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FIGURE 8-1 Mean plasma homocysteine (Hcy) concentrations (and 95% confidence intervals) by deciles of intake of folate. Means are adjusted for age, gender, and other vitamin intakes. Asterisk indicates significantly different from mean in the highest decile (p < 0.01). Reprinted with permission, from Selhub et al. (1993). Copyright 1993 by the American Medical Association.

FIGURE 8-2 Relationship of plasma homocysteine concentrations to plasma folate concentrations in 209 adult males. A indicates lower limit of normal plasma folate as used by the Second National Health and Nutrition Examination Survey (6.8 nmol/L). B indicates lower limit of normal plasma folate as used by the World Health Organization (13.6 nmol/L). Homocysteine concentrations above the dotted line (12 µmol/L) are considered elevated. Reprinted with permission, from Lewis et al. (1992). Copyright 1992 by the New York Academy of Sciences.



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