some specific order relative to other isolating mechanisms (i.e., premating or postzygotic) has not been addressed. Negative assortative fertilization should promote outcrossing. Whether or not true self-incompatibility exists in Drosophila or other animals remains to be established, as does the nature of the interplay between negative assortative fertilization and other isolating mechanisms that act before or after fertilization.

Discussions with M.Wolfner and R.Richmond and with my former students S.Pitnick and R.Snook have been especially stimulating during the preparation of this manuscript. Bruce Wallace provided valuable editorial comments on an earlier draft. I also acknowledge the assistance of M. St. Louis, S.Murphy, S.Cleland, and S.Bertram and the support of National Science Foundation Grants INT 94–02161 and DEB 95–10645.

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