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Assessment of Exposure-Response Functions for Rocket-Emission Toxicants (1998)

Chapter: Appendix C: American Thoracic Society's List of Adverse Respiratory Health Effects

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Suggested Citation:"Appendix C: American Thoracic Society's List of Adverse Respiratory Health Effects." National Research Council. 1998. Assessment of Exposure-Response Functions for Rocket-Emission Toxicants. Washington, DC: The National Academies Press. doi: 10.17226/6205.
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Appendix C
AMERICAN THORACIC SOCIETY'S LIST OF ADVERSE RESPIRATORY HEALTH EFFECTS

THE American Thoracic Society's Scientific Assembly for Environmental and Occupational Health list of adverse respiratory effects is presented below in order from most to least severe.

  1. Increased mortality. (Increased as used here and subsequently means significantly (p < 0.05) increased above that recorded in some standard, comparable population. In selected situations, p < 0.1 might be appropriate.)

  2. Increased incidence of cancer.

  3. Increased frequency of symptomatic asthmatic attacks.

  4. Increased incidence of lower respiratory tract infections.

  5. Increased exacerbations of disease in persons with chronic cardiopulmonary or other disease that could be reflected in a variety of ways:

    1. Less able to cope with daily activities (e.g. shortness of breath or increased anginal episodes).

    2. Increased hospitalizations, both frequency and duration.

    3. Increased emergency ward or physician visits.

    4. Increased pulmonary medication.

    5. Decreased pulmonary function.

  1. Reduction in forced expiratory volume (FEV), or forced vital capacity (FVC) or other tests of pulmonary function:

    1. Chronic reduction in FEV or FVC associated with clinical symptoms.

Suggested Citation:"Appendix C: American Thoracic Society's List of Adverse Respiratory Health Effects." National Research Council. 1998. Assessment of Exposure-Response Functions for Rocket-Emission Toxicants. Washington, DC: The National Academies Press. doi: 10.17226/6205.
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  1. A significant increase in number of persons with FEV below appear to be less important. It should be emphasized that a small, but statistically significant, reduction in a population mean FEV, or FEV0.75, is probably medically significant, because such a difference may indicate an increase in the number of persons with respiratory impairment in the population. In other words, a small part of the population may manifest a marked change that is medically significant to them, but when averaged with the rest of the population, the change appears to be small.

  2. An increased rate of decline in pulmonary function (FEV1) relative to predicted value in adults with increasing age or failure of children to maintain their predicted FEV1 growth curve. Such data must be standardized for sex, race, height, and other demographic and anthropometric factors.

  1. Increased prevalence of wheezing in the chest apart from colds, or of wheezing most days or nights. (The significance of wheezing with colds needs more study and evaluation.)

  2. Increased prevalence or incidence of chest tightness.

  3. Increased prevalence or incidence of cough/phlegm production requiring medical attention.

  4. Increased incidence of acute upper respiratory tract infections that interfere with normal activity.

  5. Acute upper respiratory tract infections that do not interfere with normal activity.

  6. Eye, nose, and throat irritation that might interfere with normal activity (i.e., driving a car) if severe.

REFERENCES

ATS (American Thoracic Society), Scientific Assembly for Environmental and Occupational Health. 1985. Guidelines as to what constitutes an adverse respiratory health effect, with special reference to epidemiologic studies of air pollution. Am. Rev. Respir. Dis. 131:666-668.

Suggested Citation:"Appendix C: American Thoracic Society's List of Adverse Respiratory Health Effects." National Research Council. 1998. Assessment of Exposure-Response Functions for Rocket-Emission Toxicants. Washington, DC: The National Academies Press. doi: 10.17226/6205.
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Page 103
Suggested Citation:"Appendix C: American Thoracic Society's List of Adverse Respiratory Health Effects." National Research Council. 1998. Assessment of Exposure-Response Functions for Rocket-Emission Toxicants. Washington, DC: The National Academies Press. doi: 10.17226/6205.
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Page 104
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The U.S. Air Force is developing a model to assist commanders in determining when it is safe to launch rocket vehicles. The model estimates the possible number and types of adverse health effects for people who might be exposed to the ground cloud created by rocket exhaust during a normal launch or during an aborted launch that results in a rocket being destroyed near the ground.

Assessment of Exposure-Response Functions for Rocket-Emmission Toxicants evaluates the model and the data used for three rocket emission toxicants: hydrogen chloride, nitrogen dioxide, and nitric acid.

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