesty, a productive histologist, and
Robert Orton Moody, a competent teacher of gross human
anatomy.
The next summer Evans boldly took two steps that were
quite contrary to his parents' judgment. In the first place he
decided not to continue the study of medicine at the University
of California, but instead to go to the School of Medicine of
Johns Hopkins University where, his father feared, his leaning
toward science might turn him away from the practice of medi-
cine. The other, equally bold step was to marry his college
sweetheart, Anabel Tulloch, like him tall and handsome, and in
her way as spirited and impetuous as he. Since her family also
strongly disapproved the match, the young people were married
privately and departed for Baltimore.
OCR for page 164
HERBERT MCLEAN EVANS
155
At that time married medical students were unheard of at
Johns Hopkins and most other medical schools. Fearing that he
might not be admitted, Herbert concealed his marriage from the
admissions office. He and Anabel set up housekeeping at some
distance from the school, where in a poor city neighborhood the
bride from California's broad and verdant spaces was cooped up
and separated from her husband all day long, among unintel-
lectual neighbors, seeing nothing of his associates and activities,
feeling lonely and neglected. Years afterward each of them
separately spoke to the writer of this memoir about that strange
interlude, he with an expression of remorse, she with a trace
of lingering resentment, but each realizing that their sacrifice
had helped to put Evans on the way to professional achievement.
After about a year, the birth of their daughter Marian in the
Johns Hopkins Hospital ended the deception and Anabel's isola-
tion, although as the wife of an impecunious and intensely busy
student her'lot was still far from easy.
During his medical year at Berkeley, Evans had taken the
usual course in human anatomy with dissection. At Johns
Hopkins, at that time, second-year students were given con-
tinuing instruction in that subject, but the professor—Franklin
P. Mall, a shrewd and subtle judge of men—allowed Evans to
spend his time in the laboratory more or less as he wished.
Because Mall himself had engaged in research on the pattern
of microscopic blood vessels in various organs and in embryos,
Evans learned from him methods of injecting blood vessels with
colored fluids to make them readily visible. Working with finer
and finer glass cannulas, under the microscope, he became
expert. His special status in the laboratory gave him much
closer association with the departmental staff than he would
otherwise have had. Mall, the most influential anatomist in the
country, had gathered about him probably the strongest ana-
tomical research group in the English-speaking world, including
OCR for page 165
156 BIOGRAPHICAL MEMOIRS
Warren H. Lewis, Ross G. Harrison, and Florence R. Sabin—
all of them destined, as was Mall, to become members of the
National Academy of Sciences.
One day the school's professor of surgery, the austerely
scientific William H. Halsted, came to Mall for help with a
clinical problem. A patient of his, following an operation on
the thyroid gland. had developed acute tetany. Knowing of
other surgical mishaps of the same kind, Halsted rightly con-
jectured that he had inadvertently either removed the incon-
spicuous but indispensable parathyroid glands along with the
thyroid, or had tied off their blood supply. He felt that with
more exact knowledge of the small arteries supplying the para-
thyroids, operations could be planned to conserve the glandules.
Mall arranged for Evans to take on the problem under Halsted's
supervision. By injection and careful dissection of the branches
of the thyroid arteries in a few cadavers, Evans solved the prob-
lem, and thus his name appeared with Halsted's at the head of an
authoritative little article that appeared in Annals of Surgery in
1907 while the junior author was still a medical student. In the
same year Evans published in the American Journal of Anatomy
a very creditable article on the blood circulation in the walls
of large lymphatic vessels, illustrated with his own drawings
made in the style of the great Johns Hopkins medical artist
Max Broedel. About the same time he had begun research on
embryonic blood vessels. Before taking his medical degree he
completed a study of the earliest vessels in the limb buds of chick
embryos, which he published in full in 1909. Another significant
accomplishment while a medical student was his demonstration
of the growth of lymphatic vessels into a malignant tumor, pub-
lished in 1908.
While Evans was thus exhibiting his remarkable talent for
anatomical investigation, Franklin Mall missed no occasion to
foster his training for a professional career. He not only en-
couraged Evans's research, but had him write book reviews for
OCR for page 166
HERBERT MCLEAN EVANS
157
the Anatomical Record, then being published from Mall's labo-
ratory, and finally gave him a quite extraordinary opportunity
for so young a man. In 1907, Mall was organizing, jointly with
Franz Keibel of Freiburg, Baden, Germany, their great Manual
of Human Embryology (1910, Philadelphia and Leipzig), to
be written by leading investigators of Germany and America.
