TABLE B-3 Displacement of [3H]Flumazenil in Rats as Determined by In Vivo Autoradiography

 

Cortex

 

Spinal Cord

 

Cerebellum

 

Drug

IC50 (mg/kg)

Ratio

IC50 (mg/kg)

Ratio

IC50 (mg/kg)

Ratio

Halcion

0.7 ± 0.1

1

0.1 ± 0.8

1

0.5 ± 0.08

1.0

Clonazepam

0.3 ± 0.07

0.04

0.3 ± 0.08

3

0.3 ± 0.07

0.6

Lorazepam

0.8 ± 0.3

1.1

1.0 ± 0.3

10

0.4 ± 0.09

0.8

Alprazolam

3.9 ± 1.2

5.6

1.9 ± 0.4

19

3.4 ± 0.9

6.8

Zopiclone

6.6 ± 1.1

9.4

5.7 ± 0.5

57

4.7 ± 0.7

9.4

Zolpidem

7.0 ± 1.6

10.0

13.4 ± 2.8

134

6.8 ± 1.0

13.6

Diazepam

10.9 ± 0.5.

15.6

7.4 ± 0.6

74

10.6 ± 0.5

21.2

NOTE: IC50 is the 50% inhibitory concentration. Ratio indicates ratio of IC50 of drug to IC50 of Halcion.

SOURCE: Sanger and Benavides (1993).



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