TABLE B-8 IOM Summary of Studies Investigating Possible Unique Disinhibiting Effects of Halcion

Source

Type

Population

Number of Subjects

Drug and Dose

Duration

Outcome and Comments

Monti et al. (1994)

Placebo, zolpidem

Insomniac outpatient

8

Zolpidem 10 mg

27 nights

One episode of aggressiveness only for a subject receiving Halcion

8

Halcion 0.5 mg

8

Placebo

Adam and Oswald (1988)

Placebo

Insomnia

40

Halcion 0.5 mg

15 nights of placebo,

25 nights medication,

5 nights placebo

One subject irritable, bragging, sarcastic

40

Lormetazepam 2 mg

40

Placebo



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