For example, what will the external reviewers assess every 3 years—all NIH research, or several selected research programs or areas? Or, will they look at areas of research emphasis established by the NIH director? These include six broad categories: the biology of brain disorders, new avenues for development of therapeutics, genetic medicine, new approaches to pathogenesis, new preventive strategies against disease, and advanced instrumentation and computers in medicine and research. Another possibility is a combination of the above.

Although NIH is well along the path to developing a response to GPRA, a number of issues have yet to be decided.

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