When a European embryologist who was to contribute a section
on the blood-vascular system was unable to do so, Mall entrusted
the task to Evans. Too ambitious merely to compile what was
already known, Evans prepared himself for the assignment not
only by studying the literature and then examining well-under-
stood human embryos in Mall's collection but also by making
original observations on the little-known earliest development
of the aorta and the other great vessels. By extremely skillful
injection of chick embryos, working under the microscope, he
proved—against the supposition of Hochstetter and others—that
these ultimately large channels begin, as do the peripheral
arteries and veins, as a network of capillaries. This fundamental
observation was the basis of Evans's authoritative contribution
to the Keibel-Mall Manual, Chapter X\7III, Section III.
From the first, Evans felt little interest in the clinical courses
at Johns Hopkins, particularly when they took his time from
such exciting activities as injecting embryonic blood vessels. He
cut classes without regard to consequences. A preposterous
story got abroad that he was granted his medical diploma only
on his promise that he would never practice medicine. He him-
self contributed to the persistence of such legends by his own,
equally apocryphal statements that he was expelled from the
medical school at the end of his third year for incompetence in
surgical bandaging, obstetrical manikin exercises, and prescrip-
tion-writing and was only restored to academic status with the
help and advice of Dr. William H. Howell, then dean of the
school. No doubt he did neglect such practical routines, but in
~ Bulletin of the Johns Hopkins Hospital, 6S, 300 (~947) .
OCR for page 167
158
BIOGRAPHICAL MEMOIRS
sober fact the records of the medical school do not mention any
disciplinary action ever taken with respect to H. M. Evans, and
he was graduated in medicine in 1908.
Immediately afterward he joined Mall's department as
assistant in anatomy and by this step confirmed, as his father had
been fearing for some years, that he would not return to
Modesto to assist with and later take over the older man's
practice. To the senior Dr. Evans this was a heavy blow, for he
thought practice far more important than research. It was
undoubtedly the feeling that his father undervalued his choice
of career that instilled in Herbert Evans an urgent desire to
impress his parents by success in his chosen work and in later
life to win the highest academic honors.
While Evans remained at Johns Hopkins, Mall arranged
several times for him to go to Germany in the summer vacations.
During a stay at Freiburg he was fascinated by the novel experi-
ments of the surgeon Erwin Goldman on intravitam staining of
animal tissues by acid azo dyes (e.g., trypan blue). With a young
Freiburg chemist, Werner Schulemann, he began experiments
to find out whether the spectacular coloration, inside and out,
of living rats, mice, and rabbits by injection of such dyes is a
physical or chemical phenomenon. Continuing the work for
some years, he found that these dyes do not truly dissolve in the
body fluids, but are dispersed as extremely fine particles, form-
ing a fluid suspension. When injected under a rat's skin, the
dyestuff gets into the bloodstream as submicroscopic aggregates
that the macrophage cells of connective tissues take up and then
store in their cytoplasm. The recognition of this important class
of cells and their role in the storage of particulate matter was
much forwarded by Evans's work. Among the numerous dyes
he and Schulemann studied, one now called Evans blue proved
~ Information kindly supplied by Mary E. Foy, Registrar, School of Medicine,
Johns Hopkins University.
OCR for page 168
HERBERT MCLEAN EVANS
159
useful in a method of measuring the blood volume of living ani-
mals and human surgical patients.
As a member of Mall's staff, Evans was busy with teaching,
with his work on vital staining, and with studying the blood
vessels of pig and chick embryos as well as of human embryos on
the rare occasion when one was received in a sufficiently fresh
state to be injected with indict ink. In 1913, on obtaining funds
from the Carnegie Institution of Washington for the support of
his large collection of human embryos and to develop research in
that field, Mall created the department of embryology of the
Carnegie Institution. This was first housed in the Johns Hop-
kins anatomical laboratory and later in part of an adjacent new
building. Evans, who was given a Carnegie appointment con-
currently with his Johns Hopkins post, then devoted a good
deal of his time to the sectioning of early human embryos and
to reconstructing them in wax from the sections—"A wearisome
thing to do," he said, "compared with making the living embryo
pump indict ink as though it were blood to show the multi-
tudinous vascular channels."
