|
Source
|
Type
|
Population
|
Number of Subjects
|
Drug and Dose
|
Duration
|
Outcome/Comment
|
|
Roth et al. (1980)
|
Placebo/BZ
|
Bedtime
|
11
|
Placebo
Flurazepam 30 mg
Halcion 0.5 mg
Lorazepam 4 mg
|
2 nights/week over
4 weeks
|
Lorazepam equivalent to Halcion impairing, immediate and delayed (tested following morning) recall (both amnestic) vs. placebo and flurazepam. Flurazepam impairs vs. placebo to typical dose, but appropriate for the comparison. More rapid return to sleep may be a factor contributing to sleep may be a factor contributing to interference with memory consolidation with Halcion (difference in minutes).
|
|
Spinweber and Johnson (1982)
|
Placebo
|
Male, insomniac
|
10
10
|
Halcion 0.5 mg
Placebo
|
6 treatment nights
2 withdrawal
|
Reaction time, digit symbol, Williams Word Memory and Card Song Sorting Deficits Evident Immediate to 5 h after drug administration. Paired associate task administered prior to Halcion did not show a.m. memory, impairment.
|
|
Roehrs et al. (1983)
|
Placebo/flurazepam secobarbital
|
Male, Bedtime
|
12
|
Halcion 0.25 and 0.5 mg
Placebo
Flurazepam 30 mg
Secobarbital 200 mg
Lorazepam 4 mg
|
6 days of administration for each agent, 1 day of withdrawal
|
Halcion memory impairment was dose-dependent. Acute: lorazepam = Halcion, 25 = flurazepam < Halcion. 0.5 = Secobarbital. Over 6 days no change with Halcion or secobarbital. Effect from flurazepam worsened (accumulation?) to equal that of Halcion at 5 mg. Tolerance to lorazepam appeared to develop.
|
|
Scharf et al. (1988)
|
Three studies
|
Bedtime
Insomniac
Insomniac
|
22
22
30
|
Halcion 0.5 mg/placebo
Halcion 0.5 mg/placebo
Temazepam 30 mg
|
Single dose
|
Halcion, but not temazepam, showed. evidence of anterograde memory impairment.
|
|
Greenblatt et al. (1989)
|
Placebo/active
|
Bedtime
|
16
12
13
11
|
Placebo
Flurazepam 15 mg
Temazepam 15 mg
Halcion 0.25 mg
|
Single dose
|
List learning at 24 h: Halcion < flurazepam = temazepam  placebo. Possible bias against Halcion from a State Department learning perspective.
|
|
Penetar et al. (1989)
|
Placebo
|
Bedtime, Aerial Deployment
|
33
35
|
Halcion 0.5 mg
Placebo
|
Single dose
|
Logical memory WMS impairment at 8 h by Halcion vs. placebo. Stimuli presented while receiving drug.
|
|
Griffiths et al. (1986)
|
Placebo/active
|
Bedtime (within subject)
|
10
|
Zopiclone 7.5 mg
Flurazepam 15 mg
Lormetazepam 1 mg
Halcion 0.25 mg
Placebo
|
Single dose
|
Stroop, memory span, logical reasoning, mood, and saccadic eye movement all were similarly drug sensitive.
|
