Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline

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Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (1998)
Institute of Medicine (IOM)

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. "E Methodological Problems Associated with Laboratory Values and Food Composition Data for B Vitamins." Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: The National Academies Press, 1998.

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DRI Dietary Reference Intakes: For Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline

	Thiamin	Riboflavin	Niacin	B₆
How are problems with methods addressed in the report?	Not necessary	Earlier under-and over-estimations of flavins noted.	Questions for research	Not necessary
^a Gunter EW, Bowman BA, Caudill SP, Twite DB, Adams MJ, Sampson EJ. 1996. Results of an international round robin for serum and whole-blood folate. Clin Chem 42:1689–1694.

TABLE E-2 Methodologic Problems with Obtaining Food Composition Data for B Vitamins

	Thiamin	Riboflavin	Niacin	B₆
Are precise, accurate methods available?^a	Substantial, acceptable quality	Substantial, acceptable quality	Substantial, acceptable quality	Substantial, acceptable quality
Is there good agreement in results using different methods?	Fair when allowance is made for specificity differences
Over time, how have changes in methods affected estimates?	None noted	About the same or slightly lower	None noted	Slightly higher now
^a Ratings for the B vitamins (but not for choline) are taken from Life Sciences Research Office/Federation of American Societies for Experimental Biology. 1995. Third Report on Nutrition Monitoring in the United States. Washington, DC: U.S. Government Printing Office. ^b Quality of data was rated moot if it was considered unlikely that improved data for that food component would make a difference in the assessment of nutrition-related health status and the assignment of nutrition monitoring priority status (LSRO/FASEB, 1995).