This strong inclination to experimental rather than purely
morphological research was a partial cause of Evans's dropping a
major project that Mall had suggested, a descriptive study of the
human embryo during the period of somite formation. Another
reason was that when Evans finally deft Baltimore, Mall was
unwilling to let him take along, even for his temporary use, the
rare and precious serially sectioned embryos necessary for the
study—one or two of which, at least, Evans had himself collected
and laboriously sectioned during Mall's summer absences. Evans
was disappointed and hurt by what he regarded as his chief's
ungenerosity. However, a few years later when Mall died in the
prime of life with the rift between them still unhealed, Evans
was deeply grieved. As a kind of penance for his part in the
disagreement, he proposed to write a biography of Mall, hinting
OCR for page 169
160
BIOGRAPHICAL MEMOIRS
that this would be a profound analysis of a distinguished scien-
tific mind (as indeed it might well have been), but in time the
plan was forgotten. Evans's work on the embryos, however, was
not lost. Several years later G. W. Bartelmez of the University of
Chicago took up the study of the somite stage of human develop-
ment, first studying the Carnegie embryos in Baltimore, then
going to Berkeley to secure Evans's collaboration and the use of
his notes and drawings. The result was an important mono-
graph in the Carnegie Contributions to Embryology (~1926'
under their joint authorship.
In 1915, when Evans was in his thirty-third year, President
Benjamin Ide Wheeler of the University of California offered
him the chair of anatomy at Berkeley vacated by the departure of
Flint in 1907 and of his acting successor, Irving Hardesty, in
1909. Since then, the direction of the department had reverted
to the worthy pedagogue Robert O. Moody, under whom Evans
a dozen years before had studied gross human anatomy. Research
had practically ceased. Even routine teaching had suffered
because of Moody's frail health and the illness of another mem-
ber of the small staff. Philip E. Smith was the only man left
in the department who was in good health and had sufficient
experience to teach gross and microscopic anatomy. During the
year before Evans's advent, Smith and his wife, who had done
some postgraduate work in biology, had carried almost the
entire teaching load, to the detriment of the research program
in experimental embryology that Smith had brought with him
from Cornell.
To build up the department, Evans took with him from
Johns Hopkins two young people who had shown competence
for anatomical research—Katherine l. Scott (now Katherine
Scott Bishop), a medical graduate of 1915, and George W.
Corner, who was just completing an internship in the women's
clinic. "Gynecologists ought to know more about the female re-
productive cycle," said Dr. Evans to Corner. "Come to Berkeley
OCR for page 170
HERBERT MCLEAN EVANS
161
with me and do your gynecology for a while on rats and rabbits."
At Berkeley, recognizing Philip Smith's great abilities, Evans ar-
ranged for him a much-lightened teaching schedule and in every
possible way facilitated the research that ultimately won for
Smith an international reputation and the chair of anatomy at
Columbia University. It was during this early period that Smith
perfected his operation of hypophysectomy in the rat, which
became an invaluable procedure in research on the pituitary
gland. Associate Professor Moody, perhaps a little surprised by
the inrush of all this youthful enthusiasm, retained charge of
gross anatomy, with Smith and one of the newcomers helping
him.
With the staff thus fully manned, the reorganized depart-
ment resumed its work in the autumn of 1919 in a small frame
building, once the university's printing shop, that had been
adapted for the teaching of human anatomy when the San
Francisco earthquake and fire of 1906 forced the transfer of pre-
clinical classes to Berkeley. Evans took teaching quite seriously,
in his own way, which was tinctured with the pride of intellect
he never concealed. His course in histology was radically new in
its extensive use of fresh and experimentally prepared tissues
along with the traditional fixed and routinely stained sections.
In the class laboratory he was usually to be seen at the micro-
scope beside one of the better students. With the general run
he was tolerant; with the duller minds, barely so and occasionally
sarcastic. He did not believe in lecturing on gross anatomy, a
finished science, but his lectures on microscopic anatomy were
superb from the standpoint of his staff, for whom they consti-
tuted a postgraduate course. As for the medical students, he was
heard to say that he aimed his lectures at only the four or five
best students in the class (of forty), tacitly implying that the
assistant professors and instructors could take care of the rest.
