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Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (1998)
Institute of Medicine (IOM)

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. "10 Pantothenic Acid." Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: The National Academies Press, 1998.

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DRI Dietary Reference Intakes: For Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline

composition were based on microbiological assays for pantothenic acid. A high-performance liquid chromatography method was published relatively recently and has been used for the analysis of pantothenic acid in infant formulas (Romera et al., 1996). However, data on the pantothenic acid content of food regardless of method are very limited. Chicken, beef, potatoes, oat cereals, tomato products, liver, kidney, yeast, egg yolk, broccoli, and whole grains are reported to be major sources of pantothenic acid (Plesofsky-Vig, 1996; Walsh et al., 1981). Royal bee jelly and ovaries of tuna and cod have very high levels of pantothenic acid (Robinson, 1966), but refined grains, fruit products, and meats and fish with added fats or cereal extenders appear to be lower in pantothenic acid content. Freezing and canning of vegetables, fish, meat, and dairy products has been shown to decrease the pantothenic acid content of those foods (Schroeder, 1971). Processing and refining grains resulted in a 37 to 74 percent loss of pantothenic acid (Walsh et al., 1981).

Dietary Intake

The major surveys of nutrient intake used in this report (the U.S. Department of Agriculture Continuing Survey of Food Intakes by Individuals, the Third National Health and Nutrition Examination Survey, and the Boston Nutritional Status Survey) do not estimate the pantothenic acid intake from diet, largely because of the incompleteness of data on the pantothenic acid content of food. Usual daily intakes of about 4 to 7 mg have been reported quite consistently in small groups of adolescents and adults of various ages (Bull and Buss, 1982; Kathman and Kies, 1984; Srinivasan et al., 1981; Tarr et al., 1981). Data from a survey conducted in one province in Canada indicated median daily intakes of pantothenic acid from foods of approximately 5 mg for men and 4 mg for women (Santé Québec, 1995).

Intake from Supplements

Results from the 1986 National Health Interview Survey indicate that 22 percent of U.S. adults took a supplement containing pantothenic acid (Moss et al., 1989).

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369
Front Matter (R1-R24)
Summary (1-16)
1 Introduction to Dietary Reference Intakes (17-26)
2 The B Vitamins and Choline: Overview and Methods (27-40)
3 A Model for the Development of Tolerable Upper Intake Levels (41-57)
4 Thiamin (58-86)
5 Riboflavin (87-122)
6 Niacin (123-149)
7 Vitamin B6 (150-195)
8 Folate (196-305)
9 Vitamin B12 (306-356)
10 Pantothenic Acid (357-373)
11 Biotin (374-389)
12 Choline (390-422)
13 Uses of Dietary Reference Intakes (423-436)
14 A Research Agenda (437-442)
A Origin and Framework of the Development of Dietary Reference Intakes (443-447)
B Acknowledgments (448-450)
C Système International d'Unités (451-452)
D Search Strategies (453-455)
E Methodological Problems Associated with Laboratory Values and Food Composition Data for B Vitamins (456-459)
F Dietary Intake Data from the Boston Nutritional Status Survey, 1981–1984 (460-465)
G Dietary Intake Data from the Continuing Survey of Food Intakes by Individuals (CSFII), 1994–1995 (466-477)
H Dietary Intake Data from the Third National Health and Nutrition Examination Survey (NHANES III), 1988–1994 (478-501)
I Daily Intakes of B Vitamins by Canadian Men and Women, 1990, 1993 (502-506)
J Options for Dealing with Uncertainties in Developing Tolerable Upper Intake Levels (507-511)
K Blood Concentrations of Folate and Vitamin B12 from the Third National Health and Nutrition Examination Survey (NHANES III), 1988–1994 (512-519)
L Methylenetetrahydrofolate Reductase (520-522)
M Evidence from Animal Studies on the Etiology of Neural Tube Defects (523-526)
N Estimation of the Period Covered by Vitamin B12 Stores (527-530)
O Biographical Sketches (531-536)
P Glossary and Abbreviations (537-540)
Index (541-567)