TABLE 4-10 Case Reports of Milk Alkali Syndrome (single dose/day) a
|
Studies |
Ca Intake (g/d) b |
Duration |
Mitigating Factors |
|
Abreo et al., 1993 |
9.6c |
>3 mo |
None reported |
|
3.6c |
>2 y |
None reported |
|
|
10.8d |
Not stated |
None reported |
|
|
Brandwein and Sigman, 1994 |
2.7c |
2 y, 8 mo |
None reported |
|
Bullimore and Miloszewski, 1987 |
6.5d |
23 y |
Alkali in antacid |
|
Campbell et al., 1994 |
5d |
3 mo |
None reported |
|
Carroll et al., 1983 |
4.2d |
30 y |
None reported |
|
2c |
5 y |
None reported |
|
|
3.8d |
2 mo |
Vitamins A and E |
|
|
2.8d |
10 y |
NaHCO3, 5 g/d |
|
|
French et al., 1986 |
8c |
2 y |
None reported |
|
4.2c |
>2 y |
Thiazide |
|
|
Gora et al., 1989 |
4c |
2 y |
Thiazide |
|
Hart et al., 1982 |
10.6d |
Not stated |
NaHCO3, 2 g/d |
|
Kallmeyer and Funston, 1983 |
8d |
10 y |
Alkali in antacid |
|
Kapsner et al., 1986 |
10d |
10 mo |
None reported |
|
6.8d |
7 mo |
None reported |
|
|
4.8c |
2 d |
10-y history of antacid use |
|
|
Kleinman et al., 1991 |
16.5d |
2 wk |
10-y history of antacid use |
|
Lin et al., 1996 |
1.5c |
4 wk |
None reported |
|
Muldowney and Mazbar, 1996 |
1.7c |
13 mo (52 wk) |
None reported |
|
Schuman and Jones, 1985 |
9.8d |
20 y |
None reported |
|
4.8d |
6 wk |
10-y history of antacid intake |
|
|
Whiting and Wood, 1997 |
2.4c |
>1 y |
None reported |
|
Whiting and Wood, 1997 |
2.3–4.6c |
>1 y |
None reported |
|
Number of Subjects |
26 |
||
|
Mean |
5.9 |
3 y, 8 mo |
|
|
Median |
4.8 |
13 mo |
|
|
Range |
1.5–>16.5 |
2 d–23 y |
|
|
a Case reports of patients with renal failure are not included in this table. b Intake estimates provided by Whiting and Wood (1997). c Calcium intake from supplements only. d Calcium intake from supplements and diet. |
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