For the best ten percent the instruction (or, it might be more
correct to say, the freedom to learn) provided by this brilliant
OCR for page 171
162
BIOGRAPHICAL MEMOIRS
professor opened new vistas in medical science. Years later
Elmer Belt, a member of the first class Evans taught at Berkeley
and now California's most distinguished urologist, wrote of
Evans and his young associates that "The effect of their scholar-
ship and idealism upon the freshman class in medicine was
electric. Each of us realized how great an opportunity it was to
enter the study of medicine under their guidance and for us
the study of medicine became an obsession. The routine work
of gross dissection and histology was time-consuming but most
of us, in addition, were stimulated to take up a separate problem
in research. We were thus led to seek out and read recent con-
tributions to the literature concerned with our special subjects.
This pursuit inevitably led us to doubt didactic textbook state-
ments unless verified by our own personal observations. This
atmosphere of doubt and verification prevailed through the
department and led to intense application. For most of us this
was our first taste of scholarly research." ~
Departmental administration was for Herbert Evans a duty
reluctantly borne. His compulsive urge to work intensively at
research led him to put off administrative routine, the writing of
articles against deadlines, and other less congenial tasks until
the last minute. Thus the course of departmental affairs was in-
terrupted from time to time by minor or even major crises. One
of these in the early Berkeley days, somewhat mysterious to
Evans's associates, evidently caused him deep concern. He and
his secretary for several days were intently busy, occupied with
account books and the adding machine. Evans's brother, a busi-
nessman familiar with accounting, was called in; there were
urgent messages to and from the university bursar's office. Prob-
ably the professor had overrun his budget. On another occasion
he was overtaken by the deadline for an article long promised
~ Elmer Belt in There Was Light: Autobiography of a University, Berkeley,
1868-1969, ed: Irving Stone, Doubleday & Co., Garden City New York, 1970, p.
354.
OCR for page 192
HERBERT MCLEAN EVANS
183
With K. Meyer, M. E. Simpson and F. L. Reichert. Disturbance of
carbohydrate metabolism in normal dogs injected with the
hypophyseal growth hormone. Proc. Soc. Exp. Biol. Med., 29:85-
88.
1932
Vitamin E. l. Am. Med. Assoc., 99:469-75.
With Samuel Lepkovsky. Vital need of the body for certain un-
saturated fatty acids. I. Experiments with fat-free diets in which
sucrose furnishes the sole source of energy. l. Biol. Chem.,
96: 143-56.
1933
With M. E. Simpson and P. R. Austin. The hypophyseal substance
giving increased gonadotropin effects when combined with
prolan. journal of Experimental Medicine, 57:897-906.
With K. Meyer, M. E. Simpson, A. l. Szarka, R. I. Pencharz, R. E.
Cornish and F. L. Reichert. The growth and gonad-stimulating
hormones of the anterior hypophysis. Mem. Univ. Calif., 11:446
PP
1934
First editions in the history of science. In: Exhibition of First Edi-
tions of Epochal Achievements in the History of Science. Spon-
sored by the History of Science Club, University of California,
Berkeley. (Pamphlet, privately printed)
With S. Lepkovsky and Elizabeth A. Murphy. Vital need of the
body for certain unsaturated fatty acids. IV. Reproduction and
lactation upon fat-free diets. i. Biol. Chem., 106:431-40.
With S. Lepkovsky and Elizabeth A. Murphy. Vital need of the
body for certain unsaturated fatty acids. VI. Male sterility on
fat-free diets. l. Biol. Chem., 106:445-50.
1935
With M. E. Simpson and R. I. Pencharz. "Deficiency" changes in
the testicular Leydig cells after hypophysectomy. Anat. Record,
61 (abstr. supp.) :44.
OCR for page 193
184 BIOGRAPHICAL MEMOIRS
With Miriam E. Simpson. Production of superovulation in normal
immature rats by injection of the principle in menopause urine.
Proc. Soc. Exp. Biol. Med., 32:1946~7.
1936
With Oliver H. Emerson and Gladys A. Emerson. The isolation
from wheat germ oil of an alcohol, <~-tocopherol, having the
properties of vitamin E. l. Biol. Chem., 113: 319-32.
With Karl Korpi, M. E. Simpson, R. I. Pencharz and D. H. Wonder.
