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Biomedical Models and Resources: Current Needs and Future Opportunities APPENDIX B BIOGRAPHICAL SKETCHES OF AUTHORING COMMITTEE; WORKSHOP AGENDA; AND WORKSHOP PARTICIPANTS MURIEL T. DAVISSON, PhD, CHAIRWOMAN Dr. Davisson is a senior scientist and director of genetic resources at The Jackson Laboratory in Bar Harbor, Maine. She is an internationally recognized mouse geneticist and is a member of the ILAR Council. STEPHEN W. BARTHOLD, DVM, PhD, Dipl ACVP Dr. Barthold is professor and director of the University of California Center for Comparative Medicine, a research center featuring investigation of diseases common to humans and animals. The center is supported jointly by the schools of medicine and veterinary medicine. Dr. Barthold recently relocated to California after 23 years at Yale University School of Medicine, where he was professor of comparative medicine. His research involves pathogenesis of infectious disease in animal models, and his professional specialty is diseases of laboratory rodents and lagomorphs. BENNETT DYKE, PhD Dr. Dyke is a scientist at the Southwest Foundation for Biomedical Research in San Antonio, Texas. He is a population geneticist and developer of biologic databases. He recently chaired the editorial panel of ILAR Journal that was devoted to computational models in animal research. ROGER HANLON, PhD Dr. Hanlon is senior scientist and director of the Marine Resources Center (MRC) at the Marine Biological Laboratory in Woods Hole, Massachusetts. The MRC houses more than 100 aquatic species that are used in basic biological and biomedical research and teaching nationwide. Dr. Hanlon has extensive experience in mariculture and investigates the behavior and sensory biology of cephalopods and fishes.
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Biomedical Models and Resources: Current Needs and Future Opportunities ROBERT J. RUSSELL, DVM, MS Dr. Russell received his DVM degree from the University of Illinois and his MS from Texas A and M University. He is a diplomate of the American College of Laboratory Animal Medicine. Since 1985, he has been director of laboratory animal medicine for the worldwide operations of the Harlan Group of companies. His particular interests and experience include the development and provision of laboratory animals with known health, phenotypic, and genetic characteristics for use in biomedical and behavioral research. He collaborates extensively with investigators in the United States and Europe to help meet their specific research requirements and project goals. PHILIP A. WOOD, DVM, PhD Dr. Wood is professor and interim chairman of the Department of Comparative Medicine at the University of Alabama at Birmingham. He is an active investigator involved in understanding the molecular genetics of metabolism and elucidating molecular mechanisms of metabolic diseases using animal models, particularly transgenic and gene knockout mouse models. A major interest is the role of aberrant fatty acid metabolism in both rare inherited diseases and more common diseases, such as diabetes mellitus and obesity.
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Biomedical Models and Resources: Current Needs and Future Opportunities Biological Models Workshop National Research Council Washington, DC December 11–12, 1997 AGENDA Thursday, December 11 7:30 a.m. Continental Breakfast served in Green Building, Room GR 104 8:00 a.m. 1. Opening Session Bob Shope A. Welcome, Goals and Overview of the Workshop B. Charge to the NRC Committee C. Review of Survey Muriel Davisson Paul Gilman Muriel Davisson 8:15 a.m. 2. Emerging Research Areas-Future Prospects and Model Needs 8:15 A. Neurobiology and Learning Jack Byrne 8:50 B. Common Diseases and Functional Genomics Jeff Rogers 9:25 C. Aging Anna McCormick 10:00 D. Development and Reproduction Gwen Childs 10:35 a.m. Break 10:50 E. Infectious Disease Bob Shope 11:25 F. Immunology Ethan M. Shevach 12:00 G. Xenotransplantation Glen L. Spaulding 12:30 p.m. Lunch in meeting room 1:30 p.m. H. General Discussion of morning session issues Bob Shope
