FIG. 1. Selected subset of right end sequences showing extensive similarity (reverse complement) to each of the 16 left ends. Long segments of the left ends of all 16 chromosomes were converted to reverse complement and compared with libraries of 1-kb segments of particular chromosomes, chosen on the basis of previous comparisons. The left column is the number of the chromosome from which the left end probe was extracted. The second column is the number of the chromosome with which it was compared. The top of the figure shows the position in the right end sequence in kilobases. The first example is for chromosome (chr) 1 left end compared with chr 14 and exhibits a just over 3-kb reverse complementary region terminating at the right end of chr 14. The double line shows the length of the matches found by FASTA and the % match is shown below. The next example, left end of chr 2 on right end of chr 8, is a case of Y′ repeat similarity and exhibits minor internal deletions or very poorly matching regions. The next example, chr 3 left end on chr 11, does not involve the Y′ repeat and is mostly made up of single-copy (2 copy) sequences. The next example, chr 4 left end (reverse complement) on chr 10, matches for 18.5 kb and requires two lines for display with the leftward part on the upper line, a very extensive reverse complementary region. This figure displays a subset of reverse complementary regions that does not necessarily include the longest and best-matching regions.

chromosomes. While these terminal regions include repeated sequences, they are not entirely composed of them. They include regions consisting of just the few copies resulting from the terminal relationships reported here. The precision of match often reaches 100% in the best-matching regions as shown in Fig. 1. In many cases the central parts of the overlapping regions have the highest precision, and in almost every case one or another of the end parts of the overlap have



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