On the separation of the interstitial cell-stimulating, luteinizing
and follicle-stimulating fractions in the anterior pituitary go-
nadotropic complex. University of California Publications in
Anatomy, 1 :255-73.
1937
With Clara L. Kohls and D. H. Wonder. Gonadotropic hormone in
the blood and urine of early pregnancy; the normal occurrence
of transient extremely high levels. l. Am. Med. Assoc., 108:287-
89.
With Nellie Halliday. On the fractionation of the vitamin B2 com-
plex from various source materials. I. Biol. Chem., 118:255-67.
With M. E. Simpson and R. I. Pencharz. An anterior pituitary
gonadotropic fraction (ICSH) specifically stimulating the inter-
stitial tissue of testis and ovary. Cold Spring Harbor Symposium
on Quantitative Biology, 5:229~0.
lg38
With Dwight J. Ingle and H. D. Moon. Work performance of
hypophysectomized rats treated with anterior pituitary extracts.
Am. J. Physiol., 123:620-24.
The hypophyseal growth hormone- Its separation from the hor-
mones stimulating the thyroid, gonads, adrenal cortex and mam-
mary glands. Research Publications of the Association for
Research in Nervous and Mental Disease (Proceedings, 1936),
17: 175-92.
1939
With O. H. Emerson, G. A. Emerson, Lee Irvin Smith, Herbert E.
Ungnade, W. W. Prichard, F. L. Austin, H. H. Hoehn, J. W.
OCR for page 194
HERBERT MCLEAN EVANS
185
Opio and S. Wawzonek. The chemistry of vitamin E. XIII.
Specificity and relationship between chemical structure and
vitamin E activity. Journal of Organic Chemistry, 4:376-88.
1940
With Nobuko Shimotori and G. A. Emerson. The prevention of
nutritional muscular dystrophy in guinea pigs with vitamin E.
J. Nutr., 19: 547-54.
With i. Fraenkel-Conrat, Heinz Fraenkel-Conrat and M. E. Simp-
son. Purification of thyrotropic hormone of the anterior pitui-
tary. l. Biol. Chem., 135:199-212.
With H. Fraenkel-Conrat and M. E. Simpson. Purification of the
follicle stimulating hormone of the anterior pituitary. Anales
de la Facultad de Medicina de Montevideo, 25: 617-26. Re-
printed in: Anales de la Facultad de Medicina de Montevideo:
numero especial con motive del homenaje que la "Sociedad de
Biologia de Montevideo" ofrece al Prof. Ludwig Fraenkel, en
occasion del 70.° aniversario de su nacimiento, pp. 159-68.
With H. L. Fraenkel-Conrat, Donald L. Moamber and M. E. Simp-
son. Further purification of the growth hormone of the anterior
pituitary. Endocrinology, 27: 605-13.
With H. Fraenkel-Conrat, Choh Hao Li and M. E. Simpson. In-
terstitial cell stimulating hormone. I. Biological properties.
Endocrinology, 27: 793-802.
N\lith Choh Hao Li and M. E. Simpson. Interstitial cell stimulating
hormone. II. Method of preparation and some physico-chem-
ical studies. Endocrinology, 27: 803-8.
With H. Fraenkel-Conrat and M. E. Simpson. Interstitial cell stim-
ulating hormone. III. Methods of estimating the hormonal
content of pituitaries. Endocrinology, 27: 809-17.
With M. E. Simpson and William R. Lyons. Influence of lactogenic
preparations on production of traumatic placentoma in the rat.
Proc. Soc. Exp. Biol. Med., 46:586-90.
1941
With W. R. Lyons and M. E. Simpson. Influence of lactogenic
preparations on mammary glands and time of vaginal opening
in young rats. Proc. Soc. Exp. Biol. Med., 48:634-37.
OCR for page 195
186
BIOGRAPHICAL MEMOIRS
With Hermann Becks, Edwin A. Kibrick and Walter Marx. The
early effect of hypophysectomy and of immediate growth hor-
mone therapy on endochondral bone formation. Growth 5:449-
56.
1942
With W. Marx and M. E. Simpson. Bioassay of the growth hor-
mone of the anterior pituitary. Endocrinology, 30:1
With H. L. Fraenkel-Conrat, V. V. Herring and M. E. Simpson.
Effect of purified pituitary preparations on the insulin content
of the rat's pancreas. Am. I. Physiol., 135:404.
