Table 1. Numbers of domains detected by SMART in the yeast genome, and in the yeast and human fractions of the Swiss Prot database

 

Number of domains annotated

Yeast genome

SwissProt: S.cerevisiae

SwissProt: Homo sapiens

Domain

Full name or function

SMART

SMART

SPa

Pfamb

SMART

SPa

Pfamb

14–3–3

14–3–3 proteins

2

2

2

2

6

6

6

ADF

Actin depolymerization factor

4

3

2

3

4

2

2

ARF

Arf subfamily of small GTPases

5

4

4

3

12

12

12

ArfGap

GAF for Arf-like GTPases

6

5

0

2

0

ARM

Armadillo repeat

14

14

14

1

40

21

13

B41

Band 4.1 homology

0

0

0

0

9

9

9

BTK

BTK-like zinc finger

0

0

0

4

0

C1

PKC conserved region 1

2

2

2

2

38

32

30

C2

PKC conserved region 2

18

14

11

10

21

19

17

CARD

Caspase recruitment domain

0

0

0

0

9

0

CBS

Cystathionine β-synthase-like domain

17

17

0

23

0

CH

Calponin homology

6

4

4

2

35

26

18

CNH

Citron homology

3

2

0

0

0

cNMP

Cyclic nucleotide monophosphate-binding domain

4

4

2

3

12

12

14

CYCc

Adenylyl/guanylyl cyclase

1

1

1

0

15

15

15

DAGKa

DAG kinase (accessory)

0

0

0

6

0

DAGKc

DAG kinase (catalytic)

2

0

0

6

6

DAX

In Dsh and axin

0

0

0

1

0

DEATH

Regulator of cell death

0

0

0

14

10

DEP

In Dsh. egl-10 and pleckstrin

5

5

0

2

0

DYNc

Dynamin

3

3

3

3

4

4

4

EFh

EF-hand

24

24

17

7

124

124

62

FCH

Fes/CIP4 homology domain

4

4

0

3

0

FHA

Forkhead associated domain

14

9

8

9

1

1

1

FYVE

In Fab1, YOTB, Vac1, and EEA1

6

5

2

1

0

GAF

In cGMP-PDEs, adenylyl cyclases, and E.coli fh1A

0

0

0

4

0

HECTc

Homologous to E6-AP carboxyl terminus: ubiquitin ligases

5

4

3

4

4

HR1

PRK kinase homology region 1

2

2

0

0

0

IPPc

Inositol polyphosphate phosphatase

4

2

2

2

2

2

2

IQ

Calmodulin-binding motif

6

6

3

10

2

KISc

Kinesin, catalytic domain

6

6

6

6

6

6

6

LIM

Zinc finger in Lin-11, Is1–1, Mec-3

9

7

5

3

50

50

30

MYSc

Myosin, catalytic domain

5

5

5

5

6

6

6

OPR

Octicosapeptide repeat

1

1

0

4

0

PAC

Motif, C-terminal to PAS

0

0

0

3

0

PAS

Domain in Per, ARNT, Sim

1

1

0

6

6

PBD

p21 Rho-binding domain

3

3

0

3

2

PDZ

In PSD-95, D1g, ZO-1

0

0

0

31

15

PH

Pleckstrin homology domain

27

19

12

13

36

30

27

PI3K_JI3Kb

PI3K: p85-binding domain

0

0

0

0

2

0

PI3K_rbd

P13K: Ras-binding domain

0

0

0

0

3

0

P13Ka

P13K accessory domain

2

2

0

4

0

P13Kc

Phosphoinositide kinase

8

8

8

7

5

5

5

PLAc

Phospholipase A2, catalytic domain

4

4

4

1

1

PLCXc

Phospholipase C, domain X

1

1

1

1

5

5

5

PLCYc

Phospholipase C, domain Y

1

1

1

1

5

5

5

PLDc

Phospholipase D, conserved motif

2

2

0

2

2

PP2Ac

Protein phosphatases 2A

12

12

12

12

10

10

10

PP2Cc

Protein phosphatases 2C

7

6

5

2

2

2

2

Protein kinases

TyrKc: Tyr-specific

0

0

0

70

69

 

 

S_TKc: Ser/Thr-specific

61

58

58

62

62

STYKc: Ser/Thr/Tyr-specific

56

49

46

104(all)

51

49

184(all)

Protein phosphatases

PTPc: Tyr-specific

3

3

3

3

35

34

35

 

DSPc: Dual-specific

5

5

5

7

7

PTPc_DSPc: Tyr-,/Ser-/Thr-

3

3

2

2

1

PTB

Phosphotyrosine-binding domain

0

0

0

0

4

4

PX

Phox proteins’ domain

14

10

1

3

0

RA

In RalGDS, AF-6 (Ras-associating)

1

1

0

4

0



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