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Biomedical Models and Resources: Current Needs and Future Opportunities 3. Overriding Issues that Affect All Areas Melinda Novak A. Intellectual property rights Maria Freire B. Behavior Melinda Novak C. Whole Animal Studies 1) Physiologic assessment 2) Morphologic assessment Andrew Greene Charles Montgomery D. Phenotype and Model Databases Alan Hillyard -Participant Peter Tonellato E. Theoretical Biology Modeling Alan Perelson F. Adventitious microorganisms Jim Fox 4. Preparation for Friday morning breakout sessions Melinda Novak A. General discussion of issues raised during the day B. List of topics to be addressed in breakout sessions • Areas discussed Thursday to which models can contribute most • Infrastructure needs, e.g. animal facilities, other? • Technology needs, e.g. imaging • What impedes model development in these species • What facilitates model development in these species • Training needs • Bioinformatics, database, computer management of data needs C. Assignment of participants to breakout sessions 4:15 -Breakout discussion leaders meet with Muriel Davisson and Tom Wolfle 5:00 p.m. Reception Friday, December 12 7:30 a.m. Continental Breakfast served in Green Building, Room GR 110 (note change) 8:00 a.m. 5. Breakout sessions by species areas. Short discussion-- GR 110 Muriel Davisson A. Mammalian Models-- GR 110 Mark Haskins
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Biomedical Models and Resources: Current Needs and Future Opportunities B. Nonmammalian Vertebrate Models (Aquatic and Terrestrial)-- GR 105 1) Aquatic 2) Terrestrial Michael Schmale David Crews C. Invertebrates-- GR 122 Mike Hadfield -Participant Nick Strausfield D. Non-animal models, alternatives-- GR 127 (Computer/mathematical models) Peter Tonellato -Participants Alan Perelson Ralph Dell 12:00 p.m. Lunch in meeting room 1:00 p.m. 6. Reports from breakouts 7. General discussion Mike Hadfield • What is NCRR's role in model development, support, infrastructure • What can NCRR do that is unique, other institutes don't do • Priorities-how to set • Criteria for setting priorities, determining what to find 8. Workshop Summary and Concluding Remarks Mike Hadfield Muriel Davisson
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Biomedical Models and Resources: Current Needs and Future Opportunities Biological Models Workshop National Research Council December 11–12, 1997 Workshop Participants Dr. Jack Byrne, Professor and Chairman, Department of Neurobiology, University of Texas Medical School Dr. Gwen Childs, Professor & Vice-Chair, Department of Anatomy and Neurosciences, University of Texas Medical Branch, Program Director of Cell Biology Graduate Program Dr. David Crews, Professor of Zoology and Psychology, Department of Zoology, University of Texas Dr. James Fox, Professor and Director, Division of Comparative Medicine, Massachusetts Institute of Technology Dr. Maria Freire, Director, Office of Technology Transfer, National Institutes of Health Dr. Andrew Greene, Associate Professor of Physiology, Director of Physiological Genomics, Department of Physiology, Medical College of Wisconsin Dr. Michael Hadfield, Professor of Zoology, Director, Kewalo Marine Laboratory, Pacific Biomedical Research Center, University of Hawaii Dr. Mark Haskins, Professor of Pathology and Medical Genetics, School of Veterinary Medicine, University of Pennsylvania Dr. Alan Hillyard, Chief Technical Officer and Director, Base4 Bioinformatics Dr. Anna McCormick, Chief, Biology Branch, and Genetics Program Director, Biological Aging Program, National Institute on Aging, National Institutes of Health Dr. Charles Montgomery, Director, Center of Comparative Medicine, Baylor College of Medicine Dr. Melinda Novak, Professor and Chair, Department of Psychology, University of Massachusetts Dr. Alan Perelson, Group Leader for Theoretical Biology, Biophysics Group, Los Alamos National Laboratory Dr. Jeffrey Rogers, Associate Scientist, Southwest Foundation for Biomedical Research Dr. Michael Schmale, Associate Professor, Division of Marine Biology and Fisheries, Rosentiel School of Marine and Atmospheric Science, University of Miami Dr. Ethan Shevach, Chief, Cellular Immunology Section, Laboratory of Immunology, National Institute of Allergy & Infectious Diseases, National Institutes of Health Dr. Robert Shope, Professor of Pathology, Department of Pathology, University of Texas Medical Branch Dr. Glen Spaulding, Director of Contract Research and Biotechnology, Director, Division of Laboratory Animal Medicine, Tufts University School of Veterinary Medicine Dr. Nick Strausfeld, Professor of Neurobiology, Professor of Ecology & Evolutionary Biology, ARL Division of Neurobiology, University of Arizona Dr. Peter Tonellato, Associate Professor, Mathematics, Statistics and Computer Science, Marquette University; Director, Informatics Research Center, Medical College of Wisconsin ILAR Staff Ralph Dell, Director, Institute for Laboratory Animal Research, National Research Council Thomas Wolfle, Past Director, Institute for Laboratory Animal Research, National Research Council Kathleen Beil, Project Assistant, Institute for Laboratory Animal Research, National Research Council