With M. E. Simpson, E. A. Kibrick and H. Becks. Effect of crystal-
line estrin implants on the proximal tibia and costochondral
junction of young female rats. Endocrinology, 30:286.
With W. Marx, M. E. Simpson and W. O. Reinhardt. Response to
growth hormone of hypophysectomized rats when restricted to
food intake of controls. Am. l. Physiol., 135:614.
With W. Marx and M. E. Simpson. Synergism between thyrotropic
and growth hormones of pituitary. Body weight increase in
hypophysectomized rat. Proc. Soc. Exp. Biol. Med., 49:594.
With A. Gorbman. Urinary gonadotrophins in normal men. Proc.
Soc. Exp. Biol. Med., 49:674.
With M. E. Simpson and G. H. Li. Biological properties of pitui-
tary interstitial cell-stimulating hormone (ICSH). Endocrinology,
30:969.
With E. A. Kibrick, M. E. Simpson and H. Becks. Effects of crystal-
line estrin implants on the tibia of young hypophysectomized
female rats. Endocrinology, 31:93.
With C. H. Li and M. E. Simpson. Isolation of adrenocortico-
tropic hormone from sheep pituitaries. Science, 96:450.
1943
With M. E. Simpson, W. Marx and E. Kibrick. Bioassay of the
pituitary growth hormone. Width of the proximal epiphyseal
cartilage of the tibia in hypophysectomized rats. Endocrinology,
32:13.
With A. Gorbman. Beginning of function in the thyroid of the fetal
rat. Endocrinology, 32: 1 13.
OCR for page 196
HERBERT MCLEAN EVANS
187
With W. R. Lyons and M. E. Simpson. Hormonal requirements for
pregnancy and mamary development in hypophysectomized
rats. Proc. Soc. Exp. Biol. Med., 52:134.
With W. Marx, M. E. Simpson and C. H. Li. Antagonism of pitui-
tary adrenocorticotropic hormone to growth hormone in hypo-
physectomized rats. Endocrinology, 33: 102.
With C. H. Li and M. E. Simpson. Adrenocorticotropic hormone.
I. Biol. Chem., 149:413.
With M. E. Simpson and C. H. Li. Inhibiting effect of adrenocor-
ticotropic hormone on the growth of male rats. Endocrinology,
33:237.
With M. E. Simpson, C. H. Li and W. O. Reinhardt. Similarity of
response of thymus and lymph nodes to administration of adre-
nocorticotropic hormone in the rat. Proc. Soc. Exp. Biol. Med.,
54:135.
With M. E. Simpson and C. H. Li. Bioassay of adrenocorticotropic
hormone. Endocrinology, 33:261.
With G. A. Emerson. The prophylactic requirement of the rat for
alpha tocopherol. J. Nutr., 26:555.
1944
With Gladys A. Emerson. The bioassay of vitamin E. l. Nutr.,
27:469.
With H. Becks, M. E. Simpson, W. Marx and C. H. Li. Antagonism
of pituitary adrenocorticotropic hormone (ACTH) to the action
of growth hormone on the osseous system of hypophysectomized
rats. Endocrinology, 34:311.
With M. E. Simpson, W. Marx and H. Becks. Response to acre
nalectomized-hypophysectomized rats to the pituitary growth
hormone. Endocrinology, 35:234.
With Miriam E. Simpson, W. Marx and H. Becks. Effect of
testosterone propionate on the body weight and skeletal system
of hypophysectomized rats. Synergism with pituitary hormone.
Endocrinology, 35:309.
1945
With C. H. Li and M. E. Simpson. Isolation and properties of the
anterior hypophyseal growth hormone. i. Biol. Chem. 159:353.
OCR for page 197
188
With G. S. Gordan, C. H. Li
BIOGRAPHICAL MEMOIRS
1946
and L. L. Bennett. Effect of adreno-
corticotrophic hormone on urinary nitrogen excretion in the
normal rat. Proc. Soc. Exp. Biol. Med., 62:103.
With M. E. Simpson. Sensitivity of the reproductive system of
hypophysectomized forty-day-old male rats to testosterone pro-
pionate. Endocrinology, 39:75.
With M. E. Simpson. Comparison of the spermatogenic and andro-
genic properties of testosterone propionate with those of pituitary
ICSH in hypophysectomized 40-day-old male rats. Endocrinol-
°gY, 39:281.
