. "Appendix B: Summary Tables of Literature Reviewed for Safety of Halcion." Halcion: An Independent Assessment of Safety and Efficacy Data. Washington, DC: The National Academies Press, 1997.
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Halcion: An Independent Assessment of Safety and Efficacy Data
TABLE B-3 Displacement of [3H]Flumazenil in Rats as Determined by In Vivo Autoradiography
Cortex
Spinal Cord
Cerebellum
Drug
IC50 (mg/kg)
Ratio
IC50 (mg/kg)
Ratio
IC50 (mg/kg)
Ratio
Halcion
0.7 ± 0.1
1
0.1 ± 0.8
1
0.5 ± 0.08
1.0
Clonazepam
0.3 ± 0.07
0.04
0.3 ± 0.08
3
0.3 ± 0.07
0.6
Lorazepam
0.8 ± 0.3
1.1
1.0 ± 0.3
10
0.4 ± 0.09
0.8
Alprazolam
3.9 ± 1.2
5.6
1.9 ± 0.4
19
3.4 ± 0.9
6.8
Zopiclone
6.6 ± 1.1
9.4
5.7 ± 0.5
57
4.7 ± 0.7
9.4
Zolpidem
7.0 ± 1.6
10.0
13.4 ± 2.8
134
6.8 ± 1.0
13.6
Diazepam
10.9 ± 0.5.
15.6
7.4 ± 0.6
74
10.6 ± 0.5
21.2
NOTE: IC50 is the 50% inhibitory concentration. Ratio indicates ratio of IC50 of drug to IC50 of Halcion.
