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Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (1998)
Institute of Medicine (IOM)

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. "13 Uses of Dietary Reference Intakes." Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: The National Academies Press, 1998.

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DRI Dietary Reference Intakes: For Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline

range weighing 50 kg (110 lb), 55 kg (121 lb), or 70 kg (154 lb) despite the differences in size and energy expenditure.

Reference weights are provided (Chapter 1, Table 1-2) to allow a calculation, when necessary, of the amount of nutrient per unit of body weight for individuals who are greatly outside the typical range of body size. These weights may also be useful for infants and children, whose average weights change substantially with age. Ordinarily, adjusting values for the nutrients included in this report based on reported energy intake has not been recommended; little justification for this practice could be found in the literature for individuals eating typical diets.

Assessing the Adequacy of Nutrient Intakes of an Individual

Although RDAs have been used to assess the adequacy of an individual’s nutrient intake in the past, this practice has serious limitations if a person’s intake is less than the RDA. An individual’s nutrient requirement is never known with certainty; only the approximate distribution of requirements for the life stage group may be known. If the individual’s intake on average meets or exceeds the RDA, there is good assurance that the intake is adequate for the specified criterion. If an individual’s average intake over time is less than the RDA, it can be inferred only that there is some increased likelihood that the intake is inadequate. The likelihood increases the further the intake falls below the RDA. For a requirement that is normally distributed, when the usual intake is less than 2 standard deviations below the Estimated Average Requirement (EAR), the likelihood that the individual’s requirement would be met would be small (NRC, 1986). A usual intake that is well below the RDA may indicate the need for further assessment of nutritional status by biochemical tests or clinical examination.

USING ADEQUATE INTAKES

As is true for the Recommended Dietary Allowance (RDA), healthy individuals with an average daily intake at or above the Adequate Intake (AI) are assumed to be at low risk of intake inadequate for a defined state of nutrition. This is its most important use. Similarly, if an individual’s average intake over time is less than the AI, it can be inferred only that there is some likelihood that the intake is inadequate. The likelihood increases the further the intake falls below the AI. Just as with the RDA, a usual intake that is well below

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Front Matter (R1-R24)
Summary (1-16)
1 Introduction to Dietary Reference Intakes (17-26)
2 The B Vitamins and Choline: Overview and Methods (27-40)
3 A Model for the Development of Tolerable Upper Intake Levels (41-57)
4 Thiamin (58-86)
5 Riboflavin (87-122)
6 Niacin (123-149)
7 Vitamin B6 (150-195)
8 Folate (196-305)
9 Vitamin B12 (306-356)
10 Pantothenic Acid (357-373)
11 Biotin (374-389)
12 Choline (390-422)
13 Uses of Dietary Reference Intakes (423-436)
14 A Research Agenda (437-442)
A Origin and Framework of the Development of Dietary Reference Intakes (443-447)
B Acknowledgments (448-450)
C Système International d'Unités (451-452)
D Search Strategies (453-455)
E Methodological Problems Associated with Laboratory Values and Food Composition Data for B Vitamins (456-459)
F Dietary Intake Data from the Boston Nutritional Status Survey, 1981–1984 (460-465)
G Dietary Intake Data from the Continuing Survey of Food Intakes by Individuals (CSFII), 1994–1995 (466-477)
H Dietary Intake Data from the Third National Health and Nutrition Examination Survey (NHANES III), 1988–1994 (478-501)
I Daily Intakes of B Vitamins by Canadian Men and Women, 1990, 1993 (502-506)
J Options for Dealing with Uncertainties in Developing Tolerable Upper Intake Levels (507-511)
K Blood Concentrations of Folate and Vitamin B12 from the Third National Health and Nutrition Examination Survey (NHANES III), 1988–1994 (512-519)
L Methylenetetrahydrofolate Reductase (520-522)
M Evidence from Animal Studies on the Etiology of Neural Tube Defects (523-526)
N Estimation of the Period Covered by Vitamin B12 Stores (527-530)
O Biographical Sketches (531-536)
P Glossary and Abbreviations (537-540)
Index (541-567)