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Emerging Technologies for Nutrition Research: Potential for Assessing Military Performance Capability (1997)
Institute of Medicine (IOM)

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. "I Committee Summary and Recommendations." Emerging Technologies for Nutrition Research: Potential for Assessing Military Performance Capability. Washington, DC: The National Academies Press, 1997.

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Emerging Technologies for Nutrition Research: Potential for Assessing Military Performance Capability
  1. How practical is the technology? Will it require dedicated personnel and complex, exotic equipment? Will the data provided the difficult to analyze?

  2. Is the technique applicable to field testing scenarios (could it be used in the field or used to analyze data collected in the field such as frozen plasma samples)?

In Chapter 1, the committee presents an overview of the project using relevant background materials and the workshop proceedings from May 22–23, 1995. The committee then summarizes the techniques under consideration with regard to their state of the art, maturity and availability, practicality, military relevance, and complicating factors and methodological questions. Considered were techniques of body composition assessment, tracer techniques for the study of metabolism, ambulatory techniques for determination of energy expenditure, molecular and cellular approaches to nutrition, assessment of immune function, and functional and behavioral measures of nutritional status.

Before presenting its conclusions and recommendations in Chapter 2, the CMNR frames its answers to the questions posed by the Army in terms of the 6 techniques reviewed. Body composition assessment is used for accession and retention standards; while anthropometric measurements are most applicable for evaluating compliance, more sophisticated methods (such as dual-energy x-ray absorptiometry, magnetic resonance imaging, and computerized axial tomography) should be used to refine the anthropometric measurements. Noninvasive tracer techniques for the study of metabolism, such as stable isotopes, are militarily relevant and applicable in the field; however, the costs associated with trained personnel and expensive equipment need to be considered. Ambulatory monitoring techniques allow for measuring energy expenditure in the field and are in use. At the present time, molecular and cellular approaches should be confined to already-established research laboratories, even for issues of military interest. Studies of immune function and the development of vaccines and antibodies are of particular military relevance when considering the stress of military operations in relation to performance. The development of monitoring devices for evaluating cognitive performance in the field are similarly important.

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Front Matter (R1-R18)
I Committee Summary and Recommendations (1-2)
1 Project Overview and Committee Summary (3-50)
2 Committee Responses to Questions, Conclusions and Recommendations (51-68)
II The Current Army Program and Its Future Needs (69-70)
3 Emerging Technologies in Nutrition Research for the Military: Overview of the Issues (71-78)
III Techniques of Body Composition Assessment (79-80)
4 Military Application of Body Composition Assessment Technologies (81-126)
5 Imaging Techniques of Body Composition: Advantages of Measurement and New Uses (127-150)
6 Dual-Energy X-Ray Absorptiometry: Research Issues, and Equipment (151-168)
7 Bioelectrical Impedance: A History, Research Issues, and Recent Consensus (169-192)
Part III Discussion (193-198)
IV Tracer Techniques for the Study of Metabolism (199-200)
8 Stable Isotope Tracers: Technological Tools That Have Emerged (201-214)
9 Measurement of Energy Substrate Metabolism Using Stable Isotopes (215-230)
10 Combined Stable Isotope-Positron Emission Tomography for In Vivo Assessment of Protein Metabolism (231-258)
11 Nuclear Magnetic Resonance Studies of Liver and Muscle Glycogen Metabolism in Humans (259-272)
Part IV Discussion (273-278)
V Ambulatory Techniques for Measurement of Energy Expenditure (279-280)
12 Doubly Labeled Water for Energy Expenditure (281-296)
13 Measurement of Oxygen Uptake with Portable Equipment (297-314)
14 Advances in Ambulatory Monitoring: Using Foot Contact Time to Estimate the Metabolic Cost of Locomotion (315-344)
15 Noninvasive Measurement of Plasma Metabolites Using Near-Infrared Spectroscopy (359-360)
Part V Discussion (361-362)
VI Molecular and Cellular Approaches to Nutrition (363-374)
16 The Role of Metals in Gene Expression (375-388)
17 Metabolic Regulation of Gene Expression (389-400)
18 Use of Isolated-Cell and Metabolic Techniques Applied to Vitamin Transport and Disposition (401-414)
19 Assessment of Cellular Dysfunction During Physiologic Stress (415-416)
VII Assessment of Immune Function (417-430)
20 The Validity of Blood and Urinary Cytokine Measurements for Detecting the Presence of Inflammation (431-450)
21 New Approaches to the Study of Abnormal Immune Function (451-500)
Part VI and VII Discussion (501-504)
VIII Functional and Behavioral Measures of Nutritional Status (505-506)
23 Involuntary Muscle Contraction to Assess Nutritional Status (507-518)
24 Application of Cognitive Performance Assessment Technology to Military Nutrition Research (519-532)
25 New Techniques for Assessment of Mental Performance in the Field (533-550)
26 The Iowa Driving Simulator: Using Simulation for Human Performance Measurement (551-568)
Part VIII Discussion (569-576)
Appendixes (577-578)
Appendix A: Workshop Agenda (579-584)
Appendix B: Biographical Sketches (585-604)
Appendix C: Abbreviations (605-608)
Appendix D: Emerging Technologies for Nutrition Research - A Selected Biography (609-680)
Index (681-711)