Below is the uncorrected machine-read text of this chapter, intended to provide our own search engines and external engines with highly rich, chapter-representative searchable text of each book. Because it is UNCORRECTED material, please consider the following text as a useful but insufficient proxy for the authoritative book pages.
REVIEW OF ACUTE HUMAN-TOXICITY ESTIMATES FOR GA (TABUN) 20 2â Review of Acute Human-Toxicity Estimates for GA (Tabun) GA (Tabun or ethyl n-dimethylphosphoramidocyanidate) is an organophosphate nerve agent and is a colorless, volatile liquid. The physical and chemical properties, toxicokinetics, and toxicity of GA are discussed in detail by CDEPAT (1994), Marrs et al. (1996), and Somani (1994). Human-toxicity estimates have been derived for percutaneous vapor exposures, vapor inhalation, and percutaneous liquid exposures. Only four toxicity end points were consideredâlethality in animals, incapacitation, changes in cholinesterase (ChE) activity, and ocular changes in men and monkeys. The subcommittee's assessment of the scientific validity of CDEPAT's proposed human-toxicity estimates for GA is discussed below. PERCUTANEOUS VAPOR EXPOSURE Lethal Effects (LCt50) CDEPAT's proposed LCt50 estimate for percutaneous exposure to GA vapor is 15,000 mg-min/m3, assuming that soldiers are wearing light clothing