issues that are NCRR-specific—unlikely to be supported by other agencies or organizations—and issues that are beyond the scope of NCRR but nonetheless important for the biomedical enterprise. Examples of the former are maintenance and cryopreservation, academic and facilities infrastructure, training, and informatics and miniaturization of instrumentation and databases. Examples of the latter are the contentious issue of indirect costs as detailed in Circular A-21 and intellectual property rights.


    The purpose of this report is to recommend a role for NCRR in developing and supporting biologic models. The committee's recommendations are grouped into the following categories: animal health and welfare, national centers of expertise, animal facilities, training, interdisciplinary research, and scientific advice to NCRR. The committee believes that these categories are the ones most suited to NCRR and are critical to the success of biomedical research.


    The committee's recommendations would be incomplete without criteria by which funding priorities can be set. That is the subject of this chapter. This chapter deals specifically with which models to support and which infrastructure will lead to the most productive research and the best models. The suggested criteria result from a composite of all the data used by the committee, with emphasis on the survey.

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