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NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competence's and with regard for appropriate balance.

This report has been reviewed by a group other than the authors according to procedures approved by a Report Review Committee consisting of members of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine.

This project was supported by Contract No. N01-OD-4-2139 between the National Academy of Sciences and the National Institutes of Health, Grant No. BIR-9512867 from the National Science Foundation, Grant No. APP 0589 from the Burroughs Welcome Fund, and by the Academy-Industry Program of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the view of the organizations or agencies that provided support for this project.

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