1947
With Marjorie M. Nelson. Growth, reproduction and lactation in
the rat maintained on purified diets. Archives of Biochemistry,
12:213.
Recent progres de nos connaissances sur les hormones du lobe
anterieur de l'hypophyse. Journal de Physiologic (Paris), 39: 121.
With C. H. Li. The properties of the growth and adrenocortico-
tropic hormones. Vitamins and Hormones, 5:197.
1948
With Miriam E. Simpson and C. H. Li. The gigantism produced
in normal rats by injection of the pituitary growth hormone.
I. Body growth and organ changes. Growth, 12:15.
With A. A. Koneff, M. E. Simpson and C. H. Li. The gigantism
produced in normal rats by injection of the pituitary growth
hormone. II. Histological changes in the pituitary. Growth,
12:33.
With C. H. Li and M. E. Simpson. The gigantism produced in
normal rats by injection of the pituitary growth hormone. III.
Main chemical components of the body. Growth, 12:39.
With H. Becks, C. Willet Asling, M. E. Simpson and C. H. Li. The
gigantism produced in normal rats by injection of the pituitary
growth hormone. IV. Skeletal changes: Tibia, costochondral
junction, and caudal vertebrae. Growth, 12:43.
With H. Becks, D. A. Collins, C. W. Asling, M. E. Simpson and
C. H. Li. The gigantism produced in normal rats by injection
OCR for page 198
HERBERT MCLEAN EVANS
189
of the pituitary growth hormone. V. Skeletal changes: Skull
and dentition. Growth, 12:55.
With C. H. Li. Chemistry of anterior pituitary hormones. In:
The Hormones, ed. by G. Pincus and K. V. Thimann, Vol. I,
p. 631. New York, Academic Press, Inc.
1949
With F. S. Greenspan, C. H. Li and M. E. Simpson. Bioassay of
hypophyseal growth hormone: The tibia test. Endocrinology,
45:455.
The search for the diabetogenic principle of the anterior hypophysis.
(The Banting Memorial Address y Proceedings of the American
Diabetes Association, 9:49.
1950
With H. D. Moon, M. E. Simpson and C. H. Li. Neoplasm in rats
treated with pituitary growth hormone. Cancer Res., 10:364.
With H. D. Moon, M. E. Simpson and C. H. Li. Neoplasms in rats
treated with pituitary growth hormone. III. Reproductive or-
gans. Cancer Res., 10:549.
With M. E. Simpson. Physiology of the gonadotrophins. In: The
Hormones, ed. by G. Pincus and K. V. Thimann, Vol. II, Chap.
VI, p. 351. New York, Academic Press, Inc.
The hypophysis and diabetes mellitus. In: The Hormones, ed. by
G. Pincus and K. V. Thimann, Vol. II, Chap. VIII, p. 405. New
York, Academic Press, Inc.
With M. E. Simpson and C. Willet Asling. Some endocrine in-
fluences on skeletal growth and differentiation. Yale Journal of
Biology and Medicine, 23:1.
With D. C. Van Dyke, M. E. Simpson and C. H. Li. Survival in the
circulation of the growth and adrenocorticotrophic hormones as
evidenced by parabiosis. Am. J. Physiol., 163:297.
1951
With A. A. Koneff, H. I). Moon, M. E. Simpson and C. H. Li. Neo-
plasms in rats treated with pituitary growth hormone. IV. Pitui-
tary gland. Cancer Res., 1 1 : 1 13.
With Marjorie M. Nelson. Effect of pyridoxine on reproduction
of the rat. J. Nutr., 43: 281.
OCR for page 199
190
BIOGRAPHICAL MEMOIRS
With H. D. Moon, M. E. Simpson and C. H. Li. Neoplasms in rats
treated with pituitary growth hormone. V. Absence of neo-
plasms in hypophysectomized rats. Cancer Res., 11:535.
With Miriam E. Simpson and C. H. Li. Synergism between pitui-
tary follicle stimulating hormone (FSH) and human chorionic
gonadotropin (HCG). Endocrinology, 48:370.
With C. A. Gemzell, D. C. Van Dyke and C. A. Tobias. Increase
in the formation and secretion of ACTH following adre-
nalectomy. Endocrinology, 49:325.
