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Antimicrobial Resistance: Issues and Options (1998)
Institute of Medicine (IOM)

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107
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The following HTML text is provided to enhance online readability. Many aspects of typography translate only awkwardly to HTML. Please use the page image as the authoritative form to ensure accuracy.


Fingerprinting, DNA:

Technique used in molecular biology for genome mapping, to identify specific DNA sequences.

Fire blight:

Destructive, highly infectious disease of pome fruits (i.e., apples, pears, etc.) that is caused by Erwinia amylovora and that produces a scorched or blackened appearance of the leaves and twigs, cankers on the trunk, or discoloration of flowers and fruits

Flora:

Populations of commensal bacteria normally present in the intestine, in body orifices, and on the skin.

Footprinting:

Method for detecting sites of interaction between regulatory or promoter proteins and DNA.

Formulary:

Listing of approved drugs for various medical indications, originally created as a cost-controlling measure but used more recently to guide usage of antibiotics based on information about resistance patterns.

Fungus:

Member of a class of relatively primitive organisms; includes mushrooms, yeasts, rusts, molds, and smuts.


Gene:

Unit of heredity; segment of the DNA molecule that carries directions for the structure of a given protein.

Gene expression:

Activity of a gene measured by the amount of gene product (usually a protein or nucleic acid) made by the cell.

Genera:

Plural of genus.

Genetic recombination:

Process by which separate lengths of DNA from different sources are chemically joined to produce new genetic combinations.

Genome:

Full set of genes in any organism.

Genotype:

Genetic constitution of an individual.

Genus:

Taxonomic category subordinate to tribe and superior to a species.

Glycopeptides:

Compounds made up of amino acids and sugars that may have antibacterial activity; vancomycin and teicoplanin are glycopeptide antibiotics.

Gram-negative bacteria:

Bacteria whose cell wall is composed of a thick layer of peptidologlycan covered by an outer membrane of lipoprotein and lipopolysaccharide. In the Gram-staining process these bacteria are decolorized.

Gram-positive bacteria:

Bacteria whose cell wall is composed of a thick layer of peptidologlycan with attached teichoic acids. In the Gram-staining process, these bacteria retain the stain.


Haemophilus influenzae:

Commensal bacterium commonly found in the upper respiratory tract and capable of causing infections such as otitis media, sinusitis, conjunctivitis, bronchopneumonia, and type b meningitis.

Helicobacter pylori:

Bacterium causing gastritis and peptic ulcer disease in humans.

High throughput:

Rapid, high-volume chemical screening for target compounds.

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