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milligrams per cubic meter, and exposure duration (t), usually in minutes.2 Ct refers to the product of concentration and exposure time. LCt50s were derived for either inhalation or percutaneous vapor exposures. It is important to note that the product of concentration and exposure duration (c × t) is not necessarily a constant.
ECt50 is the exposure to a vapor causing a defined effect in 50% of a given population and is expressed as the product of c × t in mg-min/m3, where c × t is not necessarily a constant. The effects include those classified as threshold (minimal), mild (miosis and/or rhinorrhea), or severe (incapacitation, prostration, collapse, and convulsions). ECt50s were derived for either inhalation or percutaneous vapor exposures.
ICt50 is the exposure to a vapor causing incapacitation in 50% of a given population and is expressed as the product of c × t in mg-min/m3, where c × t is not necessarily a constant.
LD50 is the acute dose of a liquid agent causing lethality in 50% of a given population and is expressed in milligrams per kilogram of body weight (mg/kg). In this report, all LD50s are for percutaneous liquid exposure of bare skin.
ID50 is the acute dose of a liquid agent causing incapacitation in 50% of a given population and is expressed in mg/kg. In this report, all ID50s are for percutaneous liquid exposure of bare skin.
ED50 is the acute dose of a liquid agent causing a defined effect in 50% of a given population and is expressed in mg/kg. In this report, all ED50s are for percutaneous liquid exposure of bare skin. Effects include those in the threshold, mild, or severe (including incapacitation) categories.
The results of the subcommittee's deliberations are presented in Chapters 2 through 8 of this report. Chapters 2 through 7 review CDEPAT's proposed human-toxicity estimates for agents GA, GB, GD, GF, VX, and HD, respectively. Those chapters provide conclusions on the scientific validity of the proposed acute human-toxicity estimates and recommendations for research efforts. Chapter 8 evaluates the risk-estimation procedures used in the CDEPAT report. The Appendix discusses the offensive versus the defensive use of human-toxicity estimates for CW agents.
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