1952
With H. D. Moon and M. E. Simpson. Inhibition of methyl-
cholanthrene carcinogenesis by hypophysectomy. Science, 116:
331.
With M. M. Nelson and C. W. Asling. Production of multiple
congenital abnormalities in young by maternal pteroylglutamic
acid deficiency during gestation. J. Nutr., 48:61.
With D. C. Walker, C. W. Asling, M. E. Simpson and C. H. Li.
Structural alterations in rats hypophysectomized at six days of
age and their correction with growth hormone. Anat. Record,
1 14:49.
With C. W. Asling, D. G. Walker, M. E. Simpson and C. H. Li.
Deaths in rats submitted to hypophysectomy at an extremely
early age and the survival effected by growth hormone. Anat.
Record, 1 14: 19.
With A. A. Koneff and D. C. Van Dyke. Increase in the thyrotropic
hormone content of blood after thyroidectomy as shown by
parabiosis. Endocrinology, 51:249.
1953
With Miriam E. Simpson, D. C. Van Dyke and C. W. Asling. Re-
generation of the calvarium in young normal and growth hor-
mone-treated hypophysectomized rats. Anat. Record, 115:615.
With M. M. Nelson and W. R. Lyons. Comparison of ovarian and
pituitary hormones for maintenance of pregnancy in pyri-
doxine-deficient rats. Endocrinology, 52: 585.
With M. M. Nelson. Relation of dietary protein levels to repro-
duction in the rat. J. Nutr., 51:71.
OCR for page 200
HERBERT MCLEAN EVANS
191
With R. A. Lyon and M. E. Simpson. Qualitative changes in urinary
gonadotrophins in human pregnancy during the period of rapid
increase in hormone titer. Endocrinology, 5 3:674.
1954
With R. D. Ray, C. W. Asling, D. G. Walker, M. E. Simpson and
C. H. Li. Growth and differentiation of the skeleton in thy-
roidectomized-hypophysectomized rats treated with thyroxin,
growth hormone, and the combination. journal of Bone and
Joint Surgery, 36: A94.
With Marjorie M. Nelson. Maintenance of pregnancy in the ab-
sence of dietary protein with estrone and progesterone. En-
docrinology, b5:543.
With Catherine D. C. Baird, M. M. Nelson and I. W. Monie. Con-
genital cardiovascular anomalies induced by pteroylglutamic
acid deficiency during gestation in the rat. Circulation Research,
2:544.
1955
With Eloise Wooten, M. M. Nelson and M. E. Simpson. Effect of
pyridoxine deficiency on the gonadotrophin content of the an-
terior pituitary in the rat. Endocrinology, 56:59.
With M. M. Nelson. Relation of thiamine to reproduction in the
rat. J. Nutr., 55:151.
With C. W. Asling, M. E. Simpson, H. D. Moon and C. H. Li.
Growth hormone induced bone and joint changes in the adult
rat. In: The Hypophyseal Growth Hormone, Nature and Action,
ed. by R. W. Smith, ir., et al., Chap. 9, p. 154. New York,
McGraw-Hill Book Co., Inc.
With M. M. Nelson, H. V. Wright and C. W. Asling. Multiple
congenital abnormalities resulting from transitory deficiency
of pteroylglutamic acid during gestation in the rat. I. Nutr.,
56:349.
1956
With C. W. Asling. Anterior pituitary regulation of skeletal de-
velopment. In: The Biochemistry and Physiology of the Bone,
ed. by G. H. Bourne, Chap. 21, p. 671. New York, Academic
Press, Inc.
OCR for page 201
192
BIOGRAPHICAL MEMOIRS
1958
Title E. Mrooten, NI. AI. Nelson and M. E. Simpson. Response of
vitamin B6-deficient rats to hypophyseal follicle-stimulating and
interstitial-cell-stimulating hormones. Endocrinology, 63:860.
1959
With M. M. Nelson. Dietary requirement for lactation in the rat
and other laboratory animals. In: Milk: Its Physiology and Bio-
chemistry, ed. by A. T. Cowie and S. K. Kon. New York,
Academic Press, Inc.
Editor. Men and Moments in the History of Science. Anniversary
volume commemorating founding of History of Science Dinner
Club, University of California campus, Sept. 12, 1933. Seattle,
University of Washington Press. 226 pp.
OCR for page 202
Representative terms from entire chapter:
mclean evans
